Pulmonary non-tuberculous mycobacterial infection
Synonyms: Non-tuberculous mycobacterial lung disease
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare bacterial infectious disease caused by non-tuberculous mycobacteria (including <i>Mycobacterium avium</i> complex, <i>Mycobacterium kansasii</i>, or <i>Mycobacterium xenopi</i>, among others), characterized by chronic pulmonary disease with symptoms like chronic cough (with or without sputum production), chest pain, and weight loss. Predisposing factors are preexisting lung conditions, neoplasms, immunosuppression, or thoracic skeletal abnormalities.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Pulmonary non-tuberculous mycobacterial infection | Non-tuberculous mycobacterial lung disease |
| fr | Infection pulmonaire à mycobactéries atypiques | Infection pulmonaire à mycobactéries non-tuberculeuses · Maladie pulmonaire à mycobactéries atypiques |
| de | Pulmonale nicht-tuberkulöse mykobakterielle Infektion | NTM-Lungeninfektion · Pulmonale NTM-Infektion · Lungenkrankheit, mykobakterielle nicht-tuberkulöse · MOTT-Lungeninfektion |
| es | Infección pulmonar por micobacterias no tuberculosas | Enfermedad pulmonar micobacteriana no tuberculosa |
| it | Infezione polmonare micobatterica non tubercolare | Malattia polmonare micobatterica non tubercolare |
| nl | Pulmonale niet-tuberculeuze mycobacteriële infectie | Niet-tuberculeuze mycobacteriële longziekte |
| pt | Infeção pulmonar micobacteriana não-tuberculose | |
| pl | Niegruźlicza mykobakteryjna infekcja płuc | Niegruźlicza mykobakteryjna choroba płuc |
| cs | Mykobakteriální plicní infekce, netuberkulózní | Netuberkulózní mykobakteriální onemocnění plic |
| uk | Легенева нетуберкульозна мікобактеріальна інфекція | Нетуберкульозні мікобактеріальні захворювання легень |
| zh | 肺非结核分枝杆菌感染 | 非结节性分枝杆菌性肺病 |
| tr | Pulmoner tüberküloz dışı mikobakteriyel enfeksiyon | Tüberküloz dışı mikobakteriyel akciğer hastalığı |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A31.0 | E | specific | validated |
| ICD-11 | 1B21.0 | E | specific | validated |
| MONDO | 0018469 | E | validated | |
| UMLS | C3472679 | E | validated | |
| GARD | 12829 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:163582Rare bacterial infectious disease
rare infectious diseases - ORPHA:101944Rare pulmonary disease
rare respiratory diseases
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:314946OBSOLETE: Mycobacterium xenopi infection referred to · inactive
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 6 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2014[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
24 annotations · validated 2026-06-10| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012735 | Cough | |
| HP:0032261 | Nontuberculous mycobacterial pulmonary infection | |
| HP:0031245 | Productive cough | |
| Frequent (79-30%) | ||
| HP:0025406 | Asthenia | |
| HP:0002110 | Bronchiectasis | |
| HP:0031352 | Chest tightness | |
| HP:0034315 | Chronic cough | |
| HP:0012378 | Fatigue | |
| HP:0002105 | Hemoptysis | |
| HP:0002721 | Immunodeficiency | |
| HP:0033709 | Increased sputum production | |
| HP:0430108 | Positive Mycobacterium avium sputum culture | |
| HP:0033655 | Pulmonary cavity | |
| HP:0033608 | Pulmonary nodule | |
| HP:0031457 | Pulmonary opacity | |
| Occasional (29-5%) | ||
| HP:0100749 | Chest pain | |
| HP:0006510 | Chronic pulmonary obstruction | |
| HP:0002094 | Dyspnea | |
| HP:0001945 | Fever | |
| HP:0100721 | Mediastinal lymphadenopathy | |
| HP:0030166 | Night sweats | |
| HP:0002202 | Pleural effusion | |
| HP:0001824 | Weight loss | |
| Very rare (<4-1%) | ||
| HP:0002107 | Pneumothorax | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 29332619[PMID]_31477038[PMID]_31101082[PMID]_37424783[PMID]_36668957[PMID]_35090639[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/411703
- This record as JSON: /data/d/411703.json