ORPHA:667662

Breast implant-associated anaplastic large cell lymphoma

Synonyms: Breast implant-associated ALCL · Seroma-associated ALCL

Type: Disease
Group: Disorder
Inheritance: Not applicable
Age of onset: Adult, Elderly
Status: active

A rare T-cell non-Hodgkin lymphoma characterized clinically by tumor developing exclusively after exposure to textured breast implants, and arising typically from the periprosthetic capsule surrounding them. Despite being a hematological malignancy, it behaves as a solid tumor.

Names in Orphadata languages

10 of 12 languages

Lang	Name	Synonyms
en	Breast implant-associated anaplastic large cell lymphoma	Breast implant-associated ALCL · Seroma-associated ALCL
fr	Lymphome anaplasique à grandes cellules lié à un implant mammaire	LACG associé à un implant mammaire · LACG associé à un sérome
de	Brustimplantat-assoziiertes anaplastisches großzelliges Lymphom	BIA-ALCL · Serom-assoziiertes ALCL
es	Linfoma anaplásico de células grandes asociado a implantes mamarios	LACG asociado a implantes mamarios · LACG asociado a seroma
it	Linfoma anaplastico a grandi cellule correlato alle protesi mammarie	ALCL correlato al sieroma · ALCL correlato alle protesi mammarie
nl	Anaplastisch grootcellig lymfoom geassocieerd met borstimplantaat	ALCL geassocieerd met borstimplantaat · ALCL geassocieerd met seroom
pt	Linfoma anaplásico de células grandes associado a implante mamário	ALCL associado a implante mamário · ALCL associado a seroma
pl	Breast implant-associated anaplastic large cell lymphoma	= en
cs	Anaplastický velkobuněčný lymfom spojený s prsními implantáty	= en
uk	Анапластична великоклітинна лімфома, асоційована з грудним імплантатом	Асоційована з грудними імплантатами ALCL · Серома-асоційована ALCL

Definition in:

Cross-references

qualifier = Orphanet mapping relation

Source	Code	Qualifier	ICD relation	Validation
ICD-10	C84.7	NTBT	attributed	validated
ICD-11	2A90.B	NTBT	index	validated
ICD-11	XH05D8	E	specific	validated
MONDO	0850112	E		validated
MONDO	850112	E		validated
UMLS	C4528210	E		validated
MedDRA	10082495	E		validated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

Classification

Preferential parent (Orphanet linearisation):

ORPHA:250908Rare neoplastic disease

Parents in the classifications (1):

ORPHA:171918T-cell non-Hodgkin lymphoma
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders

No children.

Genes

7 direct

Gene	Association	Status	HGNC	Ensembl	OMIM	Locus	Name	Source of validation
JAK1	Disease-causing somatic mutation(s) in	Assessed	HGNC:6190	ENSG00000162434	147795	1p31.3	Janus kinase 1	33660353[PMID]
STAT3	Disease-causing somatic mutation(s) in	Assessed	HGNC:11364	ENSG00000168610	102582	17q21.2	signal transducer and activator of transcription 3	30546832[PMID]
BRCA1	Major susceptibility factor in	Assessed	HGNC:1100	ENSG00000012048	113705	17q21.31	BRCA1 DNA repair associated	40512039[PMID]
BRCA2	Major susceptibility factor in	Assessed	HGNC:1101	ENSG00000139618	600185	13q13.1	BRCA2 DNA repair associated	40512039[PMID]
TP53	Major susceptibility factor in	Assessed	HGNC:11998	ENSG00000141510	191170	17p13.1	tumor protein p53	30546832[PMID]
JAK2	Part of a fusion gene in	Assessed	HGNC:6192	ENSG00000096968	147796	9p24.1	Janus kinase 2	33660353[PMID]
STAT3	Part of a fusion gene in	Assessed	HGNC:11364	ENSG00000168610	102582	17q21.2	signal transducer and activator of transcription 3	33660353[PMID]

Prevalence and incidence

0 records

No prevalence record in this release.

HPO phenotypes

Orphanet has no HPO annotation for this code in this release.

Sources for this card

Orphanet page: orpha.net/en/disease/detail/667662
This record as JSON: /data/d/667662.json