Ovarian hyperstimulation syndrome
Synonyms: OHSS
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Adult
- Status
- active
A rare non-malformative gynecological disease affecting pre-menopausal women usually following treatment with ovarian stimulating hormones, characterized by ovarian enlargement and, to varying degrees, shift of serum from the intravascular space to the third space, mainly into the peritoneal, pleural, and to a lesser extent to the pericardial cavities. Presenting symptoms include abdomen distention, pain, nausea, and vomiting. Severity ranges from mild to life-threatening and is complicated by increased risk of thrombosis, acute hepato-renal failure, acute respiratory distress syndrome, and ovarian torsion and rupture.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Ovarian hyperstimulation syndrome | OHSS |
| fr | Syndrome d'hyperstimulation ovarienne | |
| de | Ovarielles Überstimulationssyndrom | = en |
| es | Síndrome de hiperestimulación ovárica | SHO |
| it | Sindrome da iperstimolazione ovarica | = en |
| nl | Ovarieel hyperstimulatiesyndroom | OHSS · Ovariumhyperstimulatiesyndroom |
| pt | Síndrome hiperestimulação ovárica | SHO |
| pl | Zespół hiperstymulacji jajników | = en |
| cs | Ovariální hyperstimulační syndrom | = en |
| uk | Синдром гіперстимуляції яєчників | = en |
| zh | 卵巢过度刺激综合征 | = en |
| tr | Yumurtalık hiperstimülasyon sendromu | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 608115 | E | validated | |
| ICD-10 | N98.1 | E | specific | validated |
| ICD-11 | GA32.0 | E | specific | validated |
| MONDO | 0011972 | E | validated | |
| MeSH | D016471 | E | validated | |
| UMLS | C0085083 | E | validated | |
| MedDRA | 10033266 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:183731Rare genetic gynecological and obstetrical diseases
rare genetic diseases - ORPHA:180303Rare non-malformative uterine adnexal disease
rare gynecological and obstetric diseases
No children.
Genes
1 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| FSHR | Major susceptibility factor in | Assessed | HGNC:3969 | ENSG00000170820 | 136435 | 2p16.3 | follicle stimulating hormone receptor | 19573286[PMID]_18248882[PMID] |
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
17 annotations · validated 2016-01-20| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0003270 | Abdominal distention | |
| HP:0002027 | Abdominal pain | |
| HP:0001541 | Ascites | |
| HP:0030005 | Capillary leak | |
| HP:0008675 | Enlarged polycystic ovaries | |
| HP:0001007 | Hirsutism | |
| HP:0000837 | Increased circulating gonadotropin level | |
| HP:0030088 | Increased serum testosterone level | |
| HP:0002018 | Nausea | |
| HP:0002017 | Nausea and vomiting | |
| Frequent (79-30%) | ||
| HP:0012886 | Hemorrhagic ovarian cyst | |
| HP:0000138 | Ovarian cyst | |
| HP:0002202 | Pleural effusion | |
| Occasional (29-5%) | ||
| HP:0007430 | Generalized edema | |
| HP:0011106 | Hypovolemia | |
| HP:0012398 | Peripheral edema | |
| HP:0100598 | Pulmonary edema | |
Run the differential on the 10 obligate / very frequent terms
Annotation source: 12930928[PMID]_16679690[PMID]_17721928[PMID]_12930927[PMID]_12930924[PMID]_12498425[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/64739
- This record as JSON: /data/d/64739.json