{"orpha":43116,"name":"Serotonin syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Serotonergic syndrome","Serotonin storm","Serotonin toxicity","Serotonin toxidrome"],"definition":"A rare neurologic disease characterized by an excess of serotonin in the central nervous system, associated with the use of various agents, including selective serotonin reuptake inhibitors (SSRIs) and recreational stimulants.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-43116/","orphanet_url":"https://www.orpha.net/en/disease/detail/43116","names":{"fr":{"name":"Syndrome sérotoninergique","definition":"Maladie neurologique rare caractérisée par un excès de sérotonine dans le système nerveux central, associée à l'utilisation de divers agents, notamment les inhibiteurs sélectifs de la recapture de la sérotonine (ISRS) et les stimulants récréatifs."},"de":{"name":"Serotonin-Syndrom","definition":"Eine seltene neurologische Erkrankung, die durch einen Überschuss an Serotonin im zentralen Nervensystem gekennzeichnet ist und mit der Einnahme verschiedener Wirkstoffe in Verbindung gebracht wird, darunter selektive Serotonin-Wiederaufnahmehemmer (SSRI) und Stimulanzien für die Freizeit."},"es":{"name":"Síndrome serotoninérgico","definition":"Es una enfermedad neurológica poco frecuente caracterizada por un exceso de serotonina en el sistema nervioso central asociada al uso de diversos agentes farmacológicos, incluyendo los inhibidores selectivos de la recaptación de serotonina (ISRS) y los estimulantes de uso recreativo."},"it":{"name":"Sindrome serotoninergica"},"nl":{"name":"Serotoninesyndroom","synonyms":["Serotonerge syndroom","Serotonine-toxiciteit","Serotoninestorm","Serotoninetoxidroom"],"definition":"Een zeldzame neurologische aandoening, gekenmerkt door overmaat van serotonine in centraal zenuwstelsel, geassocieerd met het gebruik van verschillende agentia, waaronder selectieve serotonineheropnameremmers (SSRI's) en recreatieve drugs."},"pt":{"name":"Síndrome da serotonina","synonyms":["Síndrome serotoninérgico","Toxicidade da serotonina"],"definition":"Doença neurológica rara caracterizada por um excesso de serotonina no sistema nervoso central, associada ao uso de vários agentes, incluindo inibidores seletivos de recaptação de serotonina (ISRS) e estimulantes recreativos."},"pl":{"name":"Zespół serotoninowy","synonyms":["Burza serotoninowa","Toksyczność serotoninowa","Zespół serotonergiczny"]},"cs":{"name":"Serotoninový syndrom","synonyms":["Serotonergický syndrom","Serotoninová toxicita","Serotoninový toxidrom","Serotoninová bouře"]},"uk":{"name":"Серотоніновий синдром","synonyms":["Серотонінергічний синдром","Серотоніновий шторм","Токсичність серотоніну","Серотоніновий токсикоз"],"definition":"A rare neurologic disease characterized by an excess of serotonin in the central nervous system, associated with the use of various agents, including selective serotonin reuptake inhibitors (SSRIs) and recreational stimulants."},"zh":{"name":"血清素综合征","synonyms":["血清素能综合症"]},"tr":{"name":"Serotonin sendromu","synonyms":["Serotonin fırtınası","Serotonin toksisitesi","Serotonin toksidromu","Serotonerjik sendrom"]}},"xrefs":[{"source":"ICD-10","code":"T43.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8D85","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"678764364"},{"source":"MONDO","code":"0018546","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D020230","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0699828","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10040108","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":466658,"name":"Rare disease with malignant hyperthermia","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-01-14","source":"30243558[PMID]_30315014[PMID]_31075831[PMID]","terms":[{"hpo":"HP:0002270","label":"Abnormality of the autonomic nervous system","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000739","label":"Anxiety","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100785","label":"Insomnia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001268","label":"Mental deterioration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001336","label":"Myoclonus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000711","label":"Restlessness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000570","label":"Abnormal saccadic eye movements","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000713","label":"Agitation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002169","label":"Clonus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032044","label":"Decreased vigilance","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001347","label":"Hyperreflexia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003128","label":"Lactic acidosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031258","label":"Delirium","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000738","label":"Hallucinations","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001399","label":"Hepatic failure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001276","label":"Hypertonia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002063","label":"Rigidity","frequency":"Very rare (<4-1%)","criteria":null}]}}