Leishmaniasis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A parasitic disease caused by protozoa of the genus <i>Leishmania</i> (>20 pathogenic species), transmitted by the bite of infected female phlebotomine sandflies. Three main syndromes are recognized: visceral (VL), cutaneous (CL; localized and diffuse forms) and mucocutaneous leishmaniasis. Post-kala-azar dermal leishmaniasis (PKDL) is a cutaneous sequela of VL. Most infections remain asymptomatic.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Leishmaniasis | |
| fr | Leishmaniose | |
| de | Leishmaniose | |
| es | Leishmaniasis | Leishmaniosis |
| it | Leishmaniosi | |
| nl | Leishmaniasis | Leishmaniase |
| pt | Leishmaniose | |
| pl | Leiszmanioza | |
| cs | Leishmanióza | |
| uk | Лейшманіоз | |
| zh | 利什曼病 | |
| tr | Leşmanyaz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 608207 | E | validated | |
| ICD-10 | B55.0 | BTNT | specific | validated |
| ICD-10 | B55.1 | BTNT | specific | validated |
| ICD-10 | B55.2 | BTNT | specific | validated |
| ICD-10 | B55.9 | BTNT | specific | validated |
| ICD-11 | 1F54 | E | specific | validated |
| ICD-11 | 1F54.0 | BTNT | specific | validated |
| ICD-11 | 1F54.1 | BTNT | specific | validated |
| ICD-11 | 1F54.2 | BTNT | specific | validated |
| MONDO | 0011989 | E | validated | |
| MeSH | D007896 | E | validated | |
| UMLS | C0023281 | E | validated | |
| GARD | 6881 | E | validated | |
| MedDRA | 10024198 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163588Rare parasitic disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | 0.1 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2012[OTHER] |
| Annual incidence | 1-5 / 10 000 | 25 / 100 000 | Worldwide | Value and class | Validated | World Health Organization[OTHER]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
25 annotations · validated 2017-02-02| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001892 | Abnormal bleeding | |
| HP:0004311 | Abnormal macrophage morphology | |
| HP:0000163 | Abnormal oral cavity morphology | |
| HP:0011830 | Abnormal oral mucosa morphology | |
| HP:0002240 | Hepatomegaly | |
| HP:0002716 | Lymphadenopathy | |
| HP:0030166 | Night sweats | |
| HP:0001876 | Pancytopenia | |
| HP:0200034 | Papule | |
| HP:0001954 | Recurrent fever | |
| HP:0012384 | Rhinitis | |
| HP:0200035 | Skin plaque | |
| HP:0200042 | Skin ulcer | |
| HP:0001744 | Splenomegaly | |
| Frequent (79-30%) | ||
| HP:0001903 | Anemia | |
| HP:0002829 | Arthralgia | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0003073 | Hypoalbuminemia | |
| HP:0010702 | Increased circulating immunoglobulin concentration | |
| HP:0000980 | Pallor | |
| HP:0001824 | Weight loss | |
| Occasional (29-5%) | ||
| HP:0002039 | Anorexia | |
| HP:0012378 | Fatigue | |
| HP:0001882 | Leukopenia | |
| HP:0001873 | Thrombocytopenia | |
Run the differential on the 12 obligate / very frequent terms
Annotation source: 27004573[PMID]_27347283[PMID]_26682298[PMID]_26568335[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/507
- This record as JSON: /data/d/507.json