Zika virus disease
Synonyms: Zika virus infection
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Zika virus disease is an emerging <i>Aedes</i> mosquito-born virus disease characterized by a clinical course that may be asymptomatic or mild with fever, conjunctivitis, muscle and joint pain, headache, exanthema, but may also be associated with severe neurological (meningitis, meningoencephalitis and myelitis) and auto-immune (Guillain-Barre syndrome) complications, as well as a potential increase of birth defects (microcephaly) if the infection occurs during pregnancy.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Zika virus disease | Zika virus infection |
| fr | Maladie à virus Zika | Infection à virus Zika |
| de | Zikavirus-Infektion | Zika-Virus-Krankheit |
| es | Enfermedad por el virus de Zika | Infección por el virus de Zika |
| it | Malattia del virus Zika | Infezione da virus Zika |
| nl | Ziekte door zikavirus | Infectie door zikavirus |
| pt | Doença do vírus Zika | Infecção virus Zika |
| pl | Choroba wywołana przez wirus Zika | Zakażenie wirusem Zika |
| cs | Onemocnění virem Zika | Infekce virem Zika · Zika |
| uk | Хвороба, спричинена вірусом Зіка | Вірусна інфекція Зіка |
| zh | 寨卡病毒疾病 | 寨卡病毒感染 |
| tr | Zika virüs hastalığı | Zika virüs enfeksiyonu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A92.5 | E | specific | validated |
| ICD-11 | 1D48 | E | specific | validated |
| MONDO | 0018661 | E | validated | |
| MeSH | D000071243 | E | validated | |
| UMLS | C0276289 | E | validated | |
| GARD | 12894 | E | validated | |
| MedDRA | 10078205 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163585Rare viral disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
| Annual incidence | 1-5 / 10 000 | 58.8 / 100 000 | Brazil | Value and class | Validated | World Health Organization 2016[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
34 annotations · validated 2020-03-04| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0040186 | Maculopapular exanthema | |
| HP:0000988 | Skin rash | |
| Frequent (79-30%) | ||
| HP:0002921 | Abnormality of the cerebrospinal fluid | |
| HP:0002829 | Arthralgia | |
| HP:0001369 | Arthritis | |
| HP:0000509 | Conjunctivitis | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0003496 | Increased circulating IgM level | |
| HP:0003326 | Myalgia | |
| HP:0000989 | Pruritus | |
| Occasional (29-5%) | ||
| HP:0001785 | Ankle swelling | |
| HP:0000969 | Edema | |
| HP:0012779 | Transient hearing impairment | |
| HP:0002013 | Vomiting | |
| HP:0001225 | Wrist swelling | |
| Very rare (<4-1%) | ||
| HP:0012795 | Abnormality of the optic disc | |
| HP:0030825 | Absent foveal reflex | |
| HP:0007131 | Acute demyelinating polyneuropathy | |
| HP:0000533 | Chorioretinal atrophy | |
| HP:0006906 | Congenital intracerebral calcification | |
| HP:0002383 | Infectious encephalitis | |
| HP:0001511 | Intrauterine growth retardation | |
| HP:0000612 | Iris coloboma | |
| HP:0001132 | Lens subluxation | |
| HP:0007401 | Macular atrophy | |
| HP:0001287 | Meningitis | |
| HP:0000252 | Microcephaly | |
| HP:0012486 | Myelitis | |
| HP:0007766 | Optic disc hypoplasia | |
| HP:0007814 | Retinal pigment epithelial mottling | |
| HP:0005268 | Spontaneous abortion | |
| HP:0001933 | Subcutaneous hemorrhage | |
| HP:0001873 | Thrombocytopenia | |
Run the differential on the 2 obligate / very frequent terms
Annotation source: 28457349[PMID]_27028561[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/448237
- This record as JSON: /data/d/448237.json