raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:353253

Burning mouth syndrome

Synonyms: BMS · Oral dysesthesia · Orodynia · Stomatodynia · Stomatopyrosis

Type
Disease
Group
Disorder
Inheritance
Unknown
Age of onset
Adult
Status
active

A rare neurologic disease characterized by an unremitting bilateral symmetrical burning sensation of the oral mucosa without clinical evidence of causative lesions. It most frequently occurs in postmenopausal women and typically affects the tongue, less often the palate, lips, or buccal mucosa. It is often associated with dysgeusia and xerostomia.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enBurning mouth syndromeBMS · Oral dysesthesia · Orodynia · Stomatodynia · Stomatopyrosis
frParesthésies buccales médicalement inexpliquéesBMS · PBMI · PBP · Paresthésies buccales psychogènes · Stomatodynies · Syndrome de la bouche en feu
deZungen- und SchleimhautbrennenBMS · Burning-Mouth-Syndrom · Orale Dysästhesie · Orolinguale Dysästhesie · Stomatodynie
esSíndrome de boca ardienteBMS · Disestesia oral · Estomatodinia · Estomatopirosis · Orodinia
itSindrome della bocca urenteBMS · Disestesia orale · Glossodinia · Glossopirosi · Orodinia · Stomatodinia · Stomatopirosi
nlSyndroom van mondbrandenStomatodynie · Stomatopyrose · BMS · Brandende mond-syndroom · Orale dysesthesie · Orodynie
ptSíndrome da boca queimada
plZespół piekących ustBMS · Orodynia · Stomatodynia
csBurning mouth syndromBMS · Orodynia · Stomatodynia · Stomatopyrosis · Oral dysesthesia · Orodynie · Stomatodynie · Stomatopyróza · Ústní dysestezie
ukСиндром печіння в ротіBMS · Оральна дизестезія · Ородинія · Стоматодинія · Стоматопіроз
zh灼口综合征口腔感觉障碍
trYanan ağız sendromuBMS · Orodini · Stomatodini · Stomatopiroz · Oral disestezi

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10K14.6BTNTattributedvalidated
ICD-11DA0F.0Especificvalidated
MONDO0006687Evalidated
MeSHD002054Evalidated
UMLSC0006430Evalidated
GARD5974Evalidated
MedDRA10068065Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

2 records
TypeClassValueAreaQualificationValidationSource
Point prevalenceUnknown—WorldwideClass onlyValidatedORPHANET_10478959[PMID]
Point prevalenceUnknown—EuropeClass onlyValidatedORPHANET_10478959[PMID]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

17 annotations · validated 2021-05-11
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0032143Burning mouth
Frequent (79-30%)
HP:0000223Abnormality of taste sensation
HP:0000739Anxiety
HP:0000716Depression
HP:0031249Parageusia
Occasional (29-5%)
HP:0010824Abnormal fifth cranial nerve morphology
HP:0007377Abnormality of somatosensory evoked potentials
HP:0000168Abnormality of the gingiva
HP:0012534Dysesthesia
HP:0000712Emotional lability
HP:0002315Headache
HP:0010829Impaired temperature sensition
HP:0002360Sleep abnormality
HP:0010298Smooth tongue
HP:0031042Strawberry tongue
HP:0030811Tongue pain
HP:0000217Xerostomia

Run the differential on the 1 obligate / very frequent terms

Annotation source: 29257770[PMID]_30603879[PMID]_32352482[PMID]_27207008[PMID]

7

Sources for this card