{"orpha":3299,"name":"Tetanus","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A toxin-mediated infection due to the anaerobic bacteria <i>Clostridium tetani</i> and characterized by spasms and contractions of the skeletal muscles, the disease is often lethal.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-3299/","orphanet_url":"https://www.orpha.net/en/disease/detail/3299","names":{"fr":{"name":"Tétanos","definition":"Une toxi-infection due à la bactérie anaérobie <i>Clostridium tetani</i> et caractérisée par des spasmes et des contractures des muscles squelettiques. La maladie est souvent létale."},"de":{"name":"Tetanus","synonyms":["Wundstarrkrampf"],"definition":"Es handelt sich um eine toxinvermittelte Infektion durch das anaerobe Bakterium <i>Clostridium tetani</i>, die durch Krämpfe und Kontraktionen der Skelettmuskulatur gekennzeichnet ist und häufig tödlich verläuft."},"es":{"name":"Tétanos","definition":"Es una infección mediada por toxinas producida por la bacteria anaerobia <i>Clostridium tetani</i> y caracterizada por espasmos y contracciones de los músculos esqueléticos, la enfermedad suele ser letal."},"it":{"name":"Tetano","definition":"Si tratta di un'infezione mediata da una tossina prodotta dal batterio anaerobico <i>Clostridium tetani</i>, e caratterizzata da spasmi e contrazioni dei muscoli scheletrici. La malattia è spesso letale."},"nl":{"name":"Tetanus","definition":"Een infectie door toxine van de anaerobe bacterie <i>Clostridium tetani</i>, gekarakteriseerd door spasmen en contracties van skeletspieren, en vaak letale afloop."},"pt":{"name":"Tétano","definition":"O tétano é uma doença infecciosa causada pela bactéria anaeróbica <i>Clostridium tetani</i> e caracterizada por espasmos e contracções dos músculos esqueléticos."},"pl":{"name":"Tężec"},"cs":{"name":"Tetanus"},"uk":{"name":"Правець","definition":"A toxin-mediated infection due to the anaerobic bacteria <i>Clostridium tetani</i> and characterized by spasms and contractions of the skeletal muscles, the disease is often lethal."},"zh":{"name":"破伤风"},"tr":{"name":"Tetanoz"}},"xrefs":[{"source":"ICD-10","code":"A33","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A34","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A35","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C13","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1793762788"},{"source":"ICD-11","code":"1C14","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"262236278"},{"source":"ICD-11","code":"1C15","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"2085616610"},{"source":"MONDO","code":"0005526","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D013742","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0039614","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5144","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10043376","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":98010,"name":"Infectious disease of the nervous system","classifications":[181]},{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.014,"area":"France","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.024,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.044,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.014,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.028,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.004,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.014,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.032,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.036,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.024,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.016,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.076,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.07,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.008,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.012,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.032,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.008,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.032,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.118,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.016,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-11-15","source":"30935736[PMID]_31687615[PMID]","terms":[{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003552","label":"Muscle stiffness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002179","label":"Opisthotonus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0040212","label":"Risus sardonicus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000211","label":"Trismus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005363","label":"Humoral immunodeficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001276","label":"Hypertonia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011964","label":"Intermittent painful muscle spasms","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011355","label":"Localized skin lesion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002063","label":"Rigidity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025258","label":"Stiff neck","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012332","label":"Abnormal autonomic nervous system physiology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005341","label":"Autonomic bladder dysfunction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002607","label":"Bowel incontinence","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003639","label":"Elevated urinary epinephrine","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003345","label":"Elevated urinary norepinephrine","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025425","label":"Laryngospasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025145","label":"Rigors","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002501","label":"Spasticity of pharyngeal muscles","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Occasional (29-5%)","criteria":null}]}}