Twin-reversed arterial perfusion sequence
Synonyms: TRAP
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Antenatal
- Status
- active
A rare disorder related to monochorionic twin pregnancy characterized by complete or partial absence of cardiac development in one twin (''acardiac twin'') and blood supply of both circulations by the morphologically normal co-twin (''pump twin'') via an arterioarterial anastomosis. In most cases, the acardiac twin has well developed legs and pelvis but no cephalic pole, thoracic organs, and upper extremities. The condition is associated with a high risk of perinatal death of the pump twin due to a combination of high-output cardiac failure and polyhydramnios-related pre-term birth. Hypoxia and intrauterine growth restriction are also seen in the pump twin.
Names in Orphadata languages
10 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Twin-reversed arterial perfusion sequence | TRAP |
| fr | Séquence de perfusion artérielle inversée | Séquence TRAP · Séquence de perfusion artérielle inversée gémellaire |
| de | Umgekehrte arterielle Perfusionssequenz bei Zwillingen | TRAP-Sequenz |
| es | Secuencia de perfusión arterial reversa en gemelos | = en |
| it | Sequenza da perfusione arteriosa inversa tra gemelli | = en |
| nl | Omgekeerde arteriële perfusie bij tweeling-sequentie | Acardiacus-tweelingzwangerschap · TRAP · Twin reversed arterial perfusion-sequentie |
| pt | Sequência gemelar de perfusão arterial inversa | = en |
| pl | Zespół odwróconej perfuzji tętniczej u bliźniąt | = en |
| cs | Sekvence reverzní arteriální perfuze u dvojčat (TRAP) | = en |
| uk | Послідовність оборотної артеріальної перфузії у близнюків | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | O43.0 | NTBT | attributed | validated |
| ICD-11 | KA02.4 | NTBT | attributed | validated |
| MONDO | 0850014 | E | validated | |
| UMLS | C5575500 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:617310Rare disorder due to unbalanced inter-twin blood transfusion
rare gynecological and obstetric diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | 20522408[PMID]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/617297
- This record as JSON: /data/d/617297.json