Acute myeloid leukemia
Synonyms: AML · Acute myelogenous leukemia
- Type
- Clinical group
- Group
- Group of disorders
- Age of onset
- All ages
- Status
- active
A group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. They manifest by fever, pallor, anemia, hemorrhages and recurrent infections.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute myeloid leukemia | AML · Acute myelogenous leukemia |
| fr | Leucémie aiguë myéloïde | AML · LAM · LANL · Leucémie aiguë myéloblastique |
| de | Leukämie, akute myeloische | AML · Leukämie, akute nicht-lymphoblastische |
| es | Leucemia mieloide aguda | LMA · Leucemia mielógena aguda |
| it | Leucemia mieloide acuta | AML · Leucemia mielogena acuta |
| nl | Acute myeloïde leukemie | AML · Acute myelogene leukemie |
| pt | Leucemia mielóide aguda | AML · Leucemia mielogéna aguda |
| pl | Ostra białaczka szpikowa | AML · Ostra białaczka mielogeniczna |
| cs | Akutní myeloidní leukémie | AML |
| uk | Гострий мієлоїдний лейкоз | Гострий мієлогенний лейкоз · AML |
| zh | 急性髓性白血病 | 急性髓性白血病 |
| tr | Akut miyeloid lösemi | AML · Akut miyelojenöz lösemi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 601626 | E | validated | |
| ICD-10 | C92.0 | E | specific | validated |
| ICD-11 | 2A60 | E | specific | validated |
| MONDO | 0018874 | E | validated | |
| MONDO | 18874 | E | validated | |
| MeSH | D015470 | E | validated | |
| UMLS | C0023467 | E | validated | |
| GARD | 12757 | E | validated | |
| MedDRA | 10000880 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:171895Myeloid hemopathy
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
Children (6):
- ORPHA:86851Acute leukemia of ambiguous lineage
- ORPHA:86845Acute myeloid leukaemia with myelodysplasia-related features
- ORPHA:98277Acute myeloid leukemia with recurrent genetic anomaly
- ORPHA:319465Inherited acute myeloid leukemia
- ORPHA:86846Therapy related acute myeloid leukemia and myelodysplastic syndrome
- ORPHA:167714Unclassified acute myeloid leukemia
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
7 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 2.5 / 100 000 | Worldwide | Value and class | Validated | 17019734[PMID] |
| Point prevalence | 1-5 / 10 000 | 10 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2018[OTHER] |
| Annual incidence | 1-9 / 100 000 | 3.39 / 100 000 | Europe | Value and class | Validated | 22033323[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER] |
| Lifetime Prevalence | 1-5 / 10 000 | 10.98 / 100 000 | Europe | Value and class | Validated | 22033323[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER] |
| Annual incidence | 1-9 / 100 000 | 4.4 / 100 000 | France | Value and class | Validated | OTHERitut National du Cancer 2013[OTHER] |
| Annual incidence | 1-9 / 100 000 | 2.8 / 100 000 | Denmark | Value and class | Validated | 24039451[PMID] |
| Annual incidence | 1-9 / 100 000 | 3.7 / 100 000 | United States | Value and class | Validated | National Cancer OTHERitute 2010[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/519
- This record as JSON: /data/d/519.json