MAGIC syndrome
Synonyms: Mouth and genital ulcers-inflamed cartilage syndrome
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Adult, Childhood
- Status
- active
A rare autoinflammatory syndrome characterized by the presence of features of relapsing polychondritis and Behçet's disease in the same individual. This includes cartilage inflammation of the ears, nose, throat, and rib cage, as well as recurrent oral and genital ulcers, respectively. Patients may also present ocular involvement (in particular anterior uveitis or scleritis), arthritis, fever, colitis, thrombophlebitis, central nervous system vasculitis, or, in rare cases, arterial aneurysms. Symptoms of polychondritis occur secondary to those of Behçet's disease in the vast majority of cases.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | MAGIC syndrome | Mouth and genital ulcers-inflamed cartilage syndrome |
| fr | Syndrome MAGIC | Aphtose bipolaire avec chondrites récidivantes |
| de | MAGIC-Syndrom | Mund- und Genital-Ulzera mit Chondritis |
| es | Síndrome MAGIC | Cartílago inflamado con úlceras bucales y genitales |
| it | Sindrome MAGIC | Ulcere buccali e genitali con infiammazione della cartilagine |
| nl | MAGIC-syndroom | Ulcera van mond en genitaliën - ontstoken kraakbeen-syndroom |
| pt | Síndrome de MAGIC | |
| pl | Zespół MAGIC | Wrzody ust i narządów płciowych z zapaleniem chrząstek |
| cs | MAGIC syndrom | Vředy úst a genitálu se zanícenými chrupavkami |
| uk | Синдром MAGIC | Синдром запалення хрящів при виразках ротової порожнини та статевих органів |
| zh | MAGIC综合征 | 口腔和生殖器溃疡-软骨发炎综合征 |
| tr | MAGIC sendromu | Ağız ve genital ülserler-iltihaplı kıkırdak sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D89.8 | NTBT | attributed | validated |
| MONDO | 0017958 | E | validated | |
| UMLS | C0406568 | E | validated | |
| GARD | 13371 | E | validated | |
| MedDRA | 10078132 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:324936Unclassified autoinflammatory syndrome
rare systemic and rheumatological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 21 cases | Worldwide | Case(s) | Validated | 27293269[PMID] | |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | ORPHANET_27293269[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
15 annotations · validated 2025-12-19| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0200047 | Chondritis of pinna | |
| HP:0003249 | Genital ulcers | |
| HP:0000155 | Oral ulcer | |
| Frequent (79-30%) | ||
| HP:0000509 | Conjunctivitis | |
| HP:0100534 | Episcleritis | |
| HP:0012219 | Erythema nodosum | |
| HP:0000491 | Keratitis | |
| HP:0033380 | Nasal chondritis | |
| HP:0025532 | Positive pathergy test | |
| HP:0030880 | Raynaud phenomenon | |
| HP:0100532 | Scleritis | |
| Occasional (29-5%) | ||
| HP:0003493 | Antinuclear antibody positivity | |
| HP:0004942 | Aortic aneurysm | |
| HP:0001907 | Thromboembolism | |
| HP:0200029 | Vasculitis in the skin | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 24626673[PMID]_32914210[PMID]_34972595[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/324972
- This record as JSON: /data/d/324972.json