{"orpha":66529,"name":"Tako-Tsubo cardiomyopathy","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Ampulla cardiomyopathy","Apical ballooning syndrome","Ballooning cardiomyopathy","Broken heart syndrome","Stress cardiomyopathy","Tako-Tsubo syndrome","Takotsubo cardiomyopathy","Takotsubo syndrome","Transient left ventricular apical ballooning syndrome"],"definition":"A rare cardiac disease characterized by acute occurrence of heart failure after an emotional or physical trigger; recovery of the wall motion abnormalities are observed within months. Symptoms are similar to acute coronary syndrome (ACS).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-66529/","orphanet_url":"https://www.orpha.net/en/disease/detail/66529","names":{"fr":{"name":"Cardiomyopathie Tako-Tsubo","synonyms":["Syndrome de Takotsubo","Syndrome de ballonisation apicale","Syndrome de l'apex ventriculaire en ballon","Syndrome du coeur brisé","Cardiomyopathie de stress","Syndrome de Tako-Tsubo"],"definition":"Maladie cardiaque rare caractérisée par l'apparition d'une insuffisance cardiaque aiguë à la suite d'un choc émotionnel ou physique, le rétablissement à la suite des troubles cinétiques étant observé à l'issue de quelques mois. Les symptômes sont similaires à ceux du syndrome coronaire aigu (SCA)."},"de":{"name":"Tako-Tsubo-Kardiomyopathie","synonyms":["Apical-ballooning-Syndrom","Ballonartige Kardiomyopathie","Kardiomyopathie Typ Takotsubo","Stress-Kardiomyopathie","Syndrom der transienten linksventrikulären apikalen Ballonierung","Syndrom des gebrochenen Herzens","Takotsubo-Syndrom"],"definition":"Eine seltene Herzerkrankung, bei der es nach einem emotionalen oder physischen Auslöser zu einer akuten Herzinsuffizienz kommt, wobei sich die Anomalien in den Bewegungen der Herzwand jedoch innerhalb von Monaten erholen. Die Symptome sind ähnlich wie beim akuten Koronarsyndrom (ACS)."},"es":{"name":"Miocardiopatía de tako-tsubo","synonyms":["Miocardiopatía de takotsubo","Síndrome de tako-tsubo"],"definition":"Es una enfermedad cardíaca poco frecuente caracterizada por la aparición de insuficiencia cardíaca aguda después de un desencadenante emocional o físico, en la que la recuperación de las anomalías del movimiento de la pared se observa en un plazo de meses. Los síntomas son similares a los del síndrome coronario agudo (SCA)."},"it":{"name":"Cardiomiopatia di Tako-Tsubo","synonyms":["Cardiomiopatia ad ampolla","Cardiomiopatia da rigonfiamento","Cardiomiopatia da stress","Cardiomiopatia di Takotsubo","Sindrome da rigonfiamento apicale","Sindrome del cuore spezzato","Sindrome del rigonfiamento apicale transitorio del ventricolo sinistro","Sindrome di Tako-Tsubo","Sindrome di Takotsubo"],"definition":"Si tratta di una cardiopatia rara, caratterizzata da insufficienza cardiaca acuta scatenata da uno stress emotivo o fisico. Le anomalie del movimento della parete cardiaca si risolvono nel giro di alcuni mesi. I sintomi ricordano quelli della sindrome coronarica acuta (SCA)."},"nl":{"name":"Tako-Tsubo-cardiomyopathie","synonyms":["Ampul-cardiomyopathie","Apicale bolling-syndroom","Ballooning-cardiomyopathie","Cardiomyopathie door stress","Gebroken hart syndroom","Syndroom van Tako-Tsubo","Syndroom van Takotsubo","Takotsubo-cardiomyopathie","Voorbijgaande linkerventriculaire apicale bolling-syndroom"],"definition":"Een zeldzame hartziekte, gekenmerkt door acuut optreden van hartfalen na een emotionele of fysieke uitlokkende factor; binnen enkele maanden wordt herstel van de afwijkingen in de bewegingen van de hartwand waargenomen. Symptomen zijn gelijkaardig aan die van acuut coronair syndroom (ACS)."},"pt":{"name":"Cardiomiopatia Taku-Tsubo","synonyms":["Cardiomiopatia de stress","Cardiomiopatia em balão","Miocardiopatia Takotsubo","Síndrome Tako-Tsubo","Síndrome Takotsubo","Síndrome de balonamento ventricular esquerdo apical transitório"],"definition":"Doença cardíaca rara caracterizada pela ocorrência de insuficiência cardíaca aguda após um factor desencadeante emocional ou físico; verifica-se a recuperação das anomalias do movimento da parede em poucos meses. Os sintomas são semelhantes aos da síndrome coronária aguda (SCA)."},"pl":{"name":"Kardiomiopatia tako-tsubo","synonyms":["Kardiomiopatia bańowata","Kardiomiopatia indukowana stresem","Kardiomiopatia Takotsubo","Przejściowy zespół balotowania koniuszka lewej komory","Zespół balotowania koniuszka","Zespół Takotsubo","Zespół Tako-tsubo"],"definition":"Rzadka choroba serca charakteryzująca się nagłym wystąpieniem niewydolności serca po zadziałaniu czynnika emocjonalnego lub fizycznego; do normalizacji ruchomości ścian serca dochodzi w ciągu kilku miesięcy. Objawy są podobne do obserwowanych w ostrym zespole wieńcowym."},"cs":{"name":"Tako-Tsubo kardiomyopatie","synonyms":["Ampulová kardiomyopatie","Apikální balónový syndrom","Balonková kardiomyopatie","Stresová kardiomyopatie","Tako-tsubo syndrom","Takotsubo kardiomyopatie","Takotsubo syndrom","Syndrom zlomeného srdce","Přechodný apikální balonový syndrom levé komory","Neurogenní omráčení myokardu"]},"uk":{"name":"Кардіоміопатія Тако-Цубо","synonyms":["Ампульна кардіоміопатія","Синдром апікального балотування","Балонна кардіоміопатія","Синдром розбитого серця","Стресова кардіоміопатія","Кардіоміопатія Такоцубо","Синдром Такоцубо","Синдром Тако-Цубо","Транзиторний синдром верхівкового балотування лівого шлуночка"],"definition":"A rare cardiac disease characterized by acute occurrence of heart failure after an emotional or physical trigger; recovery of the wall motion abnormalities are observed within months. Symptoms are similar to acute coronary syndrome (ACS)."},"zh":{"name":"应激性心肌病","synonyms":["短暂性左心室心尖部气球样变综合征"]},"tr":{"name":"Tako-Tsubo kardiyomiyopatisi","synonyms":["Takotsubo sendromu","Tako-Tsubo sendromu","Kırık kalp sendromu","Stres kardiyomiyopati","Ampulla kardiyomiyopatisi","Takotsubo kardiyomiyopatisi","Balon kardiyomiyopati","Apikal balon sendromu","Geçici sol ventriküler apikal balon sendromu"]}},"xrefs":[{"source":"ICD-10","code":"I42.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"BC43.5","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"478139552"},{"source":"MONDO","code":"0019018","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D054549","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1739395","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9400","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10066286","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97929,"name":"Rare cardiac disease"},"parents":[{"orpha":217678,"name":"Unclassified cardiomyopathy","classifications":[146]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_[EXPERT]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.98,"area":"France","status":"Validated","source":"23623669[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-07-10","source":"28613549[PMID]_31262719[PMID]_28648424[PMID]_28041712[PMID]_27546831[PMID]","terms":[{"hpo":"HP:0012663","label":"Mildly reduced ejection fraction","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0410174","label":"Increased circulating troponin T concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031483","label":"Reduced contraction of the left ventricular apex","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012251","label":"ST segment elevation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010872","label":"T-wave inversion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031138","label":"Abnormal B-type natriuretic peptide level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001681","label":"Angina pectoris","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025077","label":"Decreased QRS voltage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006698","label":"Dilatation of the ventricular cavity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:6001073","label":"Left ventricular apical dyskinesis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009805","label":"Low-output congestive heart failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008180","label":"Mildly elevated creatine kinase","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001513","label":"Obesity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001962","label":"Palpitations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001657","label":"Prolonged QT interval","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005184","label":"Prolonged QTc interval","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012250","label":"ST segment depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005110","label":"Atrial fibrillation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030149","label":"Cardiogenic shock","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001653","label":"Mitral regurgitation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100598","label":"Pulmonary edema","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001279","label":"Syncope","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001727","label":"Thromboembolic stroke","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004308","label":"Ventricular arrhythmia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001663","label":"Ventricular fibrillation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0006704","label":"Abnormal coronary artery morphology","frequency":"Excluded (0%)","criteria":null},{"hpo":"HP:0005145","label":"Coronary artery stenosis","frequency":"Excluded (0%)","criteria":null},{"hpo":"HP:0001677","label":"Coronaryartery atherosclerosis","frequency":"Excluded (0%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Excluded (0%)","criteria":null}]}}