Placental insufficiency
Synonyms: Uteroplacental vascular insufficiency
- Type
- Clinical syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A rare obstetric disease characterized by inadequate blood flow to the placenta during pregnancy, resulting in a decrease in trans-placental transfer of oxygen and nutrients to the fetus, potentially leading to fetal growth retardation, distress, or death. Maternal risk factors include preeclampsia, gestational diabetes, and smoking, among others.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Placental insufficiency | Uteroplacental vascular insufficiency |
| fr | Insuffisance placentaire | Insuffisance placentaire vasculaire |
| de | Plazentainsuffizienz | Uteroplazentale vaskuläre Insuffizienz |
| es | Insuficiencia placentaria | Insuficiencia vascular uteroplacentaria |
| it | Insufficienza placentare | Insufficienza vascolare utero-placentare |
| nl | Placentale insufficiëntie | Placenta-insufficiëntie · Uteroplacentale vasculaire insufficiëntie |
| pt | Insuficiência placentar | |
| pl | Niewydolność łożyska | Niewydolność naczyń maciczno-łożyskowych |
| cs | Placentární insuficience | Uteroplacentární vaskulární insuficience |
| uk | Плацентарна недостатність | Матково-плацентарна судинна недостатність |
| zh | 胎盘功能不全 | 子宫胎盘血管功能不全 |
| tr | Plasental yetmezlik | Uteroplasental vasküler yetmezlik |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | O36.5 | NTBT | inclusion | validated |
| ICD-10 | P02.2 | NTBT | inclusion | validated |
| ICD-11 | JA8A.Y | NTBT | index | validated |
| MONDO | 0005919 | E | validated | |
| MeSH | D010927 | E | validated | |
| UMLS | C0032051 | E | validated | |
| MedDRA | 10035138 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163637Rare disorder related with pregnancy, childbirth and puerperium
rare gynecological and obstetric diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 33 / 100 000 | Worldwide | Value and class | Validated | European Medicines Agency 2015[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
20 annotations · validated 2024-03-15| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Obligate (100%) | ||
| HP:0100767 | Abnormality of the placenta | |
| Very frequent (99-80%) | ||
| HP:0011403 | Abnormal umbilical cord blood vessels | |
| HP:0012418 | Hypoxemia | |
| HP:0001511 | Intrauterine growth retardation | |
| HP:0003508 | Proportionate short stature | |
| HP:0001518 | Small for gestational age | |
| HP:0006266 | Small placenta | |
| Frequent (79-30%) | ||
| HP:0003613 | Antiphospholipid antibody positivity | |
| HP:0000717 | Autism | |
| HP:0000729 | Autistic behavior | |
| HP:0012759 | Neurodevelopmental abnormality | |
| HP:0002725 | Systemic lupus erythematosus | |
| Occasional (29-5%) | ||
| HP:0001627 | Abnormal heart morphology | |
| HP:0002088 | Abnormal lung morphology | |
| HP:0100021 | Cerebral palsy | |
| HP:0100601 | Eclampsia | |
| HP:0000855 | Insulin resistance | |
| HP:0008071 | Maternal hypertension | |
| HP:0100602 | Preeclampsia | |
| HP:0005268 | Spontaneous abortion | |
Run the differential on the 7 obligate / very frequent terms
Annotation source: 15383103[PMID]_26098843[PMID]_25485869[PMID]_23320863[PMID]_22521456[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/439167
- This record as JSON: /data/d/439167.json