Histoplasmosis
Synonyms: Darling disease
- Type
- Disease
- Group
- Disorder
- Status
- active
A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of <i>Histoplasma capsulatum</i>. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons, the infection usually takes a self-limiting and asymptomatic or relatively mild, flu-like course. In immunocompromised patients, it can become progressive and disseminated, involving multiple organs and presenting with fever, pneumonia, hepatosplenomegaly, skin infiltrates, and endocarditis, among others.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Histoplasmosis | Darling disease |
| fr | Histoplasmose | Maladie de Darling |
| de | Histoplasmose | Darling-Krankheit |
| es | Histoplasmosis | Enfermedad de Darling |
| it | Istoplasmosi | Malattia di Darling |
| nl | Histoplasmose | Ziekte van Darling |
| pt | Histoplasmose | |
| pl | Histoplazmoza | Choroba Darlinga |
| cs | Histoplazmóza | Darlingova nemoc |
| uk | Гістоплазмоз | Хвороба коханої |
| zh | 组织胞浆菌病 | 荚膜组织胞浆菌病 |
| tr | Histoplazmoz | Darling hastalığı |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B39.0 | BTNT | specific | validated |
| ICD-10 | B39.1 | BTNT | specific | validated |
| ICD-10 | B39.2 | BTNT | specific | validated |
| ICD-10 | B39.3 | BTNT | specific | validated |
| ICD-10 | B39.4 | BTNT | specific | validated |
| ICD-10 | B39.5 | BTNT | specific | validated |
| ICD-10 | B39.9 | BTNT | specific | validated |
| ICD-11 | 1F2A | E | specific | validated |
| MONDO | 0018312 | E | validated | |
| MeSH | D006660 | E | validated | |
| UMLS | C0019655 | E | validated | |
| MedDRA | 10020141 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163591Rare mycosis
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/390
- This record as JSON: /data/d/390.json