raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:549

Legionnaires disease

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

A rare form of Legionellosis characterized by a severe, potentially fatal, pneumonia.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enLegionnaires disease
frMaladie du légionnaire
deLegionärskrankheit
esEnfermedad de los legionariosEnfermedad del legionario
itMalattia del legionarioLegionellosi
nlVeteranenziekteLegionellapneumonie
ptDoença do LegionárioLegionelose
plChoroba legionistówLegionelloza
csLegionářská nemoc
ukХвороба легіонерів
zh军团菌病军团病
trLejyonellozLejyoner hastalığı

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10A48.1Especificvalidated
ICD-111C19.1Especificvalidated
MONDO5824Evalidated
MeSHD007877Evalidated
UMLSC0023241Evalidated
GARD6876Evalidated
MedDRA10035718Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

31 records
TypeClassValueAreaQualificationValidationSource
Annual incidence1-9 / 100 0001.4 / 100 000EuropeValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0002.5 / 100 000FranceValue and classValidated21109475[PMID]
Annual incidence<1 / 1 000 0000.02 / 100 000RomaniaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.42 / 100 000CyprusValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.24 / 100 000Czech RepublicValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0003.18 / 100 000DenmarkValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.84 / 100 000EstoniaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.32 / 100 000FinlandValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.18 / 100 000GermanyValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.3 / 100 000GreeceValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.5 / 100 000HungaryValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.83 / 100 000IcelandValue and classValidatedEuropean Centre for Disease prevention and Control 2014-2017[OTHER]
Annual incidence1-9 / 1 000 0000.28 / 100 000IrelandValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0002.72 / 100 000ItalyValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.5 / 100 000LatviaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.28 / 100 000LithuaniaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.02 / 100 000LuxembourgValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.88 / 100 000MaltaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0002.48 / 100 000NetherlandsValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.96 / 100 000NorwayValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 0000.06 / 100 000PolandValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0002.42 / 100 000PortugalValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.26 / 100 000SlovakiaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0004.38 / 100 000SloveniaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0002.16 / 100 000SpainValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.52 / 100 000SwedenValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.62 / 100 000United KingdomValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.82 / 100 000AustriaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.38 / 100 000BelgiumValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.8 / 100 000CroatiaValue and classValidatedEuropean Centre for Disease prevention and Control 2014-2017[OTHER]
Annual incidence1-9 / 100 0005.4 / 100 000New ZealandValue and classValidated31294928[PMID]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

42 annotations · validated 2016-06-01
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0002088Abnormal lung morphology
HP:0012735Cough
HP:0012378Fatigue
HP:0001945Fever
HP:0003326Myalgia
HP:0002113Pulmonary infiltrates
Frequent (79-30%)
HP:0011675Arrhythmia
HP:0100749Chest pain
HP:0002093Respiratory insufficiency
Occasional (29-5%)
HP:0002027Abdominal pain
HP:0002103Abnormality of the pleura
HP:0002039Anorexia
HP:0002829Arthralgia
HP:0001251Ataxia
HP:0005528Bone marrow hypocellularity
HP:0100658Cellulitis
HP:0002014Diarrhea
HP:0100584Endocarditis
HP:0000738Hallucinations
HP:0000790Hematuria
HP:0002105Hemoptysis
HP:0012115Hepatitis
HP:0002902Hyponatremia
HP:0002615Hypotension
HP:0002383Infectious encephalitis
HP:0000952Jaundice
HP:0002716Lymphadenopathy
HP:0001888Lymphopenia
HP:0002076Migraine
HP:0001324Muscle weakness
HP:0012819Myocarditis
HP:0002017Nausea and vomiting
HP:0001733Pancreatitis
HP:0001701Pericarditis
HP:0009830Peripheral neuropathy
HP:0000093Proteinuria
HP:0100776Recurrent pharyngitis
HP:0004372Reduced consciousness
HP:0000083Renal insufficiency
HP:0002091Restrictive ventilatory defect
HP:0100806Sepsis
HP:0001744Splenomegaly

Run the differential on the 6 obligate / very frequent terms

7

Sources for this card