{"orpha":390,"name":"Histoplasmosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Darling disease"],"definition":"A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of <i>Histoplasma capsulatum</i>. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons, the infection usually takes a self-limiting and asymptomatic or relatively mild, flu-like course. In immunocompromised patients, it can become progressive and disseminated, involving multiple organs and presenting with fever, pneumonia, hepatosplenomegaly, skin infiltrates, and endocarditis, among others.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-390/","orphanet_url":"https://www.orpha.net/en/disease/detail/390","names":{"fr":{"name":"Histoplasmose","synonyms":["Maladie de Darling"],"definition":"Mycose rare caractérisée par une inflammation granulomateuse principalement du poumon après inhalation de spores de <i>Histoplasma capsulatum</i>. La sévérité de l'évolution clinique de la maladie dépend de l'état immunitaire de l'individu et de la taille de l'inoculum. Chez les personnes immunocompétentes, l'infection évolue généralement de manière autolimitée et asymptomatique ou relativement légère, semblable à une grippe. Chez les patients immunodéprimés, elle peut devenir progressive et disséminée, touchant de multiples organes et se manifestant, entre autres, par de la fièvre, une pneumonie, une hépatosplénomégalie, des infiltrats cutanés et une endocardite."},"de":{"name":"Histoplasmose","synonyms":["Darling-Krankheit"],"definition":"Eine seltene Mykose, die durch eine granulomatöse Entzündung hauptsächlich der Lunge nach Inhalation von Sporen von <i>Histoplasma capsulatum</i> gekennzeichnet ist. Der Schweregrad der klinischen Erkrankung hängt vom Immunstatus der Person und der Größe des Inokulums ab. Bei immunkompetenten Personen nimmt die Infektion in der Regel einen selbstlimitierenden und asymptomatischen oder relativ milden, grippeähnlichen Verlauf. Bei immungeschwächten Patienten kann die Infektion progressiv und disseminiert verlaufen, mehrere Organe befallen und u. a. mit Fieber, Lungenentzündung, Hepatosplenomegalie, Hautinfiltraten und Endokarditis einhergehen."},"es":{"name":"Histoplasmosis","synonyms":["Enfermedad de Darling"],"definition":"Es una micosis poco frecuente caracterizada por una inflamación granulomatosa principalmente pulmonar tras la inhalación de esporas de <i>Histoplasma capsulatum</i>. La gravedad clínica de la enfermedad depende del estado inmunológico del individuo y del tamaño del inóculo. En personas inmunocompetentes, la infección suele presentar un curso autolimitado y asintomático o relativamente leve, similar a una gripe. En pacientes inmunocomprometidos, se puede tornar progresiva y diseminada, afectando a múltiples órganos y presentándose con fiebre, neumonía, hepatoesplenomegalia, infiltrados cutáneos y endocarditis, entre otros."},"it":{"name":"Istoplasmosi","synonyms":["Malattia di Darling"],"definition":"Si tratta di una micosi rara, caratterizzata da un'infiammazione granulomatosa che interessa soprattutto i polmoni, causata dall'inalazione delle spore di <i>Histoplasma capsulatum</i>. La gravità della malattia dipende dallo stato immunitario del paziente e dalle dimensioni dell'inoculo. Nei soggetti immunocompetenti, di solito l'infezione ha un decorso simil-influenzale autolimitante e sintomatico o relativamente lieve. Nei pazienti immunocompromessi, la malattia può progredire e diffondersi in altri organi, in associazione con la febbre, la polmonite, l'epatosplenomegalia, gli infiltrati cutanei e l'endocardite."},"nl":{"name":"Histoplasmose","synonyms":["Ziekte van Darling"],"definition":"Een zeldzame mycose, gekarakteriseerd door granulomateuze inflammatie van vooral long na inademing van sporen van <i>Histoplasma capsulatum</i>. De ernst van de klinische ziekte hangt af van de immuunstatus van het individu en het aantal kiemen. Bij immunocompetente personen heeft de infectie meestal een zelfbeperkend en asymptomatisch of relatief mild, griepachtig verloop. Bij immuungecompromitteerde patiënten kan het progressief en verspreid worden, met betrokkenheid van meerdere organen en een presentatie met onder meer koorts, pneumonie, hepatosplenomegalie, infiltraten in huid, en endocarditis."},"pt":{"name":"Histoplasmose"},"pl":{"name":"Histoplazmoza","synonyms":["Choroba Darlinga"]},"cs":{"name":"Histoplazmóza","synonyms":["Darlingova nemoc"]},"uk":{"name":"Гістоплазмоз","synonyms":["Хвороба коханої"],"definition":"A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of <i>Histoplasma capsulatum</i>. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons, the infection usually takes a self-limiting and asymptomatic or relatively mild, flu-like course. In immunocompromised patients, it can become progressive and disseminated, involving multiple organs and presenting with fever, pneumonia, hepatosplenomegaly, skin infiltrates, and endocarditis, among others."},"zh":{"name":"组织胞浆菌病","synonyms":["荚膜组织胞浆菌病"]},"tr":{"name":"Histoplazmoz","synonyms":["Darling hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"B39.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B39.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B39.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B39.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B39.4","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B39.5","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B39.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F2A","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1303003466"},{"source":"MONDO","code":"0018312","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D006660","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0019655","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10020141","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163591,"name":"Rare mycosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}