Classic heparin-induced thrombocytopenia
Synonyms: Classic HAT · Classic HIT · Classic heparin-associated thrombocytopenia · HITT · Heparin-induced-immune thrombocytopenia
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare drug-induced, immune-mediated prothrombotic disorder associated with thrombocytopenia and venous and/or arterial thrombosis.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Classic heparin-induced thrombocytopenia | Classic HAT · Classic HIT · Classic heparin-associated thrombocytopenia · HITT · Heparin-induced-immune thrombocytopenia |
| fr | Thrombopénie induite par l'héparine classique | TIH classique · Thrombocytopénie héparino-induite classique · Thrombocytopénie induite par l'héparine classique · Thrombopénie héparino-induite classique |
| de | Heparin-induzierte Thrombozytopenie, klassische | Immunthrombozytopenie, Heparin-induzierte · Klassische HIT · Klassische Heparin-assoziierte Thrombozytopenie |
| es | Trombocitopenia clásica inducida por heparina | TIH clásica · Trombocitopenia clásica asociada a heparina · Trombocitopenia inmune inducida por heparina |
| it | Trombocitopenia indotta dall'eparina | HAT · HIT · Trombocitopenia indotta dall'eparina, tipo 2 |
| nl | Klassieke heparinegeïnduceerde trombocytopenie | HITT · Heparinegeïnduceerde immuuntrombocytopenie · Klassieke HAT · Klassieke HIT · Klassieke heparinegeassocieerde trombocytopenie |
| pt | Trombocitopenia clássica induzida por heparina | HAT clássica · HIT clássica · HITT · Trombocitopenia clássica heparina-associada · Trombocitopenia imune induzida por heparina |
| pl | Małopłytkowość indukowana heparyną | HAT · HIT · Małopłytkowość indukowana heparyną typu 2 · Małopłytkowość wywołana heparyną |
| cs | Heparinem indukovaná trombocytopenie | HAT · HIT · Heparinem indukovaná trombocytopenie, typ 2 |
| uk | Гепарин-індукована тромбоцитопенія | HAT · Гепарин-асоційована тромбоцитопенія · Гепарин-індукована тромбоцитопенія типу 2 · HIT |
| zh | 肝素诱导性血小板减少症 | 肝素诱导性血小板减少症2型 |
| tr | Heparine bağlı trombositopeni | HAT · HIT · Heparin-ilişkili trombositopeni · Heparin kaynaklı trombositopeni tip 2 |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D69.5 | NTBT | attributed | validated |
| ICD-11 | 3B64.12 | NTBT | index | validated |
| MONDO | 0018048 | E | validated | |
| UMLS | C0272285 | E | validated | |
| GARD | 2650 | E | validated | |
| MedDRA | 10062506 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:698914Platelet-activating anti-platelet factor 4 disorder
rare hematological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
15 annotations · validated 2019-04-23| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001973 | Autoimmune thrombocytopenia | |
| HP:0100724 | Hypercoagulability | |
| HP:0001907 | Thromboembolism | |
| Frequent (79-30%) | ||
| HP:0004420 | Arterial thrombosis | |
| HP:0002625 | Deep venous thrombosis | |
| HP:0003144 | Increased serum serotonin | |
| HP:0004936 | Venous thrombosis | |
| Occasional (29-5%) | ||
| HP:0002637 | Cerebral ischemia | |
| HP:0005521 | Disseminated intravascular coagulation | |
| HP:0012649 | Increased inflammatory response | |
| HP:0030248 | Mesenteric venous thrombosis | |
| HP:0001658 | Myocardial infarction | |
| HP:0002204 | Pulmonary embolism | |
| HP:0001297 | Stroke | |
| Very rare (<4-1%) | ||
| HP:0040231 | Abnormal onset of bleeding | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 29649767[PMID]_27230048[PMID]_30126928[PMID]_30284726[PMID]_30502310[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/3325
- This record as JSON: /data/d/3325.json