ORPHA:43116

Serotonin syndrome

Synonyms: Serotonergic syndrome · Serotonin storm · Serotonin toxicity · Serotonin toxidrome

Type: Disease
Group: Disorder
Inheritance: Not applicable
Age of onset: All ages
Status: active

A rare neurologic disease characterized by an excess of serotonin in the central nervous system, associated with the use of various agents, including selective serotonin reuptake inhibitors (SSRIs) and recreational stimulants.

Names in Orphadata languages

12 of 12 languages

Lang	Name	Synonyms
en	Serotonin syndrome	Serotonergic syndrome · Serotonin storm · Serotonin toxicity · Serotonin toxidrome
fr	Syndrome sérotoninergique
de	Serotonin-Syndrom
es	Síndrome serotoninérgico
it	Sindrome serotoninergica
nl	Serotoninesyndroom	Serotonerge syndroom · Serotonine-toxiciteit · Serotoninestorm · Serotoninetoxidroom
pt	Síndrome da serotonina	Síndrome serotoninérgico · Toxicidade da serotonina
pl	Zespół serotoninowy	Burza serotoninowa · Toksyczność serotoninowa · Zespół serotonergiczny
cs	Serotoninový syndrom	Serotonergický syndrom · Serotoninová toxicita · Serotoninový toxidrom · Serotoninová bouře
uk	Серотоніновий синдром	Серотонінергічний синдром · Серотоніновий шторм · Токсичність серотоніну · Серотоніновий токсикоз
zh	血清素综合征	血清素能综合症
tr	Serotonin sendromu	Serotonin fırtınası · Serotonin toksisitesi · Serotonin toksidromu · Serotonerjik sendrom

Definition in:

Cross-references

qualifier = Orphanet mapping relation

Source	Code	Qualifier	ICD relation	Validation
ICD-10	T43.1	NTBT	attributed	validated
ICD-11	8D85	NTBT	index	validated
MONDO	0018546	E		validated
MeSH	D020230	E		validated
UMLS	C0699828	E		validated
MedDRA	10040108	E		validated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

Classification

Preferential parent (Orphanet linearisation):

ORPHA:98006Rare neurologic disease

Parents in the classifications (1):

ORPHA:466658Rare disease with malignant hyperthermia
rare neurological diseases

No children.

Genes

0 direct

Orphanet records no gene directly on this code.

Prevalence and incidence

1 record

Type	Class	Value	Area	Qualification	Validation	Source
Point prevalence	Unknown	—	Worldwide	Class only	Validated	ORPHANET

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

HPO phenotypes

34 annotations · validated 2021-01-14

HPO	Term (as annotated by Orphanet)	Diagnostic
Very frequent (99-80%)
HP:0002270	Abnormality of the autonomic nervous system
Frequent (79-30%)
HP:0000739	Anxiety
HP:0001289	Confusion
HP:0002014	Diarrhea
HP:0100785	Insomnia
HP:0000737	Irritability
HP:0001268	Mental deterioration
HP:0001336	Myoclonus
HP:0002018	Nausea
HP:0000711	Restlessness
HP:0001649	Tachycardia
HP:0001337	Tremor
Occasional (29-5%)
HP:0000570	Abnormal saccadic eye movements
HP:0000713	Agitation
HP:0002169	Clonus
HP:0032044	Decreased vigilance
HP:0000975	Hyperhidrosis
HP:0001347	Hyperreflexia
HP:0000822	Hypertension
HP:0003128	Lactic acidosis
HP:0011499	Mydriasis
HP:0001250	Seizure
HP:0002789	Tachypnea
Very rare (<4-1%)
HP:0001919	Acute kidney injury
HP:0001259	Coma
HP:0031258	Delirium
HP:0005521	Disseminated intravascular coagulation
HP:0001945	Fever
HP:0000738	Hallucinations
HP:0001399	Hepatic failure
HP:0001276	Hypertonia
HP:0002615	Hypotension
HP:0003201	Rhabdomyolysis
HP:0002063	Rigidity

Run the differential on the 1 obligate / very frequent terms

Annotation source: 30243558[PMID]_30315014[PMID]_31075831[PMID]

Sources for this card

Orphanet page: orpha.net/en/disease/detail/43116
This record as JSON: /data/d/43116.json