{"orpha":324972,"name":"MAGIC syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Mouth and genital ulcers-inflamed cartilage syndrome"],"definition":"A rare autoinflammatory syndrome characterized by the presence of features of relapsing polychondritis and Behçet's disease in the same individual. This includes cartilage inflammation of the ears, nose, throat, and rib cage, as well as recurrent oral and genital ulcers, respectively. Patients may also present ocular involvement (in particular anterior uveitis or scleritis), arthritis, fever, colitis, thrombophlebitis, central nervous system vasculitis, or, in rare cases, arterial aneurysms. Symptoms of polychondritis occur secondary to those of Behçet's disease in the vast majority of cases.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-324972/","orphanet_url":"https://www.orpha.net/en/disease/detail/324972","names":{"fr":{"name":"Syndrome MAGIC","synonyms":["Aphtose bipolaire avec chondrites récidivantes"],"definition":"Syndrome auto-inflammatoire rare caractérisé par l'association chez le même individu de signes cliniques de la polychondrite récidivante et de la maladie de Behçet, à savoir, l'inflammation du cartilage des oreilles, du nez, de la gorge et de la cage thoracique, des atteintes buccales et génitales récurrentes. Les patients peuvent également présenter une atteinte oculaire (en particulier une uvéite ou une sclérite antérieure), de l'arthrite, de la fièvre, une colite, une thrombophlébite, une vascularite du système nerveux central ou, dans de rares cas, des anévrismes artériels. Dans la grande majorité des cas, les symptômes de la polychondrite sont secondaires à ceux de la maladie de Behçet."},"de":{"name":"MAGIC-Syndrom","synonyms":["Mund- und Genital-Ulzera mit Chondritis"],"definition":"Ein seltenes autoinflammatorisches Syndrom, das durch das Vorhandensein von Merkmalen der rezidivierenden Polychondritis und des Morbus Behçet bei ein und derselben Person gekennzeichnet ist. Dazu gehören Knorpelentzündungen der Ohren, der Nase, des Rachens und des Brustkorbs sowie rezidivierende orale und genitale Ulzerationen. Die Patienten können auch eine Augenbeteiligung (insbesondere anteriore Uveitis oder Skleritis), Arthritis, Fieber, Kolitis, Thrombophlebitis, Vaskulitis des zentralen Nervensystems oder, in seltenen Fällen, arterielle Aneurysmen aufweisen. Die Symptome der Polychondritis treten in der überwiegenden Mehrzahl der Fälle sekundär zum Morbus Behçet auf."},"es":{"name":"Síndrome MAGIC","synonyms":["Cartílago inflamado con úlceras bucales y genitales"],"definition":"Es un síndrome autoinflamatorio poco frecuente caracterizado por la presencia de rasgos de policondritis recidivante y enfermedad de Behçet en el mismo individuo. Incluye la inflamación del cartílago de las orejas, la nariz, la laringe y la caja torácica, así como úlceras bucales y genitales recurrentes, respectivamente. Los pacientes también pueden presentar afectación ocular (en particular uveítis o escleritis anterior), artritis, fiebre, colitis, tromboflebitis, vasculitis del sistema nervioso central o, en raras ocasiones, aneurismas arteriales. Los síntomas de la policondritis aparecen después de los de la enfermedad de Behçet en la gran mayoría de los casos."},"it":{"name":"Sindrome MAGIC","synonyms":["Ulcere buccali e genitali con infiammazione della cartilagine"],"definition":"Si tratta di una malattia autoinfiammatoria rara, caratterizzata dai segni clinici della policondrite recidivante, associati a quelli della malattia di Behçet, che comprendono l'infiammazione della cartilagine delle orecchie, del naso, della gola e della gabbia toracica, e le ulcere ricorrenti nella bocca e nei genitali. I pazienti possono presentare anche un interessamento oculare (in particolare uveite anteriore o sclerite), artrite, febbre, colite, tromboflebite, vasculite del sistema nervoso centrale e, raramente, aneurismi arteriosi. Nella maggior parte dei pazienti i sintomi della policondrite esordiscono dopo quelli della malattia di Behçet."},"nl":{"name":"MAGIC-syndroom","synonyms":["Ulcera van mond en genitaliën - ontstoken kraakbeen-syndroom"],"definition":"Een zeldzaam auto-inflammatoir syndroom, gekarakteriseerd door de aanwezigheid van kenmerken van recidiverende polychondritis en ziekte van Behçet bij hetzelfde individu. Deze zijn respectievelijk ontsteking van kraakbeen van oor, neus, keel en ribbenkast, en recidiverende ulcera van mond en geslachtsorganen. Patiënten presenteren zich mogelijk ook met betrokkenheid van oog (vooral anterieure uveïtis of scleritis), artritis, koorts, colitis, tromboflebitis, vasculitis van centraal zenuwstelsel, of, in zeldzame gevallen, arterieel aneurysma. Bij het overgrote deel van de gevallen zijn symptomen van polychondritis secundair aan die van ziekte van Behçet."},"pt":{"name":"Síndrome de MAGIC"},"pl":{"name":"Zespół MAGIC","synonyms":["Wrzody ust i narządów płciowych z zapaleniem chrząstek"]},"cs":{"name":"MAGIC syndrom","synonyms":["Vředy úst a genitálu se zanícenými chrupavkami"]},"uk":{"name":"Синдром MAGIC","synonyms":["Синдром запалення хрящів при виразках ротової порожнини та статевих органів"],"definition":"A rare autoinflammatory syndrome characterized by the presence of features of relapsing polychondritis and Behçet's disease in the same individual. This includes cartilage inflammation of the ears, nose, throat, and rib cage, as well as recurrent oral and genital ulcers, respectively. Patients may also present ocular involvement (in particular anterior uveitis or scleritis), arthritis, fever, colitis, thrombophlebitis, central nervous system vasculitis, or, in rare cases, arterial aneurysms. Symptoms of polychondritis occur secondary to those of Behçet's disease in the vast majority of cases."},"zh":{"name":"MAGIC综合征","synonyms":["口腔和生殖器溃疡-软骨发炎综合征"],"definition":"一种罕见的自身炎症综合征，其特征是同一个体中存在复发性多软骨炎和白塞病。表现包括耳朵、鼻子、喉咙和胸腔的软骨发炎，以及复发性口腔溃疡和生殖器溃疡。患者还可能出现眼部受累（尤其是前葡萄膜炎或巩膜炎）、关节炎、发热、结肠炎、血栓性静脉炎、中枢神经系统血管炎，动脉瘤罕见。在绝大多数病例中，多软骨炎的症状仅次于白塞病。"},"tr":{"name":"MAGIC sendromu","synonyms":["Ağız ve genital ülserler-iltihaplı kıkırdak sendromu"]}},"xrefs":[{"source":"ICD-10","code":"D89.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0017958","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0406568","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"13371","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10078132","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":324936,"name":"Unclassified autoinflammatory syndrome","classifications":[196]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":21.0,"area":"Worldwide","status":"Validated","source":"27293269[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_27293269[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2025-12-19","source":"24626673[PMID]_32914210[PMID]_34972595[PMID]","terms":[{"hpo":"HP:0200047","label":"Chondritis of pinna","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003249","label":"Genital ulcers","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000155","label":"Oral ulcer","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100534","label":"Episcleritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012219","label":"Erythema nodosum","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000491","label":"Keratitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0033380","label":"Nasal chondritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025532","label":"Positive pathergy test","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030880","label":"Raynaud phenomenon","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100532","label":"Scleritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003493","label":"Antinuclear antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004942","label":"Aortic aneurysm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001907","label":"Thromboembolism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200029","label":"Vasculitis in the skin","frequency":"Occasional (29-5%)","criteria":null}]}}