Amoebic keratitis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare corneal infection due to the protozoan <i>Acanthamoeba</i> that generally occurs in contact lens wearers and that is characterized by severe ocular pain, blepharospasm, photophobia, eye tearing, blurred vision and foreign body sensation. It can lead to impaired visual acuity if not treated promptly.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Amoebic keratitis | |
| fr | Kératite amibienne | |
| de | Amöbenkeratitis | |
| es | Queratitis amebiana | |
| it | Cheratite da Acantamoeba | |
| nl | Amoebische keratitis | |
| pt | Queratite por Acanthamoeba | |
| pl | Pełzakowe zapalenie rogówki | |
| cs | Akantamébový zánět rohovky | Akantamébová keratitida |
| uk | Амебний кератит | |
| zh | 棘阿米巴性角膜炎 | |
| tr | Amipli keratit |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B60.1+ | NTBT | inclusion | validated |
| ICD-10 | H19.2* | NTBT | inclusion | validated |
| ICD-11 | 1F50 | NTBT | index | validated |
| MONDO | 0005629 | E | validated | |
| MeSH | D015823 | E | validated | |
| UMLS | C0000880 | E | validated | |
| GARD | 9285 | E | validated | |
| MedDRA | 10069408 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:519278Infective keratitis
rare ophthalmic disorders - ORPHA:163588Rare parasitic disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 1 / 100 000 | Europe | Value and class | Validated | European Medicines Agency[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
15 annotations · validated 2017-05-15| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000481 | Abnormal cornea morphology | |
| HP:0011495 | Abnormal corneal epithelium morphology | |
| HP:0200026 | Ocular pain | |
| HP:0000613 | Photophobia | |
| HP:0007856 | Punctate opacification of the cornea | |
| Frequent (79-30%) | ||
| HP:0004329 | Abnormality of the posterior segment of the globe | |
| HP:0012122 | Anterior uveitis | |
| HP:0000518 | Cataract | |
| HP:0100583 | Corneal perforation | |
| HP:0012155 | Decreased corneal sensation | |
| HP:0001089 | Iris atrophy | |
| HP:0100532 | Scleritis | |
| Occasional (29-5%) | ||
| HP:0000593 | Abnormal anterior chamber morphology | |
| HP:0012040 | Corneal stromal edema | |
| HP:0012804 | Corneal ulceration | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 19660733[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/67043
- This record as JSON: /data/d/67043.json