ORPHA:509
Leptospirosis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
An anthropozoonosis, rare in Europe, clinically characterized by an initial presentation of flu-like symptoms rapidly progressing into life-threatening multisystem failure (notably hepatonephritis) caused by spiral-shaped bacteria belonging to the genus <i>Leptospira</i>. Leptospirosis is a widespread zoonosis with a worldwide distribution and has emerged as a major public health problem in developing countries in South-East Asia and South America.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Leptospirosis | |
| fr | Leptospirose | |
| de | Leptospirose | |
| es | Leptospirosis | |
| it | Leptospirosi | |
| nl | Leptospirose | |
| pt | Leptospirose | |
| pl | Leptospiroza | |
| cs | Leptospiróza | |
| uk | Лептоспіроз | |
| zh | 钩端螺旋体病 | |
| tr | Leptospiroz |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A27.0 | BTNT | specific | validated |
| ICD-10 | A27.8 | BTNT | specific | validated |
| ICD-10 | A27.9 | BTNT | specific | validated |
| ICD-11 | 1B91 | E | specific | validated |
| MONDO | 0005825 | E | validated | |
| MeSH | D007922 | E | validated | |
| UMLS | C0023364 | E | validated | |
| GARD | 7881 | E | validated | |
| MedDRA | 10024238 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163582Rare bacterial infectious disease
rare infectious diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
27 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Europe | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Point prevalence | 1-9 / 1 000 000 | — | Europe | Class only | Not yet validated | ORPHANET |
| Annual incidence | 1-9 / 1 000 000 | 0.92 / 100 000 | France | Value and class | Validated | 23337900[PMID] |
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Austria | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Belgium | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.18 / 100 000 | Bulgaria | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 100 000 | 1.13 / 100 000 | Croatia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.22 / 100 000 | Czech Republic | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Denmark | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.24 / 100 000 | Estonia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Finland | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Germany | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.22 / 100 000 | Greece | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.16 / 100 000 | Hungary | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.36 / 100 000 | Ireland | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.1 / 100 000 | Italy | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.14 / 100 000 | Latvia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.3 / 100 000 | Lithuania | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.04 / 100 000 | Luxembourg | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.42 / 100 000 | Malta | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.36 / 100 000 | Netherlands | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.38 / 100 000 | Portugal | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.38 / 100 000 | Romania | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Slovakia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.52 / 100 000 | Slovenia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.04 / 100 000 | Sweden | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.1 / 100 000 | United Kingdom | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
40 annotations · validated 2019-10-09| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0002039 | Anorexia | |
| HP:0002829 | Arthralgia | |
| HP:0030953 | Conjunctival hyperemia | |
| HP:0008150 | Elevated serum transaminases during infections | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0002152 | Hyperproteinemia | |
| HP:0002615 | Hypotension | |
| HP:0003326 | Myalgia | |
| HP:0002017 | Nausea and vomiting | |
| HP:0001873 | Thrombocytopenia | |
| Occasional (29-5%) | ||
| HP:0001919 | Acute kidney injury | |
| HP:0031197 | Cellular urinary casts | |
| HP:0025143 | Chills | |
| HP:0012735 | Cough | |
| HP:0002014 | Diarrhea | |
| HP:0011705 | First degree atrioventricular block | |
| HP:0002105 | Hemoptysis | |
| HP:0012115 | Hepatitis | |
| HP:0002240 | Hepatomegaly | |
| HP:0000952 | Jaundice | |
| HP:0002716 | Lymphadenopathy | |
| HP:0001287 | Meningitis | |
| HP:0002011 | Morphological central nervous system abnormality | |
| HP:0025439 | Pharyngitis | |
| HP:0002202 | Pleural effusion | |
| HP:0040223 | Pulmonary hemorrhage | |
| HP:0002098 | Respiratory distress | |
| HP:0000988 | Skin rash | |
| Very rare (<4-1%) | ||
| HP:0011675 | Arrhythmia | |
| HP:0012424 | Chorioretinitis | |
| HP:0030497 | Macular cotton wool spot | |
| HP:0100653 | Optic neuritis | |
| HP:0001085 | Papilledema | |
| HP:0001701 | Pericarditis | |
| HP:0000573 | Retinal hemorrhage | |
| HP:0003201 | Rhabdomyolysis | |
| HP:0011896 | Subconjunctival hemorrhage | |
| HP:0000554 | Uveitis | |
Annotation source: 31583866[PMID]_14652202[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/509
- This record as JSON: /data/d/509.json