Acute lymphoblastic leukemia
Synonyms: ALL · Acute lymphoblastic leukemia/lymphoma · Acute lymphocytic leukemia · Precursor lymphoid neoplasm
- Type
- Clinical group
- Group
- Group of disorders
- Age of onset
- All ages
- Status
- active
A group of rare Non-Hodgkin lymphoma characterized by malignant proliferation of lymphoid cells blocked at an early stage of differentiation. It accounts for 75% of all cases of childhood leukemia cases. The peak incidence occurs between 2 and 5 years of age. Patients may present with symptoms, frequently including lymphadenopathy, hepatosplenomegaly, bone pain, fever and signs of hemorrhage or they may remain asymptomatic. Some patients may also present with acute with a life-threatening hemorrhage, infection, or respiratory distress. Although it primarily affects the bone marrow and peripheral blood, the abnormal cells can infiltrate any organ or tissue.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute lymphoblastic leukemia | ALL · Acute lymphoblastic leukemia/lymphoma · Acute lymphocytic leukemia · Precursor lymphoid neoplasm |
| fr | Leucémie lymphoblastique aiguë | ALL · LAL · Leucémie/lymphome lymphoblastique aiguë · Leucémie/lymphome lymphocytique aiguë |
| de | Leukämie, akute lymphoblastische | ALL · Akute lymphoblastische Leukämie/Lymphom · Leukämie, akute lymphozytische · Lymphatische Vorläufer-Neoplasie |
| es | Leucemia linfoblástica aguda | Leucemia linfocítica aguda · Leucemia/linfoma linfoblástico agudo · Neoplasia de células precursoras linfoides · LLA |
| it | Leucemia linfoblastica acuta | ALL · Leucemia linfocitica acuta · Leucemia/linfoma linfoblastica acuta |
| nl | Acute lymfoblastische leukemie | ALL · Acute lymfatische leukemie · Acute lymfoblastenleukemie · Acute lymfoblastische leukemie/lymfoom · Acute lymfocytische leukemie · Neoplasma van lymfoïde progenitorcel |
| pt | Leucemia linfoblástica aguda | |
| pl | Ostra białaczka limfoblastyczna | ALL · Ostra białaczka limfoblastyczna · Ostra białaczka/chłoniak limfoblastycza |
| cs | Akutní lymfoblastická leukémie | ALL · Akutní lymfoblastická leukémie/lymfom · Akutní lymfotická leukémie |
| uk | Гострий лімфобластний лейкоз | Гострий лімфобластний лейкоз/лімфома · Гострий лімфоцитарний лейкоз · ALL · Пухлина лімфоїдного попередника |
| zh | 急性淋巴细胞性白血病 | 急性淋巴细胞白血病/淋巴瘤 |
| tr | Akut lenfoblastik lösemi | ALL · Akut lenfositik lösemi · Akut lenfoblastik lösemi/lenfoma |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 247640 | BTNT | validated | |
| OMIM | 613065 | E | validated | |
| OMIM | 613067 | BTNT | validated | |
| ICD-10 | C91.0 | E | specific | validated |
| MONDO | 0004967 | E | validated | |
| MONDO | 4967 | E | validated | |
| MeSH | D054198 | E | validated | |
| UMLS | C1961102 | E | validated | |
| GARD | 522 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:547Non-Hodgkin lymphoma
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
5 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 2.75 / 100 000 | Europe | Value and class | Not yet validated | ORPHANET |
| Annual incidence | 1-9 / 100 000 | 1.3 / 100 000 | France | Value and class | Validated | OTHERitut National du Cancer 2013[OTHER] |
| Annual incidence | 1-9 / 100 000 | 1.6 / 100 000 | United States | Value and class | Validated | National Cancer OTHERitute[OTHER]_23523389[PMID] |
| Lifetime Prevalence | 1-5 / 10 000 | 22 / 100 000 | United States | Value and class | Validated | National Cancer OTHERitute 2009[OTHER] |
| Point prevalence | 1-5 / 10 000 | 11 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2005[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/513
- This record as JSON: /data/d/513.json