African trypanosomiasis
Synonyms: Sleeping sickness
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare parasitic disease characterized by infection with the protozoans <i>Trypanosoma brucei rhodesiense</i> (East African trypanosomiasis) or <i>T. brucei gambiense</i> (West African trypanosomiasis), usually due to the bite of an infected tsetse fly. The first, hemolymphatic stage presents with fever, headaches, fatigue, lymphadenopathy, and aching muscles and joints. In East African trypanosomiasis, the fly bite may develop into a red sore or chancre. This form then progresses to CNS invasion with somnolence and other neurologic and psychiatric symptoms within a few weeks, while West African trypanosomiasis slowly progresses within about 3 years. Both forms are fatal if left untreated.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | African trypanosomiasis | Sleeping sickness |
| fr | Trypanosomiase africaine | Maladie du sommeil · Trypanosomose africaine |
| de | Afrikanische Trypanosomiasis | Schlafkrankheit |
| es | Tripanosomiasis africana | |
| it | Tripanosomiasi africana | |
| nl | Afrikaanse trypanosomiase | Slaapziekte |
| pt | Tripanossomíase Africana | |
| pl | Trypanosomatoza afrykańska | Śpiączka |
| cs | Trypanozomóza africká | Spavá nemoc |
| uk | Африканський трипаносомоз | Сонна хвороба |
| zh | 非洲锥虫病 | 非洲睡眠病 |
| tr | Afrika tripanozomiyazı | Uyku hastalığı |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B56.0 | BTNT | specific | validated |
| ICD-10 | B56.1 | BTNT | specific | validated |
| ICD-10 | B56.9 | BTNT | specific | validated |
| ICD-11 | 1F51 | E | specific | validated |
| MONDO | 0005459 | E | validated | |
| MeSH | D014353 | E | validated | |
| UMLS | C0041228 | E | validated | |
| GARD | 7826 | E | validated | |
| MedDRA | 10001461 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163588Rare parasitic disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | 23260189[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
87 annotations · validated 2020-04-08| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000707 | Abnormality of the nervous system | |
| HP:0001262 | Excessive daytime somnolence | |
| HP:0030050 | Narcolepsy | |
| HP:0032323 | Periodic fever | |
| HP:0002360 | Sleep abnormality | |
| HP:0006979 | Sleep-wake cycle disturbance | |
| Frequent (79-30%) | ||
| HP:0003115 | Abnormal EKG | |
| HP:0012751 | Abnormal basal ganglia MRI signal intensity | |
| HP:0002500 | Abnormal cerebral white matter morphology | |
| HP:0002494 | Abnormal rapid eye movement sleep | |
| HP:0011442 | Abnormality of central motor function | |
| HP:0000741 | Apathy | |
| HP:0410263 | Brain imaging abnormality | |
| HP:0012378 | Fatigue | |
| HP:0001288 | Gait disturbance | |
| HP:0002315 | Headache | |
| HP:0002240 | Hepatomegaly | |
| HP:0001433 | Hepatosplenomegaly | |
| HP:0100785 | Insomnia | |
| HP:0002716 | Lymphadenopathy | |
| HP:0001324 | Muscle weakness | |
| HP:0000989 | Pruritus | |
| HP:0025145 | Rigors | |
| HP:0001744 | Splenomegaly | |
| HP:0001824 | Weight loss | |
| Occasional (29-5%) | ||
| HP:0032367 | Abnormal growth hormone level | |
| HP:0040086 | Abnormal prolactin level | |
| HP:0011731 | Abnormality of circulating cortisol level | |
| HP:0000847 | Abnormality of renin-angiotensin system | |
| HP:0002167 | Abnormality of speech or vocalization | |
| HP:0000818 | Abnormality of the endocrine system | |
| HP:0000140 | Abnormality of the menstrual cycle | |
| HP:0000718 | Aggressive behavior | |
| HP:0002304 | Akinesia | |
| HP:0001596 | Alopecia | |
| HP:0000739 | Anxiety | |
| HP:0002829 | Arthralgia | |
| HP:0000708 | Atypical behavior | |
| HP:0001266 | Choreoathetosis | |
| HP:0000509 | Conjunctivitis | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0002014 | Diarrhea | |
| HP:0000651 | Diplopia | |
| HP:0005521 | Disseminated intravascular coagulation | |
| HP:0100660 | Dyskinesia | |
| HP:0002380 | Fasciculations | |
| HP:0001288 | Gait disturbance | |
| HP:0000771 | Gynecomastia | |
| HP:0001269 | Hemiparesis | |
| HP:0010831 | Impaired proprioception | |
| HP:0000802 | Impotence | |
| HP:0000789 | Infertility | |
| HP:0004305 | Involuntary movements | |
| HP:0001101 | Iritis | |
| HP:0000737 | Irritability | |
| HP:0000952 | Jaundice | |
| HP:0000491 | Keratitis | |
| HP:0007178 | Motor polyneuropathy | |
| HP:0002018 | Nausea | |
| HP:0100653 | Optic neuritis | |
| HP:0003470 | Paralysis | |
| HP:0003401 | Paresthesia | |
| HP:0002476 | Primitive reflex | |
| HP:0001345 | Psychotic mentation | |
| HP:0004372 | Reduced consciousness | |
| HP:0000083 | Renal insufficiency | |
| HP:0011706 | Second degree atrioventricular block | |
| HP:0003474 | Somatic sensory dysfunction | |
| HP:0001709 | Third degree atrioventricular block | |
| HP:0001337 | Tremor | |
| HP:0000020 | Urinary incontinence | |
| HP:0002119 | Ventriculomegaly | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0011675 | Arrhythmia | |
| HP:0001259 | Coma | |
| HP:0001635 | Congestive heart failure | |
| HP:0031258 | Delirium | |
| HP:0025475 | Erythematous macule | |
| HP:0000738 | Hallucinations | |
| HP:0012486 | Myelitis | |
| HP:0002196 | Myelopathy | |
| HP:0012819 | Myocarditis | |
| HP:0001085 | Papilledema | |
| HP:0001701 | Pericarditis | |
| HP:0001622 | Premature birth | |
| HP:0001250 | Seizure | |
| HP:0005268 | Spontaneous abortion | |
Run the differential on the 6 obligate / very frequent terms
Annotation source: 23260189[PMID]_22632638[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/3385
- This record as JSON: /data/d/3385.json