{"orpha":513,"name":"Acute lymphoblastic leukemia","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":["ALL","Acute lymphoblastic leukemia/lymphoma","Acute lymphocytic leukemia","Precursor lymphoid neoplasm"],"definition":"A group of rare Non-Hodgkin lymphoma characterized by malignant proliferation of lymphoid cells blocked at an early stage of differentiation. It accounts for 75% of all cases of childhood leukemia cases. The peak incidence occurs between 2 and 5 years of age. Patients may present with symptoms, frequently including lymphadenopathy, hepatosplenomegaly, bone pain, fever and signs of hemorrhage or they may remain asymptomatic. Some patients may also present with acute with a life-threatening hemorrhage, infection, or respiratory distress. Although it primarily affects the bone marrow and peripheral blood, the abnormal cells can infiltrate any organ or tissue.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-513/","orphanet_url":"https://www.orpha.net/en/disease/detail/513","names":{"fr":{"name":"Leucémie lymphoblastique aiguë","synonyms":["ALL","LAL","Leucémie/lymphome lymphoblastique aiguë","Leucémie/lymphome lymphocytique aiguë"],"definition":"Les leucémies aiguës lymphoblastiques (LAL) sont des proliférations malignes de cellules lymphoïdes bloquées à un stade précoce de différenciation ; elles représentent 75% des cas de leucémies de l'enfant."},"de":{"name":"Leukämie, akute lymphoblastische","synonyms":["ALL","Akute lymphoblastische Leukämie/Lymphom","Leukämie, akute lymphozytische","Lymphatische Vorläufer-Neoplasie"],"definition":"Die Akute Lymphoblastenleukämie (ALL) ist eine maligne Proliferation lymphoider Zellen, deren Differenzierung auf einer frühen Stufe blockiert ist. Sie macht 75% aller Leukämien des Kindesalters aus."},"es":{"name":"Leucemia linfoblástica aguda","synonyms":["Leucemia linfocítica aguda","Leucemia/linfoma linfoblástico agudo","Neoplasia de células precursoras linfoides","LLA"],"definition":"Es una enfermedad poco frecuente caracterizada por la proliferación maligna de células linfoides detenidas en una etapa temprana de diferenciación y representa el 75% de todos los casos de leucemia infantil."},"it":{"name":"Leucemia linfoblastica acuta","synonyms":["ALL","Leucemia linfocitica acuta","Leucemia/linfoma linfoblastica acuta"]},"nl":{"name":"Acute lymfoblastische leukemie","synonyms":["ALL","Acute lymfatische leukemie","Acute lymfoblastenleukemie","Acute lymfoblastische leukemie/lymfoom","Acute lymfocytische leukemie","Neoplasma van lymfoïde progenitorcel"],"definition":"Een zeldzame ziekte, gekenmerkt door maligne proliferatie van lymfoïde cellen geblokkeerd in een vroeg differentiatiestadium, en goed voor 75% van alle gevallen van leukemie in de kindertijd."},"pt":{"name":"Leucemia linfoblástica aguda"},"pl":{"name":"Ostra białaczka limfoblastyczna","synonyms":["ALL","Ostra białaczka limfoblastyczna","Ostra białaczka/chłoniak limfoblastycza"]},"cs":{"name":"Akutní lymfoblastická leukémie","synonyms":["ALL","Akutní lymfoblastická leukémie/lymfom","Akutní lymfotická leukémie"]},"uk":{"name":"Гострий лімфобластний лейкоз","synonyms":["Гострий лімфобластний лейкоз/лімфома","Гострий лімфоцитарний лейкоз","ALL","Пухлина лімфоїдного попередника"],"definition":"A rare disease characterized by malignant proliferation of lymphoid cells blocked at an early stage of differentiation and accounts for 75% of all cases of childhood leukaemia."},"zh":{"name":"急性淋巴细胞性白血病","synonyms":["急性淋巴细胞白血病/淋巴瘤"]},"tr":{"name":"Akut lenfoblastik lösemi","synonyms":["ALL","Akut lenfositik lösemi","Akut lenfoblastik lösemi/lenfoma"]}},"xrefs":[{"source":"OMIM","code":"247640","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"OMIM","code":"613065","qualifier":"E","icd_relation":null,"validated":true},{"source":"OMIM","code":"613067","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"C91.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"MONDO","code":"0004967","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"4967","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D054198","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1961102","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"522","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":547,"name":"Non-Hodgkin lymphoma","classifications":[194,202,233]}],"children":[{"orpha":99860,"name":"Precursor B-cell acute lymphoblastic leukemia","type":"Disease"},{"orpha":99861,"name":"Precursor T-cell acute lymphoblastic leukemia","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.75,"area":"Europe","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.3,"area":"France","status":"Validated","source":"OTHERitut National du Cancer 2013[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.6,"area":"United States","status":"Validated","source":"National Cancer OTHERitute[OTHER]_23523389[PMID]"},{"type":"Lifetime Prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":22.0,"area":"United States","status":"Validated","source":"National Cancer OTHERitute 2009[OTHER]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":11.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2005[OTHER]"}],"phenotypes":null}