{"orpha":509,"name":"Leptospirosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"An anthropozoonosis, rare in Europe, clinically characterized by an initial presentation of flu-like symptoms rapidly progressing into life-threatening multisystem failure (notably hepatonephritis) caused by spiral-shaped bacteria belonging to the genus <i>Leptospira</i>. Leptospirosis is a widespread zoonosis with a worldwide distribution and has emerged as a major public health problem in developing countries in South-East Asia and South America.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-509/","orphanet_url":"https://www.orpha.net/en/disease/detail/509","names":{"fr":{"name":"Leptospirose","definition":"Anthropozoonose rare en Europe, caractérisée sur le plan clinique par la présentation initiale de symptômes pseudo-grippaux évoluant rapidement vers une défaillance multisystémique potentiellement mortelle (notamment une hépatonéphrite), causée par des bactéries de forme hélicoïdale appartenant au genre <i>Leptospira</i>. Répandue dans le monde entier, la leptospirose est une zoonose qui est devenue un problème majeur de santé publique dans les pays en développement d'Asie du Sud-Est et d'Amérique du Sud."},"de":{"name":"Leptospirose","definition":"Eine in Europa seltene Anthropozoonose, die klinisch durch anfänglich grippeähnliche Symptome gekennzeichnet ist, die sich rasch zu einem lebensbedrohlichen Multisystemversagen (insbesondere Hepatonephritis) entwickeln, das durch spiralförmige Bakterien der Gattung <i>Leptospira</i> verursacht wird. Die Leptospirose ist eine weit verbreitete Zoonose mit weltweiter Verbreitung und hat sich in Entwicklungsländern in Südostasien und Südamerika zu einem großen Problem für die öffentliche Gesundheit entwickelt."},"es":{"name":"Leptospirosis","definition":"Es una antropozoonosis, poco frecuente en Europa, caracterizada clínicamente por una presentación inicial de síntomas similares a los de la gripe que progresan rápidamente hacia un fallo multisistémico potencialmente mortal (en particular, hepatonefritis) causada por bacterias en forma de espiral pertenecientes al género <i>Leptospira</i>. La leptospirosis es una zoonosis con distribución mundial muy extendida que se ha convertido en un importante problema de salud pública en los países en desarrollo del sudeste de Asia y de América del Sur."},"it":{"name":"Leptospirosi"},"nl":{"name":"Leptospirose","definition":"Een antropozoönose, zeldzaam in Europa, klinisch gekenmerkt door een initiële presentatie van griepachtige symptomen met snelle progressie naar levensbedreigend multisysteemfalen (in het bijzonder hepatonefritis) veroorzaakt door spiraalvormige bacteriën die behoren tot het geslacht <i>Leptospira</i>. Leptospirose is een wijdverspreide zoönose met een wereldwijde distributie, en vormt een groot probleem voor de publieke gezondheid in ontwikkelingslanden in Zuidoost-Azië en Zuid-Amerika."},"pt":{"name":"Leptospirose","definition":"Antropozoonose, rara na Europa, clinicamente caracterizada por uma apresentação inicial de sintomas semelhantes aos da gripe, progredindo rapidamente para uma falha multissistémica com risco de vida (em particular hepatonefrite) causada por bactérias em forma de espiral pertencentes ao género Leptospira. A leptospirose é uma zoonose disseminada com distribuição mundial e surgiu como um grande problema de saúde pública em países em desenvolvimento no Sudeste Asiático e América do Sul."},"pl":{"name":"Leptospiroza"},"cs":{"name":"Leptospiróza"},"uk":{"name":"Лептоспіроз","definition":"Leptospirosis is an anthropozoonosis caused by spiral-shaped bacteria belonging to the genus Leptospira. Leptospirosis is a widespread zoonosis with a worldwide distribution and has emerged as a major public health problem in developing countries in South-East Asia and South America."},"zh":{"name":"钩端螺旋体病"},"tr":{"name":"Leptospiroz"}},"xrefs":[{"source":"ICD-10","code":"A27.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A27.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A27.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1B91","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"751399056"},{"source":"MONDO","code":"0005825","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D007922","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0023364","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7881","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10024238","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 1 000 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.92,"area":"France","status":"Validated","source":"23337900[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.18,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.13,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.22,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.24,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.22,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.16,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.36,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.14,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.3,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.42,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.36,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.38,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.38,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.52,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-10-09","source":"31583866[PMID]_14652202[PMID]","terms":[{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030953","label":"Conjunctival hyperemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008150","label":"Elevated serum transaminases during infections","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002152","label":"Hyperproteinemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031197","label":"Cellular urinary casts","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011705","label":"First degree atrioventricular block","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002011","label":"Morphological central nervous system abnormality","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040223","label":"Pulmonary hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012424","label":"Chorioretinitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030497","label":"Macular cotton wool spot","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100653","label":"Optic neuritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001085","label":"Papilledema","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000573","label":"Retinal hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011896","label":"Subconjunctival hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000554","label":"Uveitis","frequency":"Very rare (<4-1%)","criteria":null}]}}