{"orpha":449285,"name":"Snakebite envenomation","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare disorder due to poisoning caused by toxins in the bite of a venomous snake. Envenoming can also be caused by spraying of venom into the eyes. Depending on venom composition and other factors, consequences range from local tissue damage to potentially life-threatening systemic effects. Severe manifestations include paralysis, bleeding disorders, kidney failure, or permanent disability and limb amputation due to severe local tissue destruction. Children may suffer more severe effects because of their lower body mass. Immediate medical attention, in particular administration of antivenom, is critical.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-449285/","orphanet_url":"https://www.orpha.net/en/disease/detail/449285","names":{"fr":{"name":"Envenimation suite à une morsure de serpent","definition":"Maladie rare due à une intoxication provoquée par des toxines suite à une morsure de serpent venimeux. L'envenimation peut aussi être provoquée après vaporisation du venin dans les yeux. En fonction de la composition du venin et d'autres facteurs, les conséquences vont d'une atteinte des tissus locaux à des effets systémiques pouvant engager le pronostic vital. Les manifestations sévères comprennent paralysie, hémorragie, insuffisance rénale ou handicap permanent et amputation d'un membre en raison d'une destruction sévère des tissus locaux. Les conséquences peuvent être plus sévères chez les enfants en raison de leur plus faible masse corporelle. Une prise en charge médicale immédiate, notamment l'administration de sérums antivenimeux, est cruciale."},"de":{"name":"Schlangenbiss-Vergiftung","definition":"Eine seltene Erkrankung, die auf Vergiftungen durch Toxine im Biss einer Giftschlange zurückzuführen ist. Die Vergiftung kann auch durch das Versprühen von Gift in die Augen verursacht werden. Je nach Zusammensetzung des Giftes und anderen Faktoren reichen die Folgen von lokalen Gewebeschäden bis hin zu potenziell lebensbedrohlichen systemischen Auswirkungen. Zu den schwerwiegenden Erscheinungsformen gehören Lähmungen, Blutungsstörungen, Nierenversagen oder dauerhafte Behinderungen und Amputationen von Gliedmaßen aufgrund schwerer lokaler Gewebeschäden. Bei Kindern kann es aufgrund ihrer geringeren Körpermasse zu schwereren Auswirkungen kommen. Eine sofortige medizinische Behandlung, insbesondere die Verabreichung eines Gegengiftes, ist von entscheidender Bedeutung."},"es":{"name":"Envenenamiento por mordedura de serpiente","definition":"Es un trastorno poco frecuente debido al envenenamiento causado por toxinas por mordedura de una serpiente venenosa. El envenenamiento también puede estar causado por la pulverización de veneno en los ojos. Dependiendo de la composición del veneno y de otros factores, las consecuencias varían desde daño tisular local hasta efectos sistémicos potencialmente mortales. Las manifestaciones graves incluyen parálisis, trastornos hemorrágicos, insuficiencia renal o discapacidad permanente y amputación de extremidades debido a una destrucción grave del tejido local. Los niños pueden sufrir efectos más graves debido a su menor masa corporal. Es fundamental recibir atención médica inmediata, en particular la administración de un antídoto."},"it":{"name":"Avvelenamento da morso di serpente"},"nl":{"name":"Vergiftiging door slangenbeet","definition":"Een zeldzame aandoening door vergiftiging veroorzaakt door toxines in de beet van een giftige slang. Vergiftiging kan ook veroorzaakt worden door het sproeien van gif in de ogen. Afhankelijk van de samenstelling van het gif en andere factoren, gaan de gevolgen van lokale weefselschade tot potentieel levensbedreigende systemische effecten. Ernstige manifestaties zijn onder meer verlamming, stollingsstoornissen, nierfalen, of permanente invaliditeit en amputatie van ledematen vanwege ernstige lokale destructie van weefsel. Kinderen kunnen lijden aan ernstigere effecten vanwege hun lagere lichaamsgewicht. Onmiddellijke medische aandacht, vooral toediening van tegengif, is essentieel."},"pt":{"name":"Envenenamento por mordedura de cobra","definition":"Doença rara causada por envenenamento por toxinas presentes na mordedura de uma cobra venenosa. O envenenamento também pode ser causado pela pulverização de veneno nos olhos. Dependendo da composição do veneno e de outros fatores, as consequências variam desde danos locais nos tecidos a efeitos sistémicos potencialmente fatais. As manifestações graves incluem paralisia, distúrbios hemorrágicos, insuficiência renal ou incapacidade permanente e amputação de membros devido à destruição grave do tecido local. As crianças podem sofrer efeitos mais graves devido à menor massa corporal. Cuidados médicos imediatos, em particular a administração de antídoto, são fundamentais."},"pl":{"name":"Zatrucie spowodowane ukąszeniem węża","definition":"Rzadkie zaburzenie spowodowane zatruciem toksynami w wyniku ukąszenia jadowitego węża. Zatrucie może być również spowodowane rozpyleniem jadu do oczu. W zależności od składu jadu i innych czynników konsekwencje są różne, od miejscowego uszkodzenia tkanek po potencjalnie zagrażające życiu skutki ogólnoustrojowe. Poważne objawy obejmują paraliż, zaburzenia krwotoczne, niewydolność nerek lub trwałą niepełnosprawność i amputację kończyny z powodu poważnego miejscowego zniszczenia tkanki. U dzieci następstwa mogą być poważniejsze ze względu na mniejszą masę ciała. Niezbędna jest natychmiastowa pomoc lekarska, w szczególności podanie antytoksyny."},"cs":{"name":"Otrava hadím uštknutím"},"uk":{"name":"Отруєння при укусі змії","definition":"A rare disorder due to poisoning caused by toxins in the bite of a venomous snake. Envenoming can also be caused by spraying of venom into the eyes. Depending on venom composition and other factors, consequences range from local tissue damage to potentially life-threatening systemic effects. Severe manifestations include paralysis, bleeding disorders, kidney failure, or permanent disability and limb amputation due to severe local tissue destruction. Children may suffer more severe effects because of their lower body mass. Immediate medical attention, in particular administration of antivenom, is critical."},"zh":{"name":"蛇咬中毒"},"tr":{"name":"Yılan ısırığı zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T63.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"NE61","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"57961351"},{"source":"MONDO","code":"0018669","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012909","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0037379","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":1939,"name":"OBSOLETE: Envenomization by Bothrops lanceolatus","status":"inactive"}],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 100 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2015[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-02-26","source":"28905944[PMID]_28975491[PMID]","terms":[{"hpo":"HP:0000969","label":"Edema","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0031364","label":"Ecchymosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010783","label":"Erythema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011355","label":"Localized skin lesion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012531","label":"Pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001928","label":"Abnormality of coagulation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002637","label":"Cerebral ischemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011900","label":"Hypofibrinogenemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002170","label":"Intracranial hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003713","label":"Muscle fiber necrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003470","label":"Paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007024","label":"Pseudobulbar paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009088","label":"Speech articulation difficulties","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001297","label":"Stroke","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100665","label":"Angioedema","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030149","label":"Cardiogenic shock","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000421","label":"Epistaxis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000225","label":"Gingival bleeding","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002902","label":"Hyponatremia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0040075","label":"Hypopituitarism","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001658","label":"Myocardial infarction","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002068","label":"Neuromuscular dysphagia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002203","label":"Respiratory paralysis","frequency":"Very rare (<4-1%)","criteria":null}]}}