{"orpha":67043,"name":"Amoebic keratitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare corneal infection due to the protozoan <i>Acanthamoeba</i> that generally occurs in contact lens wearers and that is characterized by severe ocular pain, blepharospasm, photophobia, eye tearing, blurred vision and foreign body sensation. It can lead to impaired visual acuity if not treated promptly.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-67043/","orphanet_url":"https://www.orpha.net/en/disease/detail/67043","names":{"fr":{"name":"Kératite amibienne","definition":"Infection rare de la cornée due au protozoaire <i>Acanthamoeba</i> survenant généralement chez les porteurs de lentilles de contact, qui se caractérise par une douleur oculaire intense, un blépharospasme, une photophobie, un larmoiement, une vision floue et une sensation de corps étranger. Si elle n'est pas traitée rapidement, l'infection peut entraîner une baisse de l'acuité visuelle."},"de":{"name":"Amöbenkeratitis"},"es":{"name":"Queratitis amebiana","definition":"Es una infección corneal poco frecuente causada por el protozoo <i>Acanthamoeba</i> que por lo general ocurre en usuarios de lentes de contacto y que se caracteriza por dolor ocular intenso, blefaroespasmo, fotofobia, lagrimeo ocular, visión borrosa y sensación de cuerpo extraño. Puede producir un deterioro de la agudeza visual si no se trata con prontitud."},"it":{"name":"Cheratite da Acantamoeba"},"nl":{"name":"Amoebische keratitis","definition":"Een zeldzame infectie van cornea door het protozoön <i>Acanthamoeba</i> die doorgaans voorkomt bij dragers van contactlenzen en gekarakteriseerd wordt door ernstige pijn aan het oog, blefarospasme, fotofobie, tranende ogen, troebel zicht, en gevoel van vreemd lichaam. Wanneer het niet tijdig wordt behandeld, kan het leiden tot beperking van de gezichtsscherpte."},"pt":{"name":"Queratite por Acanthamoeba"},"pl":{"name":"Pełzakowe zapalenie rogówki"},"cs":{"name":"Akantamébový zánět rohovky","synonyms":["Akantamébová keratitida"]},"uk":{"name":"Амебний кератит","definition":"A rare corneal infection due to the protozoan <i>Acanthamoeba</i> that generally occurs in contact lens wearers and that is characterized by severe ocular pain, blepharospasm, photophobia, eye tearing, blurred vision and foreign body sensation. It can lead to impaired visual acuity if not treated promptly."},"zh":{"name":"棘阿米巴性角膜炎"},"tr":{"name":"Amipli keratit"}},"xrefs":[{"source":"ICD-10","code":"B60.1+","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-10","code":"H19.2*","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"1F50","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"49744193"},{"source":"MONDO","code":"0005629","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D015823","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0000880","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9285","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10069408","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":519278,"name":"Infective keratitis","classifications":[189]},{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":1.0,"area":"Europe","status":"Validated","source":"European Medicines Agency[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-05-15","source":"19660733[PMID]","terms":[{"hpo":"HP:0000481","label":"Abnormal cornea morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011495","label":"Abnormal corneal epithelium morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0200026","label":"Ocular pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0007856","label":"Punctate opacification of the cornea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0004329","label":"Abnormality of the posterior segment of the globe","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012122","label":"Anterior uveitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000518","label":"Cataract","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100583","label":"Corneal perforation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012155","label":"Decreased corneal sensation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001089","label":"Iris atrophy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100532","label":"Scleritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000593","label":"Abnormal anterior chamber morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012040","label":"Corneal stromal edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012804","label":"Corneal ulceration","frequency":"Occasional (29-5%)","criteria":null}]}}