{"orpha":3325,"name":"Classic heparin-induced thrombocytopenia","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Classic HAT","Classic HIT","Classic heparin-associated thrombocytopenia","HITT","Heparin-induced-immune thrombocytopenia"],"definition":"A rare drug-induced, immune-mediated prothrombotic disorder associated with thrombocytopenia and venous and/or arterial thrombosis.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-3325/","orphanet_url":"https://www.orpha.net/en/disease/detail/3325","names":{"fr":{"name":"Thrombopénie induite par l'héparine classique","synonyms":["TIH classique","Thrombocytopénie héparino-induite classique","Thrombocytopénie induite par l'héparine classique","Thrombopénie héparino-induite classique"],"definition":"Maladie prothrombotique immunitaire d'origine médicamenteuse associant une thrombopénie et une thrombose veineuse et/ou artérielle."},"de":{"name":"Heparin-induzierte Thrombozytopenie, klassische","synonyms":["Immunthrombozytopenie, Heparin-induzierte","Klassische HIT","Klassische Heparin-assoziierte Thrombozytopenie"],"definition":"Eine seltene medikamenteninduzierte, immunvermittelte prothrombotische Störung, die mit Thrombozytopenie und venösen und/oder arteriellen Thrombosen einhergeht."},"es":{"name":"Trombocitopenia clásica inducida por heparina","synonyms":["TIH clásica","Trombocitopenia clásica asociada a heparina","Trombocitopenia inmune inducida por heparina"],"definition":"Es un trastorno protrombótico de mecanismo inmune e inducido por fármacos, poco frecuente y asociado a trombocitopenia y trombosis venosa y/o arterial."},"it":{"name":"Trombocitopenia indotta dall'eparina","synonyms":["HAT","HIT","Trombocitopenia indotta dall'eparina, tipo 2"],"definition":"La trombocitopenia indotta dall'eparina (HIT) è una malattia protrombotica rara, immuno-mediata e farmaco-indotta, associata a trombocitopenia e trombosi venosa e/o arteriosa."},"nl":{"name":"Klassieke heparinegeïnduceerde trombocytopenie","synonyms":["HITT","Heparinegeïnduceerde immuuntrombocytopenie","Klassieke HAT","Klassieke HIT","Klassieke heparinegeassocieerde trombocytopenie"],"definition":"Een zeldzame door geneesmiddel geïnduceerde, immuungemedieerde protrombotische aandoening, geassocieerd met trombocytopenie en veneuze en/of arteriële trombose."},"pt":{"name":"Trombocitopenia clássica induzida por heparina","synonyms":["HAT clássica","HIT clássica","HITT","Trombocitopenia clássica heparina-associada","Trombocitopenia imune induzida por heparina"],"definition":"Distúrbio pró-trombótico por desregulação imune, induzida por fármacos, raro, associado a trombocitopenia e trombose venosa e/ou arterial."},"pl":{"name":"Małopłytkowość indukowana heparyną","synonyms":["HAT","HIT","Małopłytkowość indukowana heparyną typu 2","Małopłytkowość wywołana heparyną"]},"cs":{"name":"Heparinem indukovaná trombocytopenie","synonyms":["HAT","HIT","Heparinem indukovaná trombocytopenie, typ 2"]},"uk":{"name":"Гепарин-індукована тромбоцитопенія","synonyms":["HAT","Гепарин-асоційована тромбоцитопенія","Гепарин-індукована тромбоцитопенія типу 2","HIT"],"definition":"A rare drug-induced, immune-mediated prothrombotic disorder associated with thrombocytopenia and venous and/or arterial thrombosis."},"zh":{"name":"肝素诱导性血小板减少症","synonyms":["肝素诱导性血小板减少症2型"]},"tr":{"name":"Heparine bağlı trombositopeni","synonyms":["HAT","HIT","Heparin-ilişkili trombositopeni","Heparin kaynaklı trombositopeni tip 2"]}},"xrefs":[{"source":"ICD-10","code":"D69.5","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"3B64.12","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1143142333"},{"source":"MONDO","code":"0018048","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0272285","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"2650","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10062506","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":698914,"name":"Platelet-activating anti-platelet factor 4 disorder","classifications":[194]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-04-23","source":"29649767[PMID]_27230048[PMID]_30126928[PMID]_30284726[PMID]_30502310[PMID]","terms":[{"hpo":"HP:0001973","label":"Autoimmune thrombocytopenia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100724","label":"Hypercoagulability","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001907","label":"Thromboembolism","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0004420","label":"Arterial thrombosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002625","label":"Deep venous thrombosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003144","label":"Increased serum serotonin","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004936","label":"Venous thrombosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002637","label":"Cerebral ischemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012649","label":"Increased inflammatory response","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030248","label":"Mesenteric venous thrombosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001658","label":"Myocardial infarction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002204","label":"Pulmonary embolism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001297","label":"Stroke","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040231","label":"Abnormal onset of bleeding","frequency":"Very rare (<4-1%)","criteria":null}]}}