ORPHA:623626
Paraneoplastic cerebellar degeneration
Synonyms: PCD · Paraneoplastic cerebellar ataxia · Rapidely progressive cerebellar syndrome · Subacute cerebellar degeneration
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Orphadata ships no English definition for this code.
1
Names in Orphadata languages
10 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Paraneoplastic cerebellar degeneration | PCD · Paraneoplastic cerebellar ataxia · Rapidely progressive cerebellar syndrome · Subacute cerebellar degeneration |
| fr | Dégénérescence cérébelleuse paranéoplasique | Ataxie cérébelleuse paranéoplasique · Ataxie cérébelleuse à progression rapide · Dégénérescence cérébelleuse subaiguë · Syndrome cérébelleux à progression rapide |
| de | Paraneoplastische zerebelläre Degeneration | PCD · Paraneoplastische zerebelläre Ataxie · Schnell fortschreitendes zerebelläres Syndrom · Subakute zerebelläre Degeneration |
| es | Degeneración cerebelosa paraneoplásica | Ataxia cerebelosa paraneoplásica · Degeneración cerebelosa subaguda · Síndrome cerebeloso rápidamente progresivo |
| it | Degenerazione cerebellare paraneoplastica | Atassia cerebellare paraneoplastica · Degenerazione cerebellare subacuta · PCD · Sindrome cerebellare a progressione rapida |
| nl | Paraneoplastische cerebellaire degeneratie | PCD · Paraneoplastische cerebellaire ataxie · Snel progressief cerebellair syndroom · Subacute cerebellaire degeneratie |
| pt | Degenerescência cerebelosa paraneoplásica | Ataxia cerebelosa paraneoplásica · Degenerescência cerebelosa subaguda · PCD · Síndrome cerebeloso com rápida progressão |
| pl | Paranowotworowe zwyrodnienie móżdżku | = en |
| cs | Paraneoplastická cerebelární degenerace | = en |
| uk | Паранеопластична дегенерація мозочка | Паранеопластична мозочкова атаксія · PCD · Швидко прогресуючий мозочковий синдром · Підгостра дегенерація мозочка |
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G31.8 | NTBT | attributed | validated |
| ICD-11 | 8E4A.0 | NTBT | index | validated |
| MONDO | 0044877 | E | validated | |
| MeSH | D020362 | E | validated | |
| UMLS | C0393534 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:623638Immune-mediated cerebellar ataxia
rare neurological diseases - ORPHA:36388Paraneoplastic neurologic syndrome
rare neurological diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
6 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | 0.9553 / 100 000 | Europe | Value and class | Validated | 31552550[PMID]_32847939[PMID]_ORPHANET |
| Annual incidence | 1-9 / 1 000 000 | 0.2225 / 100 000 | Europe | Value and class | Validated | 31552550[PMID]_32847939[PMID]_ORPHANET |
| Point prevalence | 1-9 / 1 000 000 | 0.6869 / 100 000 | France | Value and class | Validated | 32847939[PMID]_ORPHANET |
| Annual incidence | 1-9 / 1 000 000 | 0.16 / 100 000 | France | Value and class | Validated | 32847939[PMID]_ORPHANET |
| Point prevalence | 1-9 / 100 000 | 1.2236 / 100 000 | Italy | Value and class | Validated | 31552550[PMID] |
| Annual incidence | 1-9 / 1 000 000 | 0.285 / 100 000 | Italy | Value and class | Validated | 31552550[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
6
HPO phenotypes
24 annotations · validated 2024-10-30| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0001251 | Ataxia | |
| HP:6000397 | CSF oligoclonal immunoglobulin G bands | |
| HP:0012229 | CSF pleocytosis | |
| HP:0002922 | Increased CSF protein concentration | |
| Occasional (29-5%) | ||
| HP:5000006 | Anti-CV2/CRMP5 antibody positivity | |
| HP:5000016 | Anti-Hu antibody positivity | |
| HP:5000030 | Anti-Ri antibody | |
| HP:5000034 | Anti-Tr/DNER antibody | |
| HP:5000037 | Anti-Yo antibody positivity | |
| HP:5000024 | Anti-mGluR1 antibody | |
| HP:0001272 | Cerebellar atrophy | |
| HP:0100543 | Cognitive impairment | |
| HP:0000651 | Diplopia | |
| HP:0001260 | Dysarthria | |
| HP:0002015 | Dysphagia | |
| HP:0002315 | Headache | |
| HP:0012189 | Hodgkin lymphoma | |
| HP:0011134 | Low-grade fever | |
| HP:0033834 | Malaise | |
| HP:0002017 | Nausea and vomiting | |
| HP:0100013 | Neoplasm of the breast | |
| HP:0000639 | Nystagmus | |
| HP:0100615 | Ovarian neoplasm | |
| HP:0002317 | Unsteady gait | |
Annotation source: 32809473[PMID]_34827413[PMID]
7
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/623626
- This record as JSON: /data/d/623626.json