{"orpha":64739,"name":"Ovarian hyperstimulation syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["OHSS"],"definition":"A rare non-malformative gynecological disease affecting pre-menopausal women usually following treatment with ovarian stimulating hormones, characterized by ovarian enlargement and, to varying degrees, shift of serum from the intravascular space to the third space, mainly into the peritoneal, pleural, and to a lesser extent to the pericardial cavities. Presenting symptoms include abdomen distention, pain, nausea, and vomiting. Severity ranges from mild to life-threatening and is complicated by increased risk of thrombosis, acute hepato-renal failure, acute respiratory distress syndrome, and ovarian torsion and rupture.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-64739/","orphanet_url":"https://www.orpha.net/en/disease/detail/64739","names":{"fr":{"name":"Syndrome d'hyperstimulation ovarienne","definition":"Maladie gynécologique rare autre que malformative affectant la femme préménopausée généralement après traitement hormonal de stimulation ovarienne, caractérisée par une augmentation du volume des ovaires et, à des degrés divers, par une fuite du sérum du secteur vasculaire vers le secteur interstitiel, principalement dans le péritoine et la plèvre et dans une moindre mesure les cavités péricardiques. Les symptômes initiaux sont une distension abdominale, des douleurs, des nausées et des vomissements. Le degré de sévérité varie de léger à engageant le pronostic vital et augmente en cas de risque accru de thrombose, d'insuffisance hépato-rénale aiguë, de syndrome de détresse respiratoire aiguë et de torsion ovarienne ou de rupture de kystes ovariens."},"de":{"name":"Ovarielles Überstimulationssyndrom","synonyms":["OHSS"],"definition":"Eine seltene gynäkologische Erkrankung, die prämenopausale Frauen betrifft und in der Regel nach einer Behandlung mit ovarialstimulierenden Hormonen auftritt. Sie ist gekennzeichnet durch eine Vergrößerung der Eierstöcke und, in unterschiedlichem Ausmaß, durch eine Verlagerung des Serums aus dem intravaskulären Raum in den dritten Raum, hauptsächlich in die Peritoneal-, Pleura- und in geringerem Ausmaß in die Perikardhöhle. Zu den ersten Symptomen gehören ein geblähter Bauch, Schmerzen, Übelkeit und Erbrechen. Der Schweregrad reicht von leicht bis lebensbedrohlich und wird durch ein erhöhtes Thromboserisiko, akutes Leber- und Nierenversagen, akutes Atemnotsyndrom sowie Ovarialtorsion und -ruptur kompliziert."},"es":{"name":"Síndrome de hiperestimulación ovárica","synonyms":["SHO"],"definition":"Es una enfermedad ginecológica no malformativa poco frecuente que afecta a mujeres premenopáusicas que siguen, por lo general, un tratamiento hormonal de estimulación ovárica, caracterizada por un agrandamiento ovárico y, en grado variable, el desplazamiento del suero desde el espacio intravascular al tercer espacio, principalmente al peritoneo, la pleura y, en menor medida, a la cavidad pericárdica. Los síntomas de presentación incluyen distensión abdominal, dolor, náuseas y vómitos. La gravedad de la enfermedad varía de leve a potencialmente mortal, complicándose por el aumento del riesgo de trombosis, insuficiencia hepatorrenal aguda, síndrome de distrés respiratorio agudo y torsión y rotura ováricas."},"it":{"name":"Sindrome da iperstimolazione ovarica","synonyms":["OHSS"],"definition":"Si tratta di una malattia ginecologica rara non malformativa, che colpisce le donne in premenopausa, di solito a seguito di un trattamento con ormoni per la stimolazione ovarica. È caratterizzata da ingrossamento delle ovaie e da una fuoriuscita di entità variabile del siero dallo spazio intravascolare al terzo spazio, per lo più nella cavità peritoneale e pleurica e, in minor misura, nella cavità pericardica. I sintomi d'esordio comprendono la distensione addominale, il dolore, la nausea e il vomito. La malattia può essere sfumata fino a potenzialmente letale, e può associarsi a complicanze quali il rischio di trombosi, l'insufficienza epato-renale acuta, la sindrome da distress respiratorio acuto, la torsione e la rottura ovarica."},"nl":{"name":"Ovarieel hyperstimulatiesyndroom","synonyms":["OHSS","Ovariumhyperstimulatiesyndroom"],"definition":"Een zeldzame niet-malformatieve gynaecologische aandoening die premenopauzale vrouwen treft, meestal na behandeling met ovariumstimulerende hormonen, gekarakteriseerd door vergroting van ovarium en variabele gradaties van verplaatsing van serum van de intravasculaire ruimte naar de derde ruimte, voornamelijk naar peritoneale, pleurale, en in mindere mate pericardiale holtes. Presenterende symptomen zijn onder meer abdominale distensie, pijn, misselijkheid, en braken. De ernst varieert van mild tot levensbedreigend, en wordt gecompliceerd door verhoogd risico op trombose, acuut hepatorenaal falen, acute ademnoodsyndroom, en torsie en ruptuur van ovarium."},"pt":{"name":"Síndrome hiperestimulação ovárica","synonyms":["SHO"]},"pl":{"name":"Zespół hiperstymulacji jajników","synonyms":["OHSS"]},"cs":{"name":"Ovariální hyperstimulační syndrom","synonyms":["OHSS"]},"uk":{"name":"Синдром гіперстимуляції яєчників","synonyms":["OHSS"],"definition":"A rare non-malformative gynecological disease affecting pre-menopausal women usually following treatment with ovarian stimulating hormones, characterized by ovarian enlargement and, to varying degrees, shift of serum from the intravascular space to the third space, mainly into the peritoneal, pleural, and to a lesser extent to the pericardial cavities. Presenting symptoms include abdomen distention, pain, nausea, and vomiting. Severity ranges from mild to life-threatening and is complicated by increased risk of thrombosis, acute hepato-renal failure, acute respiratory distress syndrome, and ovarian torsion and rupture."},"zh":{"name":"卵巢过度刺激综合征","synonyms":["OHSS"]},"tr":{"name":"Yumurtalık hiperstimülasyon sendromu","synonyms":["OHSS"]}},"xrefs":[{"source":"OMIM","code":"608115","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"N98.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"GA32.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1216664013"},{"source":"MONDO","code":"0011972","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D016471","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0085083","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10033266","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":96344,"name":"Rare gynecologic or obstetric disease"},"parents":[{"orpha":183731,"name":"Rare genetic gynecological and obstetrical diseases","classifications":[156]},{"orpha":180303,"name":"Rare non-malformative uterine adnexal disease","classifications":[205]}],"children":[],"genes":[{"symbol":"FSHR","name":"follicle stimulating hormone receptor","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"19573286[PMID]_18248882[PMID]","hgnc":"3969","ensembl":"ENSG00000170820","omim":"136435","loci":["2p16.3"]}],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-01-20","source":"12930928[PMID]_16679690[PMID]_17721928[PMID]_12930927[PMID]_12930924[PMID]_12498425[PMID]","terms":[{"hpo":"HP:0003270","label":"Abdominal distention","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001541","label":"Ascites","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0030005","label":"Capillary leak","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0008675","label":"Enlarged polycystic ovaries","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001007","label":"Hirsutism","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000837","label":"Increased circulating gonadotropin level","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0030088","label":"Increased serum testosterone level","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012886","label":"Hemorrhagic ovarian cyst","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000138","label":"Ovarian cyst","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007430","label":"Generalized edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011106","label":"Hypovolemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012398","label":"Peripheral edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100598","label":"Pulmonary edema","frequency":"Occasional (29-5%)","criteria":null}]}}