{"orpha":324964,"name":"Chronic nonbacterial osteomyelitis/Chronic recurrent multifocal osteomyelitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["CNO/CRMO"],"definition":"Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a chronic autoinflammatory syndrome that is characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-324964/","orphanet_url":"https://www.orpha.net/en/disease/detail/324964","names":{"fr":{"name":"Ostéomyélite chronique non-bactérienne/Ostéomyélite multifocale chronique récurrente","synonyms":["CNO/CRMO","OCN/OMCR"],"definition":"L'ostéomyélite chronique non bactérienne (CNO), également appelée ostéomyélite multifocale chronique récurrente (CRMO), est un syndrome auto-inflammatoire chronique caractérisé par la présence de foyers multiples de tuméfaction douloureuse des os, principalement dans les métaphyses des os longs, ainsi que dans le pelvis, la ceinture scapulaire et la colonne vertébrale."},"de":{"name":"Chronische nicht-bakterielle Osteomyelitis/rezidivierende multifokale Osteomyelitis","synonyms":["CNO/CRMO"],"definition":"Die chronische, nicht-bakterielle Osteomyelitis (CNO), auch bekannt als chronisch-rezidivierende multifokale Osteomyelitis (CRMO), ist eine chronisches, autoinflammatorisches Syndrom und gekennzeichnet durch multiple, schmerzhaft geschwollene Knochenherde, besonders in den Metaphysen der langen Knochen, im Becken, in Schultergürtel und in der Wirbelsäule."},"es":{"name":"Osteomielitis crónica no bacteriana/Osteomielitis crónica multifocal recurrente","synonyms":["CNO/CRMO"],"definition":"La osteomielitis crónica no bacteriana (CNO), también conocida como osteomielitis crónica multifocal recurrente (CRMO), es un síndrome autoinflamatorio crónico caracterizado por múltiples focos de inflamación dolorosa de los huesos, principalmente en las metáfisis de los huesos largos, además de en la pelvis, la cintura escapular y la columna."},"it":{"name":"Osteomielite multifocale ricorrente cronica","synonyms":["CRMO"],"definition":"L'osteomielite cronica non batterica (CNO), nota anche come osteomielite multifocale ricorrente cronica (CRMO), è una sindrome infiammatoria cronica caratterizzata da foci multipli di infiammazione dolorosa delle ossa, in particolare nelle metafisi delle ossa lunghe, oltre al bacino, al cingolo scapolare e alla colonna vertebrale."},"nl":{"name":"Chronische niet-bacteriële osteomyelitis/Chronische terugkerende multifocale osteomyelitis","synonyms":["CNO/CRMO"],"definition":"Chronische niet-bacteriële osteomyelitis (CNO), ook gekend als chronische terugkerende multifocale osteomyelitis (CRMO), is een chronisch auto-inflammatoir syndroom dat wordt gekarakteriseerd door meerdere haarden van pijnlijke zwellingen aan de botten, vooral in de metafysen van de pijpbeenderen, alsook in het bekken, de schoudergordel en de wervelkolom."},"pt":{"name":"Osteomielite crónica multifocal recorrente"},"pl":{"name":"Przewlekłe nawracające wielookniskowe zapalenie kości i szpiku kostnego","synonyms":["CRMO"]},"cs":{"name":"Chronický návratný víceložiskový kostní zánět","synonyms":["CRMO"]},"uk":{"name":"Хронічний небактеріальний остеомієліт/Хронічний рецидивуючий мультифокальний остеомієліт","synonyms":["CNO/CRMO"],"definition":"Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a chronic autoinflammatory syndrome that is characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine."},"zh":{"name":"慢性复发性多灶性骨髓炎","synonyms":["CNO/CRMO病"],"definition":"慢性非细菌性骨髓炎（CNO）又称慢性复发性多灶性骨髓炎（CRMO），是一种以多灶性疼痛性骨肿胀为特征的慢性自身炎症综合征，除骨盆、肩带和脊柱外，病变主要位于长骨干骺端。"},"tr":{"name":"Kronik bakteriyel olmayan osteomiyelit / Kronik tekrarlayan multifokal osteomiyelit","synonyms":["CNO/CRMO"]}},"xrefs":[{"source":"OMIM","code":"259680","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"M86.3","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"4A6Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1256384247"},{"source":"MONDO","code":"9813","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5679877","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6108","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[{"type":"Referred to","orpha":2778,"name":"OBSOLETE: Juvenile chronic recurrent multifocal osteomyelitis","status":"inactive"},{"type":"Referred to","orpha":57194,"name":"OBSOLETE: Aseptic osteitis","status":"inactive"},{"type":"Referred to","orpha":93668,"name":"OBSOLETE: Adult chronic recurrent multifocal osteomyelitis","status":"inactive"}],"preferential_parent":{"orpha":98023,"name":"Rare systemic or rheumatologic disease"},"parents":[{"orpha":290842,"name":"Autoinflammatory syndrome with skin involvement","classifications":[187]},{"orpha":324927,"name":"Pyogenic autoinflammatory syndrome","classifications":[196]},{"orpha":324942,"name":"Pyogenic autoinflammatory syndrome of childhood","classifications":[231]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Childhood"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.3,"area":"Worldwide","status":"Validated","source":"12183714[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.5,"area":"Worldwide","status":"Validated","source":"12183714[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0002653","label":"Bone pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100774","label":"Hyperostosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000944","label":"Abnormal metaphysis morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003468","label":"Abnormal vertebral morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005930","label":"Abnormality of epiphysis morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005464","label":"Craniofacial osteosclerosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011227","label":"Elevated circulating C-reactive protein concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003565","label":"Elevated erythrocyte sedimentation rate","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002797","label":"Osteolysis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004396","label":"Poor appetite","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100781","label":"Abnormality of the sacroiliac joint","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001061","label":"Acne","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002037","label":"Inflammation of the large intestine","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100847","label":"Palmoplantar pustulosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003765","label":"Psoriasiform dermatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002650","label":"Scoliosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002633","label":"Vasculitis","frequency":"Occasional (29-5%)","criteria":null}]}}