ORPHA:324625
Chikungunya
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare infectious disease characterized by acute onset of high fever associated with debilitating polyarthralgia and usually accompanied by an erythematous skin rash (that may progress to vesiculobullous lesions in children) caused by the mosquitoe-borne Chikungunya virus. Myalgia, severe headache, and lymphadenopathy are frequently associated. Chronically the disease may cause recurrent, long-term polyarthralgia, arthritis, fatigue, and depression.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Chikungunya | |
| fr | Chikungunya | |
| de | Chikungunyafieber | |
| es | Chikungunya | |
| it | Chikungunya | |
| nl | Chikungunya | |
| pt | Chikungunya | |
| pl | Chikungunya | |
| cs | Chikungunya | |
| uk | Чикунгунья | |
| zh | 基孔肯雅热 | |
| tr | Chikungunya |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A92.0 | E | specific | validated |
| ICD-11 | 1D40 | E | specific | validated |
| MONDO | 0017941 | E | validated | |
| MeSH | D065632 | E | validated | |
| UMLS | C0008055 | E | validated | |
| GARD | 6038 | E | validated | |
| MedDRA | 10067256 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98252Infectious encephalitis
rare neurological diseases; rare infectious diseases
No children.
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
17 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.12 / 100 000 | Europe | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | France | Value and class | Validated | OTHERitut de Veille Sanitaire 2009[OTHER] |
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
| Annual incidence | 1-9 / 1 000 000 | 0.32 / 100 000 | Belgium | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.06 / 100 000 | Finland | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.13 / 100 000 | Germany | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.3 / 100 000 | Italy | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Latvia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.35 / 100 000 | Spain | Value and class | Validated | European Centre for Disease prevention and Control 2014-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.4 / 100 000 | Malta | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Slovenia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | — | Greece | Class only | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | — | Hungary | Class only | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | — | Ireland | Class only | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | <1 / 1 000 000 | — | Portugal | Class only | Validated | European Centre for Disease prevention and Control 2015-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.16 / 100 000 | Sweden | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.24 / 100 000 | United Kingdom | Value and class | Validated | European Centre for Disease prevention and Control 2013-2017[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
51 annotations · validated 2020-03-04| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002829 | Arthralgia | |
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| Frequent (79-30%) | ||
| HP:0000745 | Abnormal diminished volition | |
| HP:0001369 | Arthritis | |
| HP:0007483 | Depigmentation/hyperpigmentation of skin | |
| HP:0010783 | Erythema | |
| HP:0002315 | Headache | |
| HP:0001387 | Joint stiffness | |
| HP:0001386 | Joint swelling | |
| HP:0030839 | Knee pain | |
| HP:0012733 | Macule | |
| HP:0040186 | Maculopapular exanthema | |
| HP:0003326 | Myalgia | |
| HP:0010741 | Pedal edema | |
| HP:0030834 | Shoulder pain | |
| HP:0000988 | Skin rash | |
| HP:0005198 | Stiff interphalangeal joints | |
| Occasional (29-5%) | ||
| HP:0001892 | Abnormal bleeding | |
| HP:0008066 | Abnormal blistering of the skin | |
| HP:0032063 | Ankle joint effusion | |
| HP:0025232 | Bursitis | |
| HP:0025289 | Cervical lymphadenopathy | |
| HP:0025143 | Chills | |
| HP:0007473 | Crusting erythematous dermatitis | |
| HP:0000992 | Cutaneous photosensitivity | |
| HP:0000716 | Depression | |
| HP:0002014 | Diarrhea | |
| HP:0100686 | Enthesitis | |
| HP:0000421 | Epistaxis | |
| HP:0012219 | Erythema nodosum | |
| HP:0000282 | Facial edema | |
| HP:0000225 | Gingival bleeding | |
| HP:0040165 | Periostitis | |
| HP:0009830 | Peripheral neuropathy | |
| HP:0000967 | Petechiae | |
| HP:0000613 | Photophobia | |
| HP:0000989 | Pruritus | |
| HP:0025337 | Red eye | |
| HP:0200037 | Skin vesicle | |
| HP:0100769 | Synovitis | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0012185 | Constrictive median neuropathy | |
| HP:0002383 | Infectious encephalitis | |
| HP:0002716 | Lymphadenopathy | |
| HP:0031002 | Neuritis | |
| HP:0002797 | Osteolysis | |
| HP:0003401 | Paresthesia | |
| HP:0003406 | Peripheral nerve compression | |
| HP:0030880 | Raynaud phenomenon | |
| HP:0001250 | Seizure | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 28767976[PMID]_26601450[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/324625
- This record as JSON: /data/d/324625.json