{"orpha":439167,"name":"Placental insufficiency","type":"Clinical syndrome","group":"Disorder","status":"active","flags":[],"synonyms":["Uteroplacental vascular insufficiency"],"definition":"A rare obstetric disease characterized by inadequate blood flow to the placenta during pregnancy, resulting in a decrease in trans-placental transfer of oxygen and nutrients to the fetus, potentially leading to fetal growth retardation, distress, or death. Maternal risk factors include preeclampsia, gestational diabetes, and smoking, among others.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-439167/","orphanet_url":"https://www.orpha.net/en/disease/detail/439167","names":{"fr":{"name":"Insuffisance placentaire","synonyms":["Insuffisance placentaire vasculaire"],"definition":"Maladie obstétrique rare caractérisée par un flux sanguin insuffisant vers le placenta pendant la grossesse, à l'origine d'un approvisionnement réduit en oxygène et en nutriments du foetus, qui peut potentiellement entraîner un retard de croissance, une souffrance foetale ou le décès du foetus. Les facteurs de risque maternels sont, entre autres, pré-éclampsie, diabète gestationnel et tabagisme."},"de":{"name":"Plazentainsuffizienz","synonyms":["Uteroplazentale vaskuläre Insuffizienz"],"definition":"Eine seltene geburtshilfliche Erkrankung, die durch eine unzureichende Durchblutung der Plazenta während der Schwangerschaft gekennzeichnet ist und zu einer verminderten transplazentaren Versorgung des Fötus mit Sauerstoff und Nährstoffen führt, was in der Folge zu einer Wachstumsretardierung des Fötus, zu lebensbedrohlichen Zuständen oder sogar zum Tod führen kann. Zu den mütterlichen Risikofaktoren gehören Präeklampsie, Schwangerschaftsdiabetes und Rauchen."},"es":{"name":"Insuficiencia placentaria","synonyms":["Insuficiencia vascular uteroplacentaria"],"definition":"Es una enfermedad obstétrica poco frecuente caracterizada por un flujo sanguíneo inadecuado a la placenta durante el periodo de gestación, que da lugar a una disminución de la transferencia transplacentaria de oxígeno y nutrientes al feto, pudiendo provocar un retraso del crecimiento, sufrimiento o muerte fetal. Los factores de riesgo maternos son la preeclampsia, la diabetes gestacional y el tabaquismo, entre otros."},"it":{"name":"Insufficienza placentare","synonyms":["Insufficienza vascolare utero-placentare"],"definition":"Si tratta di una malattia rara, di interesse ostetrico, caratterizzata da un flusso di sangue inadeguato verso la placenta durante la gravidanza, con la conseguente riduzione del trasferimento transplacentare di ossigeno e sostanze nutritive al feto, che può causare ritardo della crescita, sofferenza o morte del feto. I fattori di rischio nella madre comprendono la preeclampsia, il diabete gestazionale e il fumo."},"nl":{"name":"Placentale insufficiëntie","synonyms":["Placenta-insufficiëntie","Uteroplacentale vasculaire insufficiëntie"],"definition":"Een zeldzame obstetrische aandoening, gekenmerkt door inadequate bloedstroom naar placenta tijdens de zwangerschap, wat resulteert in afname van transplacentale transfer van zuurstof en nutriënten naar de foetus, mogelijk met foetale groeiretardatie, nood of sterfte tot gevolg. Maternale risicofactoren zijn onder meer pre-eclampsie, zwangerschapsdiabetes, en roken."},"pt":{"name":"Insuficiência placentar"},"pl":{"name":"Niewydolność łożyska","synonyms":["Niewydolność naczyń maciczno-łożyskowych"]},"cs":{"name":"Placentární insuficience","synonyms":["Uteroplacentární vaskulární insuficience"]},"uk":{"name":"Плацентарна недостатність","synonyms":["Матково-плацентарна судинна недостатність"],"definition":"A rare obstetric disease characterized by inadequate blood flow to the placenta during pregnancy, resulting in a decrease in trans-placental transfer of oxygen and nutrients to the fetus, potentially leading to fetal growth retardation, distress, or death. Maternal risk factors include preeclampsia, gestational diabetes, and smoking, among others."},"zh":{"name":"胎盘功能不全","synonyms":["子宫胎盘血管功能不全"]},"tr":{"name":"Plasental yetmezlik","synonyms":["Uteroplasental vasküler yetmezlik"]}},"xrefs":[{"source":"ICD-10","code":"O36.5","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-10","code":"P02.2","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"JA8A.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"577097433"},{"source":"MONDO","code":"0005919","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D010927","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0032051","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10035138","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":96344,"name":"Rare gynecologic or obstetric disease"},"parents":[{"orpha":163637,"name":"Rare disorder related with pregnancy, childbirth and puerperium","classifications":[205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":33.0,"area":"Worldwide","status":"Validated","source":"European Medicines Agency 2015[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-03-15","source":"15383103[PMID]_26098843[PMID]_25485869[PMID]_23320863[PMID]_22521456[PMID]","terms":[{"hpo":"HP:0100767","label":"Abnormality of the placenta","frequency":"Obligate (100%)","criteria":null},{"hpo":"HP:0011403","label":"Abnormal umbilical cord blood vessels","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001511","label":"Intrauterine growth retardation","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003508","label":"Proportionate short stature","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001518","label":"Small for gestational age","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006266","label":"Small placenta","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003613","label":"Antiphospholipid antibody positivity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000717","label":"Autism","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000729","label":"Autistic behavior","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012759","label":"Neurodevelopmental abnormality","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002725","label":"Systemic lupus erythematosus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001627","label":"Abnormal heart morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002088","label":"Abnormal lung morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100021","label":"Cerebral palsy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100601","label":"Eclampsia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000855","label":"Insulin resistance","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008071","label":"Maternal hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100602","label":"Preeclampsia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Occasional (29-5%)","criteria":null}]}}