Upper tract urothelial carcinoma
Synonyms: Transitional cell carcinoma of the pelvis and ureter · Transitional cell carcinoma of the upper urinary tract · UTUC
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- No data available
- Status
- active
A rare urinary tract tumor characterized by a malignant neoplasm arising from urothelial cells of the pyelocaliceal cavities and ureter. The tumor may be multifocal and bilateral in some cases and is more common in males than in females. Cigarette smoking and occupational exposure are major risk factors. Patients most commonly present with visible or non-visible hematuria and/or flank pain due to obstruction of the flow of urine by tumor tissue, or (less often) to local tumor growth. Systemic symptoms such as anorexia, weight loss, malaise, fatigue, fever, night sweats, or cough can be associated with advanced stages.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Upper tract urothelial carcinoma | Transitional cell carcinoma of the pelvis and ureter · Transitional cell carcinoma of the upper urinary tract · UTUC |
| fr | Cancer urothélial des voies supérieures | Carcinome urothélial des voies supérieures · Carcinome à cellules transitionnelles des voies urinaires supérieures · Carcinome à cellules transitionnelles du pelvis et de l'uretère |
| de | Urothelkarzinom des oberen Harntraktes | Transitionalzellkarzinom des Nierenbeckens und der Harnleiter · UTUC |
| es | Carcinoma urotelial de las vías urinarias superiores | CU-VUS · Carcinoma de células transicionales de la pelvis y el uréter · Carcinoma de células transicionales de las vías urinarias superiores |
| it | Carcinoma uroteliale del tratto superiore | Carcinoma della pelvi e dell'uretere a cellule transizionali · Carcinoma delle vie urinarie superiori a cellule transizionali · UTUC |
| nl | Urotheelcarcinoom van hogere urinewegen | Overgangscelcarcinoom van hogere urinewegen · Overgangscelcarcinoom van pelvis en ureter · Overgangsepitheelcarcinoom van bekken en urineleider · UTUC |
| pt | Carcinoma urotelial do tracto superior | Carcinoma de células transicionais da pélvis e ureter · Carcinoma de células transicionais do tracto urinário superior |
| pl | Rak urotelialny górnych dróg moczowych | UTUC · Rak przejściowokomórkowy górnych dróg moczowych |
| cs | Uroteliální karcinom horních cest močových | = en |
| uk | Уротеліальна карцинома верхніх відділів травного тракту | Перехідно-клітинна карцинома малого тазу та сечоводу · Перехідно-клітинна карцинома верхніх сечових шляхів · UTUC |
| zh | Upper tract urothelial carcinoma | = en |
| tr | Upper tract urothelial carcinoma | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C65 | BTNT | attributed | validated |
| ICD-10 | C66 | BTNT | attributed | validated |
| ICD-11 | 2C91.0 | NTBT | attributed | validated |
| ICD-11 | 2C92.0 | NTBT | attributed | validated |
| MONDO | 0020659 | E | validated | |
| UMLS | C0220648 | E | validated | |
| GARD | 9376 | E | validated | |
| MedDRA | 10044407 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98058Rare urinary tract tumor
rare urogenital diseases; rare neoplastic diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
| Annual incidence | 1-9 / 100 000 | 1.5 / 100 000 | Worldwide | Value and class | Validated | 28543959[PMID]_32593530[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/598216
- This record as JSON: /data/d/598216.json