PANDAS
Synonyms: Pediatric autoimmune disorders associated with Streptococcus infections · Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Childhood
- Status
- active
PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic Streptococcal infection and applied to a subgroup of children with obsessive-compulsive disorder (OCD) and/or tic disorders.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | PANDAS | Pediatric autoimmune disorders associated with Streptococcus infections · Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections |
| fr | PANDAS | Trouble neuropsychiatrique auto-immun par infection à streptocoques |
| de | PANDAS | Autoimmun-Erkrankung mit assoziierter Streptokokken-Infektion im Kindesalter · Pädiatrische autoimmun-neuropsychiatrische Störung mit Streptokokken-Infektion |
| es | PANDAS | |
| it | PANDAS | Malattie autoimmuni pediatriche dovute a infezioni da streptococco · Malattie autoimmuni pediatriche neuropsichiatriche dovute a infezioni da streptococco |
| nl | PANDAS | Pediatrische auto-immune neuropsychiatrische aandoeningen geassocieerd met streptokokkeninfecties · Pediatrische auto-immuunziekten geassocieerd met streptokokkeninfecties |
| pt | PANDAS | Doenças pediátricas autoimunes associadas a infeções estreptocócicas · Doenças pediátricas autoimunes neuropsiquiátricas associadas a infeções estreptocócicas |
| pl | PANDAS | Dziecięce zaburzenia immunologiczne związane z zakażeniami Streptococcus |
| cs | PANDAS | Pediatrické autoimunitní poruchy asociované se streptokokovými infekcemi · Pediatrické autoimunitní neuropsychiatrické poruchy asociované se streptokokovými infekcemi |
| uk | PANDAS | Дитячі аутоімунні розлади, повязані зі стрептококовими інфекціями · Дитячі аутоімунні нервово-психічні розлади, повязані зі стрептококовими інфекціями |
| zh | 伴链球菌感染性小儿自身免疫性神经精神病 | 小儿自身免疫性神经精神病伴链球菌感染 |
| tr | PANDAS | Streptococcus enfeksiyonları ile ilişkili pediyatrik otoimmün bozukluklar · Streptococcus enfeksiyonları ile ilişkili pediyatrik otoimmün nöropsikiyatrik bozukluklar |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G96.8 | NTBT | attributed | validated |
| ICD-11 | 8E4A.0 | NTBT | index | validated |
| MONDO | 0019020 | E | validated | |
| MeSH | C537163 | E | validated | |
| UMLS | C2931429 | E | validated | |
| GARD | 7312 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:306727Postinfectious autoimmune disease with chorea
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
24 annotations · validated 2018-04-18| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0100033 | Tics | |
| Frequent (79-30%) | ||
| HP:0100852 | Abnormal fear/anxiety-related behavior | |
| HP:0007018 | Attention deficit hyperactivity disorder | |
| HP:0002072 | Chorea | |
| HP:0000716 | Depression | |
| HP:0002376 | Developmental regression | |
| HP:0000712 | Emotional lability | |
| HP:0100710 | Impulsivity | |
| HP:0000737 | Irritability | |
| HP:0008770 | Obsessive-compulsive trait | |
| HP:0010865 | Oppositional defiant disorder | |
| HP:0000751 | Personality changes | |
| HP:0002360 | Sleep abnormality | |
| Occasional (29-5%) | ||
| HP:0000756 | Agoraphobia | |
| HP:0002039 | Anorexia | |
| HP:0002829 | Arthralgia | |
| HP:0025253 | Claustrophobia | |
| HP:0002312 | Clumsiness | |
| HP:0040183 | Encopresis | |
| HP:0000805 | Enuresis | |
| HP:0002183 | Phonophobia | |
| HP:0005366 | Recurrent streptococcus pneumoniae infections | |
| HP:0031468 | Separation insecurity | |
| Excluded (0%) | ||
| HP:0100754 | Mania | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 9464208[PMID]_26196028[PMID]_26196024[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/66624
- This record as JSON: /data/d/66624.json