{"orpha":667662,"name":"Breast implant-associated anaplastic large cell lymphoma","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Breast implant-associated ALCL","Seroma-associated ALCL"],"definition":"A rare T-cell non-Hodgkin lymphoma characterized clinically by tumor developing exclusively after exposure to textured breast implants, and arising typically from the periprosthetic capsule surrounding them. Despite being a hematological malignancy, it behaves as a solid tumor.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-667662/","orphanet_url":"https://www.orpha.net/en/disease/detail/667662","names":{"fr":{"name":"Lymphome anaplasique à grandes cellules lié à un implant mammaire","synonyms":["LACG associé à un implant mammaire","LACG associé à un sérome"],"definition":"Lymphome T non hodgkinien rare, caractérisé sur le plan clinique par le développement d'une tumeur après exposition à des implants mammaires texturés, et provenant généralement de la capsule périprothétique qui les entoure. Bien que celui-ci se comporte comme une tumeur solide, il s'agit d'une hémopathie maligne."},"de":{"name":"Brustimplantat-assoziiertes anaplastisches großzelliges Lymphom","synonyms":["BIA-ALCL","Serom-assoziiertes ALCL"],"definition":"Ein seltenes T-Zell-Non-Hodgkin-Lymphom, das klinisch durch einen Tumor gekennzeichnet ist, der sich ausschließlich nach Kontakt mit texturierten Brustimplantaten entwickelt und typischerweise aus der sie umgebenden periprothetischen Kapsel entsteht. Obwohl es sich um ein hämatologisches Malignom handelt, verhält es sich wie ein solider Tumor."},"es":{"name":"Linfoma anaplásico de células grandes asociado a implantes mamarios","synonyms":["LACG asociado a implantes mamarios","LACG asociado a seroma"],"definition":"Es un linfoma no Hodgkin de células T poco frecuente caracterizado clínicamente por un tumor que se desarrolla exclusivamente tras la exposición a implantes mamarios texturizados y que surge típicamente de la cápsula periprotésica que los rodea. A pesar de ser una neoplasia hematológica maligna, se comporta como un tumor sólido."},"it":{"name":"Linfoma anaplastico a grandi cellule correlato alle protesi mammarie","synonyms":["ALCL correlato al sieroma","ALCL correlato alle protesi mammarie"]},"nl":{"name":"Anaplastisch grootcellig lymfoom geassocieerd met borstimplantaat","synonyms":["ALCL geassocieerd met borstimplantaat","ALCL geassocieerd met seroom"],"definition":"Een zeldzaam T-cel non-Hodgkin-lymfoom, klinisch gekenmerkt door een tumor die uitsluitend ontwikkelt na blootstelling aan getextureerde borstimplantaten, en doorgaans ontstaat uit de periprothetische capsule waardoor deze omgeven worden. Hoewel het gaat om een hematologische maligniteit, gedraagt het zich als een solide tumor."},"pt":{"name":"Linfoma anaplásico de células grandes associado a implante mamário","synonyms":["ALCL associado a implante mamário","ALCL associado a seroma"]},"pl":{"name":"Breast implant-associated anaplastic large cell lymphoma","synonyms":["Breast implant-associated ALCL","Seroma-associated ALCL"]},"cs":{"name":"Anaplastický velkobuněčný lymfom spojený s prsními implantáty","synonyms":["Breast implant-associated ALCL","Seroma-associated ALCL"]},"uk":{"name":"Анапластична великоклітинна лімфома, асоційована з грудним імплантатом","synonyms":["Асоційована з грудними імплантатами ALCL","Серома-асоційована ALCL"]}},"xrefs":[{"source":"ICD-10","code":"C84.7","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2A90.B","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1216213663"},{"source":"ICD-11","code":"XH05D8","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1753191438"},{"source":"MONDO","code":"0850112","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"850112","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4528210","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10082495","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":171918,"name":"T-cell non-Hodgkin lymphoma","classifications":[194,202,233]}],"children":[],"genes":[{"symbol":"JAK1","name":"Janus kinase 1","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"33660353[PMID]","hgnc":"6190","ensembl":"ENSG00000162434","omim":"147795","loci":["1p31.3"]},{"symbol":"STAT3","name":"signal transducer and activator of transcription 3","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"30546832[PMID]","hgnc":"11364","ensembl":"ENSG00000168610","omim":"102582","loci":["17q21.2"]},{"symbol":"BRCA1","name":"BRCA1 DNA repair associated","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"40512039[PMID]","hgnc":"1100","ensembl":"ENSG00000012048","omim":"113705","loci":["17q21.31"]},{"symbol":"BRCA2","name":"BRCA2 DNA repair associated","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"40512039[PMID]","hgnc":"1101","ensembl":"ENSG00000139618","omim":"600185","loci":["13q13.1"]},{"symbol":"TP53","name":"tumor protein p53","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"30546832[PMID]","hgnc":"11998","ensembl":"ENSG00000141510","omim":"191170","loci":["17p13.1"]},{"symbol":"JAK2","name":"Janus kinase 2","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"33660353[PMID]","hgnc":"6192","ensembl":"ENSG00000096968","omim":"147796","loci":["9p24.1"]},{"symbol":"STAT3","name":"signal transducer and activator of transcription 3","gene_type":"gene with protein product","association":"Part of a fusion gene in","status":"Assessed","source":"33660353[PMID]","hgnc":"11364","ensembl":"ENSG00000168610","omim":"102582","loci":["17q21.2"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult","Elderly"],"prevalence":[],"phenotypes":null}