ORPHA:3299
Tetanus
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
A toxin-mediated infection due to the anaerobic bacteria <i>Clostridium tetani</i> and characterized by spasms and contractions of the skeletal muscles, the disease is often lethal.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Tetanus | |
| fr | Tétanos | |
| de | Tetanus | Wundstarrkrampf |
| es | Tétanos | |
| it | Tetano | |
| nl | Tetanus | |
| pt | Tétano | |
| pl | Tężec | |
| cs | Tetanus | |
| uk | Правець | |
| zh | 破伤风 | |
| tr | Tetanoz |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A33 | BTNT | specific | validated |
| ICD-10 | A34 | BTNT | specific | validated |
| ICD-10 | A35 | BTNT | specific | validated |
| ICD-11 | 1C13 | BTNT | specific | validated |
| ICD-11 | 1C14 | BTNT | specific | validated |
| ICD-11 | 1C15 | BTNT | specific | validated |
| MONDO | 0005526 | E | validated | |
| MeSH | D013742 | E | validated | |
| UMLS | C0039614 | E | validated | |
| GARD | 5144 | E | validated | |
| MedDRA | 10043376 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:98010Infectious disease of the nervous system
rare neurological diseases - ORPHA:163582Rare bacterial infectious disease
rare infectious diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
24 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.014 / 100 000 | France | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.024 / 100 000 | Europe | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.044 / 100 000 | Malta | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.014 / 100 000 | Bulgaria | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.028 / 100 000 | Croatia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.004 / 100 000 | Czech Republic | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.014 / 100 000 | Denmark | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.032 / 100 000 | Estonia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.036 / 100 000 | Greece | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.024 / 100 000 | Hungary | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.016 / 100 000 | Ireland | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.076 / 100 000 | Italy | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.07 / 100 000 | Lithuania | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.008 / 100 000 | Netherlands | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.012 / 100 000 | Norway | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.032 / 100 000 | Poland | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.008 / 100 000 | Portugal | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.032 / 100 000 | Romania | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.118 / 100 000 | Slovenia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.016 / 100 000 | Spain | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Sweden | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | United Kingdom | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | Slovakia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Point prevalence | Unknown | — | Europe | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
6
HPO phenotypes
30 annotations · validated 2019-11-15| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002015 | Dysphagia | |
| HP:0003552 | Muscle stiffness | |
| HP:0002179 | Opisthotonus | |
| HP:0040212 | Risus sardonicus | |
| HP:0000211 | Trismus | |
| Frequent (79-30%) | ||
| HP:0001945 | Fever | |
| HP:0005363 | Humoral immunodeficiency | |
| HP:0001276 | Hypertonia | |
| HP:0011964 | Intermittent painful muscle spasms | |
| HP:0011355 | Localized skin lesion | |
| HP:0002063 | Rigidity | |
| HP:0025258 | Stiff neck | |
| HP:0001649 | Tachycardia | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0012332 | Abnormal autonomic nervous system physiology | |
| HP:0005341 | Autonomic bladder dysfunction | |
| HP:0002607 | Bowel incontinence | |
| HP:0001662 | Bradycardia | |
| HP:0001259 | Coma | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0003236 | Elevated circulating creatine kinase concentration | |
| HP:0003639 | Elevated urinary epinephrine | |
| HP:0003345 | Elevated urinary norepinephrine | |
| HP:0000822 | Hypertension | |
| HP:0025425 | Laryngospasm | |
| HP:0002098 | Respiratory distress | |
| HP:0025145 | Rigors | |
| HP:0002501 | Spasticity of pharyngeal muscles | |
| HP:0002789 | Tachypnea | |
| HP:0001337 | Tremor | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 30935736[PMID]_31687615[PMID]
7
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/3299
- This record as JSON: /data/d/3299.json