{"orpha":448237,"name":"Zika virus disease","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Zika virus infection"],"definition":"Zika virus disease is an emerging <i>Aedes</i> mosquito-born virus disease characterized by a clinical course that may be asymptomatic or mild with fever, conjunctivitis, muscle and joint pain, headache, exanthema, but may also be associated with severe neurological (meningitis, meningoencephalitis and myelitis) and auto-immune (Guillain-Barre syndrome) complications, as well as a potential increase of birth defects (microcephaly) if the infection occurs during pregnancy.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-448237/","orphanet_url":"https://www.orpha.net/en/disease/detail/448237","names":{"fr":{"name":"Maladie à virus Zika","synonyms":["Infection à virus Zika"],"definition":"Maladie émergente due à un virus transmis par le moustique <i>Aedes</i>, caractérisée par une évolution clinique qui peut être asymptomatique ou bénigne avec fièvre, conjonctivite, douleurs musculaires et articulaires, maux de tête et exanthème, mais qui peut aussi être associée à des complications neurologiques (méningite, méningo-encéphalite et myélite) et auto-immunes (syndrome de Guillain-Barré) sévères, ainsi qu'à une augmentation possible des malformations congénitales (microcéphalie) en cas d'infection pendant la grossesse."},"de":{"name":"Zikavirus-Infektion","synonyms":["Zika-Virus-Krankheit"]},"es":{"name":"Enfermedad por el virus de Zika","synonyms":["Infección por el virus de Zika"],"definition":"Es una enfermedad emergente transmitida por el mosquito <i>Aedes</i> portador del virus. Se caracteriza por un curso clínico que puede ser asintomático o leve acompañado de fiebre, conjuntivitis, dolor muscular y articular, cefalea y exantema. Sin embargo, también puede estar asociado a complicaciones neurológicas graves (meningitis, meningoencefalitis y mielitis) y autoinmunes (síndrome de Guillain-Barré), así como a un potencial aumento de defectos del desarrollo neurológico (microcefalia) si la infección se produce durante el embarazo."},"it":{"name":"Malattia del virus Zika","synonyms":["Infezione da virus Zika"],"definition":"La malatia da virus Zika è una nuova patologia virale trasmessa dalla zanzara Aedes. Il decorso clinico può essere asintomatico oppure lieve, ed è caratterizzato da febbre, congiuntivite, dolore muscolare e articolare, cefalea ed esantema, ma può anche associarsi a gravi complicanze neurologiche (meningite, meningoencefalite e mielite) e autoimmuni (sindrome di Guillain-Barré) e ad un aumento del rischio di difetti alla nascita (microcefalia), se la madre contrae l'infezione durante la gravidanza."},"nl":{"name":"Ziekte door zikavirus","synonyms":["Infectie door zikavirus"],"definition":"Zikavirusziekte is een opkomende virale ziekte die wordt overgedragen door muggen van het geslacht <i>Aedes</i>, en die gekarakteriseerd wordt door een asymptomatisch of mild klinisch verloop met koorts, bindvliesontsteking, spier- en gewrichtspijn, hoofdpijn en exantheem, maar die ook kan geassocieerd zijn met ernstige neurologische (meningitis, meningo-encefalitis en myelitis) en auto-immune (syndroom van Guillain-Barré) complicaties, en met een potentiële toename van geboortedefecten (microcefalie) wanneer de infectie voorkomt tijdens de zwangerschap."},"pt":{"name":"Doença do vírus Zika","synonyms":["Infecção virus Zika"]},"pl":{"name":"Choroba wywołana przez wirus Zika","synonyms":["Zakażenie wirusem Zika"]},"cs":{"name":"Onemocnění virem Zika","synonyms":["Infekce virem Zika","Zika"]},"uk":{"name":"Хвороба, спричинена вірусом Зіка","synonyms":["Вірусна інфекція Зіка"],"definition":"Zika virus disease is an emerging <i>Aedes</i> mosquito-born virus disease characterized by a clinical course that may be asymptomatic or mild with fever, conjunctivitis, muscle and joint pain, headache, exanthema, but may also be associated with severe neurological (meningitis, meningoencephalitis and myelitis) and auto-immune (Guillain-Barre syndrome) complications, as well as a potential increase of birth defects (microcephaly) if the infection occurs during pregnancy."},"zh":{"name":"寨卡病毒疾病","synonyms":["寨卡病毒感染"],"definition":"寨卡病毒病是一种新兴的伊蚊蚊子传播疾病，其特征是临床过程可能无症状或轻度，伴有发热，结膜炎，肌肉和关节疼痛，头痛，皮疹，但也可能合并严重的神经系统疾病（脑膜炎，脑膜脑炎和脊髓炎）和自身免疫性疾病（格林-巴利综合征）并发症。如果在怀孕期间发生感染，可能会导致出生缺陷（小头畸形）发生概率增加。"},"tr":{"name":"Zika virüs hastalığı","synonyms":["Zika virüs enfeksiyonu"]}},"xrefs":[{"source":"ICD-10","code":"A92.5","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D48","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1401438580"},{"source":"MONDO","code":"0018661","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D000071243","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0276289","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"12894","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10078205","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":58.8,"area":"Brazil","status":"Validated","source":"World Health Organization 2016[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-04","source":"28457349[PMID]_27028561[PMID]","terms":[{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002921","label":"Abnormality of the cerebrospinal fluid","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001785","label":"Ankle swelling","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012779","label":"Transient hearing impairment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001225","label":"Wrist swelling","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012795","label":"Abnormality of the optic disc","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030825","label":"Absent foveal reflex","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007131","label":"Acute demyelinating polyneuropathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000533","label":"Chorioretinal atrophy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0006906","label":"Congenital intracerebral calcification","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001511","label":"Intrauterine growth retardation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000612","label":"Iris coloboma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001132","label":"Lens subluxation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007401","label":"Macular atrophy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000252","label":"Microcephaly","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012486","label":"Myelitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007766","label":"Optic disc hypoplasia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007814","label":"Retinal pigment epithelial mottling","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001933","label":"Subcutaneous hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Very rare (<4-1%)","criteria":null}]}}