{"orpha":519,"name":"Acute myeloid leukemia","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":["AML","Acute myelogenous leukemia"],"definition":"A group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. They manifest by fever, pallor, anemia, hemorrhages and recurrent infections.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-519/","orphanet_url":"https://www.orpha.net/en/disease/detail/519","names":{"fr":{"name":"Leucémie aiguë myéloïde","synonyms":["AML","LAM","LANL","Leucémie aiguë myéloblastique"],"definition":"La leucémie aiguë myéloïde (LAM) représente un groupe de néoplasmes provenant des cellules précurseurs impliquées dans la différenciation de la lignée myéloïde. Tous sont caractérisés par une expansion clonale de blastes myéloïdes. La LAM se manifeste par une fièvre, une pâleur, une anémie, des hémorragies et des infections récurrentes."},"de":{"name":"Leukämie, akute myeloische","synonyms":["AML","Leukämie, akute nicht-lymphoblastische"]},"es":{"name":"Leucemia mieloide aguda","synonyms":["LMA","Leucemia mielógena aguda"],"definition":"Es un grupo de neoplasias con origen en células precursoras comprometidas con la diferenciación de la línea celular mieloide. Todas ellas se caracterizan por la expansión clonal de blastos mieloides. Se manifiestan con fiebre, palidez, anemia, hemorragias e infecciones recurrentes."},"it":{"name":"Leucemia mieloide acuta","synonyms":["AML","Leucemia mielogena acuta"]},"nl":{"name":"Acute myeloïde leukemie","synonyms":["AML","Acute myelogene leukemie"],"definition":"Een groep van neoplasma's die ontstaan uit voorlopercellen die differentiëren volgens de myeloïde cellijn. Ze worden allen gekarakteriseerd door klonale toename van myeloïde blastcellen. Ze manifesteren zich met koorts, bleekheid, anemie, bloedingen en terugkerende infecties."},"pt":{"name":"Leucemia mielóide aguda","synonyms":["AML","Leucemia mielogéna aguda"]},"pl":{"name":"Ostra białaczka szpikowa","synonyms":["AML","Ostra białaczka mielogeniczna"]},"cs":{"name":"Akutní myeloidní leukémie","synonyms":["AML"]},"uk":{"name":"Гострий мієлоїдний лейкоз","synonyms":["Гострий мієлогенний лейкоз","AML"],"definition":"A group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. They manifest by fever, pallor, anemia, hemorrhages and recurrent infections."},"zh":{"name":"急性髓性白血病","synonyms":["急性髓性白血病"]},"tr":{"name":"Akut miyeloid lösemi","synonyms":["AML","Akut miyelojenöz lösemi"]}},"xrefs":[{"source":"OMIM","code":"601626","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"C92.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"2A60","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"8864887"},{"source":"MONDO","code":"0018874","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"18874","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D015470","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0023467","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"12757","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10000880","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":171895,"name":"Myeloid hemopathy","classifications":[194,202,233]}],"children":[{"orpha":86851,"name":"Acute leukemia of ambiguous lineage","type":"Category"},{"orpha":86845,"name":"Acute myeloid leukaemia with myelodysplasia-related features","type":"Disease"},{"orpha":98277,"name":"Acute myeloid leukemia with recurrent genetic anomaly","type":"Category"},{"orpha":319465,"name":"Inherited acute myeloid leukemia","type":"Disease"},{"orpha":86846,"name":"Therapy related acute myeloid leukemia and myelodysplastic syndrome","type":"Category"},{"orpha":167714,"name":"Unclassified acute myeloid leukemia","type":"Category"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.5,"area":"Worldwide","status":"Validated","source":"17019734[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":10.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2018[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.39,"area":"Europe","status":"Validated","source":"22033323[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Lifetime Prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":10.98,"area":"Europe","status":"Validated","source":"22033323[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.4,"area":"France","status":"Validated","source":"OTHERitut National du Cancer 2013[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.8,"area":"Denmark","status":"Validated","source":"24039451[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.7,"area":"United States","status":"Validated","source":"National Cancer OTHERitute 2010[OTHER]"}],"phenotypes":null}