{"orpha":549,"name":"Legionnaires disease","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare form of Legionellosis characterized by a severe, potentially fatal, pneumonia.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-549/","orphanet_url":"https://www.orpha.net/en/disease/detail/549","names":{"fr":{"name":"Maladie du légionnaire","definition":"La légionellose ou maladie du légionnaire (ML) est une infection pulmonaire bactérienne caractérisée par une pneumonie parfois mortelle."},"de":{"name":"Legionärskrankheit","definition":"Eine seltene Form der Legionellose, die durch eine schwere, potenziell tödliche Lungenentzündung gekennzeichnet ist."},"es":{"name":"Enfermedad de los legionarios","synonyms":["Enfermedad del legionario"],"definition":"Es una forma poco frecuente de legionelosis caracterizada por neumonía grave y potencialmente fatal."},"it":{"name":"Malattia del legionario","synonyms":["Legionellosi"],"definition":"La legionellosi o malattia del legionario (LD) è un'infezione polmonare batterica caratterizzata da una polmonite potenzialmente fatale."},"nl":{"name":"Veteranenziekte","synonyms":["Legionellapneumonie"],"definition":"Een zeldzame vorm van legionellose, gekenmerkt door een ernstige, mogelijk fatale longontsteking."},"pt":{"name":"Doença do Legionário","synonyms":["Legionelose"],"definition":"Forma rara de legionelose caracterizada por uma pneumonia grave e potencialmente fatal."},"pl":{"name":"Choroba legionistów","synonyms":["Legionelloza"],"definition":"Rzadka postać legionelozy charakteryzująca się ciężkim, potencjalnie śmiertelnym zapaleniem płuc."},"cs":{"name":"Legionářská nemoc"},"uk":{"name":"Хвороба легіонерів","definition":"A rare form of Legionellosis characterized by a severe, potentially fatal, pneumonia."},"zh":{"name":"军团菌病","synonyms":["军团病"]},"tr":{"name":"Lejyonelloz","synonyms":["Lejyoner hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"A48.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C19.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"424434722"},{"source":"MONDO","code":"5824","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D007877","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0023241","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6876","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10035718","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":600832,"name":"Legionella infection","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.4,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.5,"area":"France","status":"Validated","source":"21109475[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.42,"area":"Cyprus","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.24,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.18,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.84,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.32,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.18,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.3,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.5,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.83,"area":"Iceland","status":"Validated","source":"European Centre for Disease prevention and Control 2014-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.28,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.72,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.5,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.28,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.02,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.88,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.48,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.96,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.06,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.42,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.26,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.38,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.16,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.52,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.62,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.82,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.38,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.8,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2014-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":5.4,"area":"New Zealand","status":"Validated","source":"31294928[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0002088","label":"Abnormal lung morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002113","label":"Pulmonary infiltrates","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002093","label":"Respiratory insufficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002103","label":"Abnormality of the pleura","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001251","label":"Ataxia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005528","label":"Bone marrow hypocellularity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100658","label":"Cellulitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100584","label":"Endocarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000738","label":"Hallucinations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002902","label":"Hyponatremia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001888","label":"Lymphopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002076","label":"Migraine","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001733","label":"Pancreatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009830","label":"Peripheral neuropathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000093","label":"Proteinuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100776","label":"Recurrent pharyngitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002091","label":"Restrictive ventilatory defect","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001744","label":"Splenomegaly","frequency":"Occasional (29-5%)","criteria":null}]}}