{"orpha":411703,"name":"Pulmonary non-tuberculous mycobacterial infection","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Non-tuberculous mycobacterial lung disease"],"definition":"A rare bacterial infectious disease caused by non-tuberculous mycobacteria (including <i>Mycobacterium avium</i> complex, <i>Mycobacterium kansasii</i>, or <i>Mycobacterium xenopi</i>, among others), characterized by chronic pulmonary disease with symptoms like chronic cough (with or without sputum production), chest pain, and weight loss. Predisposing factors are preexisting lung conditions, neoplasms, immunosuppression, or thoracic skeletal abnormalities.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-411703/","orphanet_url":"https://www.orpha.net/en/disease/detail/411703","names":{"fr":{"name":"Infection pulmonaire à mycobactéries atypiques","synonyms":["Infection pulmonaire à mycobactéries non-tuberculeuses","Maladie pulmonaire à mycobactéries atypiques"],"definition":"Maladie infectieuse bactérienne rare causée par des mycobactéries non tuberculeuses (à savoir, <i>complexe Mycobacterium avium</i>, <i>Mycobacterium kansasii</i> ou <i>Mycobacterium xenopi</i>), caractérisée par une maladie pulmonaire chronique dont les signes cliniques sont une toux chronique (avec ou sans glaires), des douleurs thoraciques et une perte de poids. Les facteurs de prédisposition sont les maladies pulmonaires préexistantes, les tumeurs, l'immunosuppression ou les malformations de la cage thoracique."},"de":{"name":"Pulmonale nicht-tuberkulöse mykobakterielle Infektion","synonyms":["NTM-Lungeninfektion","Pulmonale NTM-Infektion","Lungenkrankheit, mykobakterielle nicht-tuberkulöse","MOTT-Lungeninfektion"],"definition":"Eine seltene bakterielle Infektionskrankheit, die durch nicht-tuberkulöse Mykobakterien (u.a. <i>Mycobacterium avium</i> complex, <i>Mycobacterium kansasii</i> oder <i>Mycobacterium xenopi</i>) verursacht wird, gekennzeichnet durch eine chronische Lungenerkrankung mit Symptomen wie chronischer Husten (mit oder ohne Sputumproduktion), Brustschmerzen und Gewichtsverlust. Prädisponierende Faktoren sind vorbestehende Lungenerkrankungen, Neoplasien, Immunsuppression oder skelettalen Anomalien des Brustkorbes."},"es":{"name":"Infección pulmonar por micobacterias no tuberculosas","synonyms":["Enfermedad pulmonar micobacteriana no tuberculosa"],"definition":"Es una enfermedad infecciosa bacteriana poco frecuente causada por micobacterias no tuberculosas (incluyendo el conjunto <i>Mycobacterium avium</i>, <i>Mycobacterium kansasii</i> o <i>Mycobacterium xenopi</i>, entre otros), caracterizada por una enfermedad pulmonar crónica con síntomas tales como tos crónica (con o sin producción de esputo), dolor torácico y pérdida de peso. Los factores de predisposición son las afecciones pulmonares preexistentes, las neoplasias, la inmunosupresión o las anomalías esqueléticas torácicas."},"it":{"name":"Infezione polmonare micobatterica non tubercolare","synonyms":["Malattia polmonare micobatterica non tubercolare"],"definition":"Si tratta di una malattia infettiva batterica rara, causata da micobatteri non tubercolari (tra i quali il complesso <i>Mycobacterium avium</i>, il <i>Mycobacterium kansasii</i> e il <i>Mycobacterium xenopi</i>), caratterizzata da pneumopatia cronica che si manifesta con tosse cronica (secca o produttiva), dolore toracico e perdita di peso. I fattori predisponenti sono le pneumopatie preesistenti, le neoplasie, l'immunosoppressione e le anomalie scheletriche del torace."},"nl":{"name":"Pulmonale niet-tuberculeuze mycobacteriële infectie","synonyms":["Niet-tuberculeuze mycobacteriële longziekte"],"definition":"Een zeldzame, bacteriële infectieziekte, veroorzaakt door niet-tuberculeuze mycobacteriën (onder meer <i>Mycobacterium avium</i>-complex, <i>Mycobacterium kansasii</i>, of <i>Mycobacterium xenopi</i>), en gekarakteriseerd door chronische longziekte met symptomen als chronische hoest (met of zonder sputumproductie), pijn op borst, en gewichtsverlies. Predispositiefactoren zijn reeds aanwezige longaandoeningen, neoplasmata, immuunsuppressie, of thoracale skeletanomalieën."},"pt":{"name":"Infeção pulmonar micobacteriana não-tuberculose"},"pl":{"name":"Niegruźlicza mykobakteryjna infekcja płuc","synonyms":["Niegruźlicza mykobakteryjna choroba płuc"]},"cs":{"name":"Mykobakteriální plicní infekce, netuberkulózní","synonyms":["Netuberkulózní mykobakteriální onemocnění plic"]},"uk":{"name":"Легенева нетуберкульозна мікобактеріальна інфекція","synonyms":["Нетуберкульозні мікобактеріальні захворювання легень"],"definition":"A rare bacterial infectious disease caused by non-tuberculous mycobacteria (including <i>Mycobacterium avium</i> complex, <i>Mycobacterium kansasii</i>, or <i>Mycobacterium xenopi</i>, among others), characterized by chronic pulmonary disease with symptoms like chronic cough (with or without sputum production), chest pain, and weight loss. Predisposing factors are preexisting lung conditions, neoplasms, immunosuppression, or thoracic skeletal abnormalities."},"zh":{"name":"肺非结核分枝杆菌感染","synonyms":["非结节性分枝杆菌性肺病"],"definition":"一种由非结核分枝杆菌引起的罕见细菌感染性疾病（包括鸟分枝杆菌复合物，堪萨斯分枝杆菌或异种分枝杆菌等），临床表现为慢性肺部疾病引起的症状包括慢性咳嗽（有或没有痰产生），胸痛和体重减轻。诱发因素包括预先存在的肺部疾病，肿瘤，免疫抑制或胸廓骨骼异常。"},"tr":{"name":"Pulmoner tüberküloz dışı mikobakteriyel enfeksiyon","synonyms":["Tüberküloz dışı mikobakteriyel akciğer hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"A31.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1B21.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1798822437"},{"source":"MONDO","code":"0018469","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C3472679","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"12829","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":314946,"name":"OBSOLETE: Mycobacterium xenopi infection","status":"inactive"}],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]},{"orpha":101944,"name":"Rare pulmonary disease","classifications":[184]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":6.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2014[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2026-06-10","source":"29332619[PMID]_31477038[PMID]_31101082[PMID]_37424783[PMID]_36668957[PMID]_35090639[PMID]","terms":[{"hpo":"HP:0012735","label":"Cough","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0032261","label":"Nontuberculous mycobacterial pulmonary infection","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0031245","label":"Productive cough","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025406","label":"Asthenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002110","label":"Bronchiectasis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031352","label":"Chest tightness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0034315","label":"Chronic cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0033709","label":"Increased sputum production","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0430108","label":"Positive Mycobacterium avium sputum culture","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0033655","label":"Pulmonary cavity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0033608","label":"Pulmonary nodule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031457","label":"Pulmonary opacity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006510","label":"Chronic pulmonary obstruction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100721","label":"Mediastinal lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030166","label":"Night sweats","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002107","label":"Pneumothorax","frequency":"Very rare (<4-1%)","criteria":null}]}}