American trypanosomiasis
Synonyms: Chagas disease
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A tropical disease mainly found in latin America and transmitted by triatomine insects (mostly <i>Triatoma infestans</i> and <i>Rhodnius prolixus</i> and <i>Panstrongylus megistus</i>) harboring the hemoflagellate protozoan parasite <i>Trypanosoma cruzi</i>. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | American trypanosomiasis | Chagas disease |
| fr | Trypanosomiase américaine | Maladie de Chagas · Trypanosomose américaine |
| de | Amerikanische Trypanosomiasis | Chagas-Krankheit |
| es | Tripanosomiasis americana | Enfermedad de Chagas |
| it | Tripanosomiasi americana | Malattia di Chagas |
| nl | Amerikaanse trypanosomiase | Ziekte van Chagas |
| pt | Tripanossomíase americana | Doença de Chagas |
| pl | Trypanosomoza amerykańska | Choroba Chagasa |
| cs | Americká trypanozomiáza | Chagasova nemoc |
| uk | Американський трипаносомоз | Хвороба Шагаса |
| zh | 美洲锥虫病 | Chagas病 |
| tr | Amerikan tripanozomiyazı | Chagas hastalığı |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B57.0 | BTNT | specific | validated |
| ICD-10 | B57.1 | BTNT | specific | validated |
| ICD-10 | B57.2 | BTNT | specific | validated |
| ICD-10 | B57.3 | BTNT | specific | validated |
| ICD-10 | B57.4 | BTNT | specific | validated |
| ICD-10 | B57.5 | BTNT | specific | validated |
| ICD-11 | 1F53 | E | specific | validated |
| ICD-11 | 1F53.1 | BTNT | specific | validated |
| ICD-11 | 1F53.2 | BTNT | specific | validated |
| ICD-11 | 1F53.3 | BTNT | specific | validated |
| ICD-11 | 1F53.4 | BTNT | specific | validated |
| MONDO | 0001444 | E | validated | |
| MeSH | D014355 | E | validated | |
| UMLS | C0041234 | E | validated | |
| MedDRA | 10001935 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163588Rare parasitic disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
11 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | — | Europe | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | 1-9 / 1 000 000 | — | France | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | <1 / 1 000 000 | — | Germany | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | 1-9 / 1 000 000 | — | Italy | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | <1 / 1 000 000 | — | Netherlands | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | <1 / 1 000 000 | — | Portugal | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | 1-9 / 100 000 | — | Spain | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | 1-9 / 100 000 | — | Switzerland | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | <1 / 1 000 000 | — | United Kingdom | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | 1-9 / 1 000 000 | — | Belgium | Class only | Not yet validated | 21944556[PMID] |
| Point prevalence | 6-9 / 10 000 | 95 / 100 000 | United States | Value and class | Validated | 19640226[PMID]_Center for Diseases Control and Prevention [OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
27 annotations · validated 2017-02-14| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0011675 | Arrhythmia | |
| HP:0030057 | Autoimmune antibody positivity | |
| HP:0001638 | Cardiomyopathy | |
| HP:0012735 | Cough | |
| HP:0002014 | Diarrhea | |
| HP:0002094 | Dyspnea | |
| HP:0000969 | Edema | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0002240 | Hepatomegaly | |
| HP:0011355 | Localized skin lesion | |
| HP:0002716 | Lymphadenopathy | |
| HP:0003326 | Myalgia | |
| HP:0012819 | Myocarditis | |
| HP:0000980 | Pallor | |
| HP:0100539 | Periorbital edema | |
| HP:0000988 | Skin rash | |
| HP:0001744 | Splenomegaly | |
| HP:0001907 | Thromboembolism | |
| Occasional (29-5%) | ||
| HP:0012700 | Abnormal large intestine physiology | |
| HP:0002571 | Achalasia | |
| HP:0002251 | Aganglionic megacolon | |
| HP:0001635 | Congestive heart failure | |
| Very rare (<4-1%) | ||
| HP:0000707 | Abnormality of the nervous system | |
| HP:0002383 | Infectious encephalitis | |
| HP:0009830 | Peripheral neuropathy | |
Annotation source: 26513769[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/3386
- This record as JSON: /data/d/3386.json