{"orpha":353253,"name":"Burning mouth syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["BMS","Oral dysesthesia","Orodynia","Stomatodynia","Stomatopyrosis"],"definition":"A rare neurologic disease characterized by an unremitting bilateral symmetrical burning sensation of the oral mucosa without clinical evidence of causative lesions. It most frequently occurs in postmenopausal women and typically affects the tongue, less often the palate, lips, or buccal mucosa. It is often associated with dysgeusia and xerostomia.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-353253/","orphanet_url":"https://www.orpha.net/en/disease/detail/353253","names":{"fr":{"name":"Paresthésies buccales médicalement inexpliquées","synonyms":["BMS","PBMI","PBP","Paresthésies buccales psychogènes","Stomatodynies","Syndrome de la bouche en feu"],"definition":"Maladie neurologique rare caractérisée par une sensation de brûlure bilatérale symétrique et continuelle de la muqueuse buccale, sans qu'une lésion organique ne puisse être objectivée. Elle survient le plus souvent chez les femmes ménopausées et affecte généralement la langue, les lèvres, la muqueuse buccale et moins souvent le palais. Elle est souvent associée à une dysgueusie et à une xérostomie."},"de":{"name":"Zungen- und Schleimhautbrennen","synonyms":["BMS","Burning-Mouth-Syndrom","Orale Dysästhesie","Orolinguale Dysästhesie","Stomatodynie"],"definition":"Eine seltene neurologische Erkrankung, die durch ein unablässiges beidseitiges symmetrisches Brennen der Mundschleimhaut gekennzeichnet ist, ohne dass klinische Hinweise auf ursächliche Läsionen vorliegen. Sie tritt am häufigsten bei postmenopausalen Frauen auf und betrifft typischerweise die Zunge, seltener den Gaumen, die Lippen oder die Wangenschleimhaut. Sie geht häufig mit Dysgeusie und Xerostomie einher."},"es":{"name":"Síndrome de boca ardiente","synonyms":["BMS","Disestesia oral","Estomatodinia","Estomatopirosis","Orodinia"],"definition":"Es una enfermedad neurológica poco frecuente caracterizada por una sensación de ardor simétrica bilateral constante de la mucosa oral sin evidencia clínica de lesiones causales. Ocurre con mayor frecuencia en mujeres posmenopáusicas y por lo general afecta a la lengua y, con menor frecuencia, al paladar, los labios o la mucosa oral. Se asocia a menudo con disgeusia y xerostomía."},"it":{"name":"Sindrome della bocca urente","synonyms":["BMS","Disestesia orale","Glossodinia","Glossopirosi","Orodinia","Stomatodinia","Stomatopirosi"],"definition":"Si tratta di una malattia neurologica rara, caratterizzata dalla persistente sensazione di bruciore della mucosa orale, bilaterale e simmetrica, in assenza di lesioni. Colpisce per lo più le donne in menopausa; di solito interessa la lingua e, più raramente, il palato, le labbra e la mucosa orale. Spesso si associa alla disgeusia e alla xerostomia."},"nl":{"name":"Syndroom van mondbranden","synonyms":["Stomatodynie","Stomatopyrose","BMS","Brandende mond-syndroom","Orale dysesthesie","Orodynie"],"definition":"Een zeldzame neurologische aandoening, gekarakteriseerd door een niet-remitterende bilaterale symmetrische brandende sensatie van wangslijmvlies zonder klinisch bewijs van causale laesies. De aandoening komt het vaakst voor bij postmenopauzale vrouwen en treft doorgaans tong, en minder vaak verhemelte, lippen of mondslijmvlies. Vaak is er associatie met dysgeusie en xerostomie."},"pt":{"name":"Síndrome da boca queimada"},"pl":{"name":"Zespół piekących ust","synonyms":["BMS","Orodynia","Stomatodynia"]},"cs":{"name":"Burning mouth syndrom","synonyms":["BMS","Orodynia","Stomatodynia","Stomatopyrosis","Oral dysesthesia","Orodynie","Stomatodynie","Stomatopyróza","Ústní dysestezie"]},"uk":{"name":"Синдром печіння в роті","synonyms":["BMS","Оральна дизестезія","Ородинія","Стоматодинія","Стоматопіроз"],"definition":"A rare neurologic disease characterized by an unremitting bilateral symmetrical burning sensation of the oral mucosa without clinical evidence of causative lesions. It most frequently occurs in postmenopausal women and typically affects the tongue, less often the palate, lips, or buccal mucosa. It is often associated with dysgeusia and xerostomia."},"zh":{"name":"灼口综合征","synonyms":["口腔感觉障碍"],"definition":"本病是一种罕见的神经系统疾病，其特征是口腔粘膜有持续的双侧对称烧灼感，没有临床证据证实的致病性损害。本病最常发生在绝经后妇女身上，通常影响舌头，较少发生在腭部、嘴唇或颊部粘膜。本病常与口臭和口干症有关。"},"tr":{"name":"Yanan ağız sendromu","synonyms":["BMS","Orodini","Stomatodini","Stomatopiroz","Oral disestezi"]}},"xrefs":[{"source":"ICD-10","code":"K14.6","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"DA0F.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"618998878"},{"source":"MONDO","code":"0006687","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D002054","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0006430","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5974","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10068065","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":98022,"name":"Rare headache","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_10478959[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Validated","source":"ORPHANET_10478959[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-05-11","source":"29257770[PMID]_30603879[PMID]_32352482[PMID]_27207008[PMID]","terms":[{"hpo":"HP:0032143","label":"Burning mouth","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000223","label":"Abnormality of taste sensation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000739","label":"Anxiety","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031249","label":"Parageusia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010824","label":"Abnormal fifth cranial nerve morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007377","label":"Abnormality of somatosensory evoked potentials","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000168","label":"Abnormality of the gingiva","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012534","label":"Dysesthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000712","label":"Emotional lability","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0010829","label":"Impaired temperature sensition","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002360","label":"Sleep abnormality","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0010298","label":"Smooth tongue","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031042","label":"Strawberry tongue","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030811","label":"Tongue pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000217","label":"Xerostomia","frequency":"Occasional (29-5%)","criteria":null}]}}