Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis
Synonyms: CNO/CRMO
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Childhood
- Status
- active
Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a chronic autoinflammatory syndrome that is characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis | CNO/CRMO |
| fr | Ostéomyélite chronique non-bactérienne/Ostéomyélite multifocale chronique récurrente | CNO/CRMO · OCN/OMCR |
| de | Chronische nicht-bakterielle Osteomyelitis/rezidivierende multifokale Osteomyelitis | = en |
| es | Osteomielitis crónica no bacteriana/Osteomielitis crónica multifocal recurrente | = en |
| it | Osteomielite multifocale ricorrente cronica | CRMO |
| nl | Chronische niet-bacteriële osteomyelitis/Chronische terugkerende multifocale osteomyelitis | = en |
| pt | Osteomielite crónica multifocal recorrente | |
| pl | Przewlekłe nawracające wielookniskowe zapalenie kości i szpiku kostnego | CRMO |
| cs | Chronický návratný víceložiskový kostní zánět | CRMO |
| uk | Хронічний небактеріальний остеомієліт/Хронічний рецидивуючий мультифокальний остеомієліт | = en |
| zh | 慢性复发性多灶性骨髓炎 | CNO/CRMO病 |
| tr | Kronik bakteriyel olmayan osteomiyelit / Kronik tekrarlayan multifokal osteomiyelit | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 259680 | E | validated | |
| ICD-10 | M86.3 | E | specific | validated |
| ICD-11 | 4A6Y | NTBT | index | validated |
| MONDO | 9813 | E | validated | |
| UMLS | C5679877 | E | validated | |
| GARD | 6108 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (3):
- ORPHA:290842Autoinflammatory syndrome with skin involvement
rare skin diseases - ORPHA:324927Pyogenic autoinflammatory syndrome
rare systemic and rheumatological diseases - ORPHA:324942Pyogenic autoinflammatory syndrome of childhood
rare systemic or rheumatologic diseases of childhood
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:2778OBSOLETE: Juvenile chronic recurrent multifocal osteomyelitis referred to · inactive
- ORPHA:57194OBSOLETE: Aseptic osteitis referred to · inactive
- ORPHA:93668OBSOLETE: Adult chronic recurrent multifocal osteomyelitis referred to · inactive
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | 0.3 / 100 000 | Worldwide | Value and class | Validated | 12183714[PMID] |
| Annual incidence | 1-9 / 100 000 | 2.5 / 100 000 | Worldwide | Value and class | Validated | 12183714[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
27 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002653 | Bone pain | |
| HP:0100774 | Hyperostosis | |
| HP:0002754 | Osteomyelitis | |
| Frequent (79-30%) | ||
| HP:0000944 | Abnormal metaphysis morphology | |
| HP:0003468 | Abnormal vertebral morphology | |
| HP:0005930 | Abnormality of epiphysis morphology | |
| HP:0001369 | Arthritis | |
| HP:0005464 | Craniofacial osteosclerosis | |
| HP:0000969 | Edema | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0003565 | Elevated erythrocyte sedimentation rate | |
| HP:0012378 | Fatigue | |
| HP:0002797 | Osteolysis | |
| HP:0004396 | Poor appetite | |
| HP:0001824 | Weight loss | |
| Occasional (29-5%) | ||
| HP:0100781 | Abnormality of the sacroiliac joint | |
| HP:0001061 | Acne | |
| HP:0001903 | Anemia | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0001945 | Fever | |
| HP:0002037 | Inflammation of the large intestine | |
| HP:0100847 | Palmoplantar pustulosis | |
| HP:0000989 | Pruritus | |
| HP:0003765 | Psoriasiform dermatitis | |
| HP:0002650 | Scoliosis | |
| HP:0000988 | Skin rash | |
| HP:0002633 | Vasculitis | |
Run the differential on the 3 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/324964
- This record as JSON: /data/d/324964.json