ORPHA:449285

Snakebite envenomation

Type: Disease
Group: Disorder
Inheritance: Not applicable
Age of onset: All ages
Status: active

A rare disorder due to poisoning caused by toxins in the bite of a venomous snake. Envenoming can also be caused by spraying of venom into the eyes. Depending on venom composition and other factors, consequences range from local tissue damage to potentially life-threatening systemic effects. Severe manifestations include paralysis, bleeding disorders, kidney failure, or permanent disability and limb amputation due to severe local tissue destruction. Children may suffer more severe effects because of their lower body mass. Immediate medical attention, in particular administration of antivenom, is critical.

Names in Orphadata languages

12 of 12 languages

Lang	Name	Synonyms
en	Snakebite envenomation
fr	Envenimation suite à une morsure de serpent
de	Schlangenbiss-Vergiftung
es	Envenenamiento por mordedura de serpiente
it	Avvelenamento da morso di serpente
nl	Vergiftiging door slangenbeet
pt	Envenenamento por mordedura de cobra
pl	Zatrucie spowodowane ukąszeniem węża
cs	Otrava hadím uštknutím
uk	Отруєння при укусі змії
zh	蛇咬中毒
tr	Yılan ısırığı zehirlenmesi

Definition in:

Cross-references

qualifier = Orphanet mapping relation

Source	Code	Qualifier	ICD relation	Validation
ICD-10	T63.0	E	specific	validated
ICD-11	NE61	NTBT	index	validated
MONDO	0018669	E		validated
MeSH	D012909	E		validated
UMLS	C0037379	E		validated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

Classification

Preferential parent (Orphanet linearisation):

ORPHA:108999Rare disorder due to toxic effects

Parents in the classifications (1):

ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects

No children.

Codes that Orphanet moved or referred to this one:

ORPHA:1939OBSOLETE: Envenomization by Bothrops lanceolatus referred to · inactive

Genes

0 direct

Orphanet records no gene directly on this code.

Prevalence and incidence

1 record

Type	Class	Value	Area	Qualification	Validation	Source
Point prevalence	1-9 / 100 000	—	Europe	Class only	Validated	European Medicines Agency 2015[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

HPO phenotypes

34 annotations · validated 2020-02-26

HPO	Term (as annotated by Orphanet)	Diagnostic
Very frequent (99-80%)
HP:0000969	Edema
Frequent (79-30%)
HP:0031364	Ecchymosis
HP:0010783	Erythema
HP:0011355	Localized skin lesion
HP:0012531	Pain
Occasional (29-5%)
HP:0001892	Abnormal bleeding
HP:0001928	Abnormality of coagulation
HP:0000707	Abnormality of the nervous system
HP:0002637	Cerebral ischemia
HP:0011900	Hypofibrinogenemia
HP:0002170	Intracranial hemorrhage
HP:0003713	Muscle fiber necrosis
HP:0003470	Paralysis
HP:0007024	Pseudobulbar paralysis
HP:0003201	Rhabdomyolysis
HP:0009088	Speech articulation difficulties
HP:0001297	Stroke
HP:0001649	Tachycardia
HP:0001873	Thrombocytopenia
HP:0002013	Vomiting
Very rare (<4-1%)
HP:0001919	Acute kidney injury
HP:0100665	Angioedema
HP:0030149	Cardiogenic shock
HP:0002014	Diarrhea
HP:0005521	Disseminated intravascular coagulation
HP:0000421	Epistaxis
HP:0000225	Gingival bleeding
HP:0002902	Hyponatremia
HP:0040075	Hypopituitarism
HP:0002615	Hypotension
HP:0001658	Myocardial infarction
HP:0002068	Neuromuscular dysphagia
HP:0002878	Respiratory failure
HP:0002203	Respiratory paralysis

Run the differential on the 1 obligate / very frequent terms

Annotation source: 28905944[PMID]_28975491[PMID]

Sources for this card

Orphanet page: orpha.net/en/disease/detail/449285
This record as JSON: /data/d/449285.json