{"orpha":66624,"name":"PANDAS","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Pediatric autoimmune disorders associated with Streptococcus infections","Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus infections"],"definition":"PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic Streptococcal infection and applied to a subgroup of children with obsessive-compulsive disorder (OCD) and/or tic disorders.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-66624/","orphanet_url":"https://www.orpha.net/en/disease/detail/66624","names":{"fr":{"name":"PANDAS","synonyms":["Trouble neuropsychiatrique auto-immun par infection à streptocoques"],"definition":"Le terme PANDAS (<i>Paediatric Autoimmune Disorders Associated with Streptococcus infections</i>) désigne des affections neuropsychiatriques auto-immunes associées à une infection à streptocoques bêta-hémolytiques du groupe A, survenant chez des enfants atteints de troubles obsessionnels compulsifs (TOC) et/ou de tics."},"de":{"name":"PANDAS","synonyms":["Autoimmun-Erkrankung mit assoziierter Streptokokken-Infektion im Kindesalter","Pädiatrische autoimmun-neuropsychiatrische Störung mit Streptokokken-Infektion"],"definition":"Das Akronym PANDAS steht für <u>P</u>ädiatrische <u>a</u>utoimmun-<u>n</u>europsychiatrische Krankheiten (<u>d</u>isorders) mit Infektion durch Gruppe <u>A</u> (beta-hämolysierende)-<u>S</u>treptokokken. Der Name bezieht sich auf eine Untergruppe von Kindern mit obsessiv/kompulsiver Störung (OCD) und/oder Tic-Störung."},"es":{"name":"PANDAS","definition":"El acrónimo PANDAS (en inglés Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic streptococcal infection) se aplica a un subgrupo de niños con trastorno obsesivo-compulsivo (TOC) y/o tics."},"it":{"name":"PANDAS","synonyms":["Malattie autoimmuni pediatriche dovute a infezioni da streptococco","Malattie autoimmuni pediatriche neuropsichiatriche dovute a infezioni da streptococco"]},"nl":{"name":"PANDAS","synonyms":["Pediatrische auto-immune neuropsychiatrische aandoeningen geassocieerd met streptokokkeninfecties","Pediatrische auto-immuunziekten geassocieerd met streptokokkeninfecties"],"definition":"PANDAS is een acroniem voor pediatrische auto-immune neuropsychiatrische aandoeningen geassocieerd met infectie door groep A bèta-hemolytische streptokokken, die optreden bij een subgroep van kinderen met obsessief-compulsieve stoornis (OCD) en/of ticstoornissen."},"pt":{"name":"PANDAS","synonyms":["Doenças pediátricas autoimunes associadas a infeções estreptocócicas","Doenças pediátricas autoimunes neuropsiquiátricas associadas a infeções estreptocócicas"]},"pl":{"name":"PANDAS","synonyms":["Dziecięce zaburzenia immunologiczne związane z zakażeniami Streptococcus"]},"cs":{"name":"PANDAS","synonyms":["Pediatrické autoimunitní poruchy asociované se streptokokovými infekcemi","Pediatrické autoimunitní neuropsychiatrické poruchy asociované se streptokokovými infekcemi"]},"uk":{"name":"PANDAS","synonyms":["Дитячі аутоімунні розлади, повязані зі стрептококовими інфекціями","Дитячі аутоімунні нервово-психічні розлади, повязані зі стрептококовими інфекціями"],"definition":"PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with a group A beta-hemolytic Streptococcal infection and applied to a subgroup of children with obsessive-compulsive disorder (OCD) and/or tic disorders."},"zh":{"name":"伴链球菌感染性小儿自身免疫性神经精神病","synonyms":["小儿自身免疫性神经精神病伴链球菌感染"]},"tr":{"name":"PANDAS","synonyms":["Streptococcus enfeksiyonları ile ilişkili pediyatrik otoimmün bozukluklar","Streptococcus enfeksiyonları ile ilişkili pediyatrik otoimmün nöropsikiyatrik bozukluklar"]}},"xrefs":[{"source":"ICD-10","code":"G96.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8E4A.0","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1557930774"},{"source":"MONDO","code":"0019020","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C537163","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2931429","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7312","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":306727,"name":"Postinfectious autoimmune disease with chorea","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Childhood"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2018-04-18","source":"9464208[PMID]_26196028[PMID]_26196024[PMID]","terms":[{"hpo":"HP:0100033","label":"Tics","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100852","label":"Abnormal fear/anxiety-related behavior","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007018","label":"Attention deficit hyperactivity disorder","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002072","label":"Chorea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002376","label":"Developmental regression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000712","label":"Emotional lability","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100710","label":"Impulsivity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008770","label":"Obsessive-compulsive trait","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010865","label":"Oppositional defiant disorder","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000751","label":"Personality changes","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002360","label":"Sleep abnormality","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000756","label":"Agoraphobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025253","label":"Claustrophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002312","label":"Clumsiness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040183","label":"Encopresis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000805","label":"Enuresis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002183","label":"Phonophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005366","label":"Recurrent streptococcus pneumoniae infections","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031468","label":"Separation insecurity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100754","label":"Mania","frequency":"Excluded (0%)","criteria":null}]}}