ORPHA:66529
Tako-Tsubo cardiomyopathy
Synonyms: Ampulla cardiomyopathy · Apical ballooning syndrome · Ballooning cardiomyopathy · Broken heart syndrome · Stress cardiomyopathy · Tako-Tsubo syndrome · Takotsubo cardiomyopathy · Takotsubo syndrome · Transient left ventricular apical ballooning syndrome
- Type
- Disease
- Group
- Disorder
- Inheritance
- Unknown
- Age of onset
- All ages
- Status
- active
A rare cardiac disease characterized by acute occurrence of heart failure after an emotional or physical trigger; recovery of the wall motion abnormalities are observed within months. Symptoms are similar to acute coronary syndrome (ACS).
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Tako-Tsubo cardiomyopathy | Ampulla cardiomyopathy · Apical ballooning syndrome · Ballooning cardiomyopathy · Broken heart syndrome · Stress cardiomyopathy · Tako-Tsubo syndrome · Takotsubo cardiomyopathy · Takotsubo syndrome · Transient left ventricular apical ballooning syndrome |
| fr | Cardiomyopathie Tako-Tsubo | Syndrome de Takotsubo · Syndrome de ballonisation apicale · Syndrome de l'apex ventriculaire en ballon · Syndrome du coeur brisé · Cardiomyopathie de stress · Syndrome de Tako-Tsubo |
| de | Tako-Tsubo-Kardiomyopathie | Apical-ballooning-Syndrom · Ballonartige Kardiomyopathie · Kardiomyopathie Typ Takotsubo · Stress-Kardiomyopathie · Syndrom der transienten linksventrikulären apikalen Ballonierung · Syndrom des gebrochenen Herzens · Takotsubo-Syndrom |
| es | Miocardiopatía de tako-tsubo | Miocardiopatía de takotsubo · Síndrome de tako-tsubo |
| it | Cardiomiopatia di Tako-Tsubo | Cardiomiopatia ad ampolla · Cardiomiopatia da rigonfiamento · Cardiomiopatia da stress · Cardiomiopatia di Takotsubo · Sindrome da rigonfiamento apicale · Sindrome del cuore spezzato · Sindrome del rigonfiamento apicale transitorio del ventricolo sinistro · Sindrome di Tako-Tsubo · Sindrome di Takotsubo |
| nl | Tako-Tsubo-cardiomyopathie | Ampul-cardiomyopathie · Apicale bolling-syndroom · Ballooning-cardiomyopathie · Cardiomyopathie door stress · Gebroken hart syndroom · Syndroom van Tako-Tsubo · Syndroom van Takotsubo · Takotsubo-cardiomyopathie · Voorbijgaande linkerventriculaire apicale bolling-syndroom |
| pt | Cardiomiopatia Taku-Tsubo | Cardiomiopatia de stress · Cardiomiopatia em balão · Miocardiopatia Takotsubo · Síndrome Tako-Tsubo · Síndrome Takotsubo · Síndrome de balonamento ventricular esquerdo apical transitório |
| pl | Kardiomiopatia tako-tsubo | Kardiomiopatia bańowata · Kardiomiopatia indukowana stresem · Kardiomiopatia Takotsubo · Przejściowy zespół balotowania koniuszka lewej komory · Zespół balotowania koniuszka · Zespół Takotsubo · Zespół Tako-tsubo |
| cs | Tako-Tsubo kardiomyopatie | Ampulová kardiomyopatie · Apikální balónový syndrom · Balonková kardiomyopatie · Stresová kardiomyopatie · Tako-tsubo syndrom · Takotsubo kardiomyopatie · Takotsubo syndrom · Syndrom zlomeného srdce · Přechodný apikální balonový syndrom levé komory · Neurogenní omráčení myokardu |
| uk | Кардіоміопатія Тако-Цубо | Ампульна кардіоміопатія · Синдром апікального балотування · Балонна кардіоміопатія · Синдром розбитого серця · Стресова кардіоміопатія · Кардіоміопатія Такоцубо · Синдром Такоцубо · Синдром Тако-Цубо · Транзиторний синдром верхівкового балотування лівого шлуночка |
| zh | 应激性心肌病 | 短暂性左心室心尖部气球样变综合征 |
| tr | Tako-Tsubo kardiyomiyopatisi | Takotsubo sendromu · Tako-Tsubo sendromu · Kırık kalp sendromu · Stres kardiyomiyopati · Ampulla kardiyomiyopatisi · Takotsubo kardiyomiyopatisi · Balon kardiyomiyopati · Apikal balon sendromu · Geçici sol ventriküler apikal balon sendromu |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | I42.8 | NTBT | attributed | validated |
| ICD-11 | BC43.5 | E | specific | validated |
| MONDO | 0019018 | E | validated | |
| MeSH | D054549 | E | validated | |
| UMLS | C1739395 | E | validated | |
| GARD | 9400 | E | validated | |
| MedDRA | 10066286 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:217678Unclassified cardiomyopathy
rare cardiac diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET_[EXPERT] |
| Annual incidence | 1-9 / 100 000 | 2.98 / 100 000 | France | Value and class | Validated | 23623669[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
6
HPO phenotypes
37 annotations · validated 2024-07-10| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012663 | Mildly reduced ejection fraction | |
| Frequent (79-30%) | ||
| HP:0100749 | Chest pain | |
| HP:0410174 | Increased circulating troponin T concentration | |
| HP:0031483 | Reduced contraction of the left ventricular apex | |
| HP:0012251 | ST segment elevation | |
| HP:0010872 | T-wave inversion | |
| Occasional (29-5%) | ||
| HP:0031138 | Abnormal B-type natriuretic peptide level | |
| HP:0001681 | Angina pectoris | |
| HP:0025077 | Decreased QRS voltage | |
| HP:0006698 | Dilatation of the ventricular cavity | |
| HP:0002094 | Dyspnea | |
| HP:0000822 | Hypertension | |
| HP:0002615 | Hypotension | |
| HP:6001073 | Left ventricular apical dyskinesis | |
| HP:0009805 | Low-output congestive heart failure | |
| HP:0008180 | Mildly elevated creatine kinase | |
| HP:0001513 | Obesity | |
| HP:0001962 | Palpitations | |
| HP:0001657 | Prolonged QT interval | |
| HP:0005184 | Prolonged QTc interval | |
| HP:0012250 | ST segment depression | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0011675 | Arrhythmia | |
| HP:0005110 | Atrial fibrillation | |
| HP:0001662 | Bradycardia | |
| HP:0030149 | Cardiogenic shock | |
| HP:0001653 | Mitral regurgitation | |
| HP:0100598 | Pulmonary edema | |
| HP:0001250 | Seizure | |
| HP:0001279 | Syncope | |
| HP:0001727 | Thromboembolic stroke | |
| HP:0004308 | Ventricular arrhythmia | |
| HP:0001663 | Ventricular fibrillation | |
| Excluded (0%) | ||
| HP:0006704 | Abnormal coronary artery morphology | |
| HP:0005145 | Coronary artery stenosis | |
| HP:0001677 | Coronaryartery atherosclerosis | |
| HP:0012819 | Myocarditis | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 28613549[PMID]_31262719[PMID]_28648424[PMID]_28041712[PMID]_27546831[PMID]
7
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/66529
- This record as JSON: /data/d/66529.json