{"orpha":324625,"name":"Chikungunya","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare infectious disease characterized by acute onset of high fever associated with debilitating polyarthralgia and usually accompanied by an erythematous skin rash (that may progress to vesiculobullous lesions in children) caused by the mosquitoe-borne Chikungunya virus. Myalgia, severe headache, and lymphadenopathy are frequently associated. Chronically the disease may cause recurrent, long-term polyarthralgia, arthritis, fatigue, and depression.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-324625/","orphanet_url":"https://www.orpha.net/en/disease/detail/324625","names":{"fr":{"name":"Chikungunya","definition":"Maladie infectieuse rare caractérisée par l'apparition brutale d'une forte fièvre associée à une polyarthralgie débilitante et généralement accompagnée d'une éruption cutanée érythémateuse (qui peut évoluer vers des lésions vésiculobulleuses chez les enfants) causée par le virus chikungunya transmis par les moustiques. Myalgie, céphalées sévères et lymphadénopathie sont fréquemment associées. Dans sa forme chronique, la maladie peut provoquer des polyarthralgies récurrentes et persistantes, une arthrite, une fatigue et une dépression."},"de":{"name":"Chikungunyafieber","definition":"Eine seltene Infektionskrankheit, die durch akut auftretendes hohes Fieber in Verbindung mit schwächender Polyarthralgie gekennzeichnet ist und in der Regel von einem erythematösen Hautausschlag begleitet wird (der bei Kindern zu vesikulobullösen Läsionen fortschreiten kann). Verursacht wird das Chikungunyafieber durch das Chikungunya-Virus, welches von Stechmücken übertragenen wird. Myalgie, starke Kopfschmerzen und Lymphadenopathie treten häufig auf. Chronisch kann die Krankheit wiederkehrende, langfristige Polyarthralgien, Arthritis, Müdigkeit und Depressionen verursachen."},"es":{"name":"Chikungunya","definition":"Es una enfermedad infecciosa poco frecuente caracterizada por un inicio agudo de fiebre alta asociada a poliartralgia debilitante y acompañada, por lo general, de una erupción cutánea eritematosa (que puede progresar a lesiones vesiculobullosas en niños) causada por el virus Chikungunya transmitido por mosquitos. Con frecuencia los síntomas asociados son mialgia, cefalea intensa y linfadenopatía. De forma crónica, la enfermedad puede causar poliartralgia recurrente a largo plazo, artritis, fatiga y depresión."},"it":{"name":"Chikungunya","definition":"È una malattia infettiva rara, caratterizzata da febbre alta ad esordio acuto, associata a poliartralgia debilitante e, di solito, ad un'eruzione cutanea eritematosa (che nei bambini può progredire verso le lesioni vescicolo-bollose), causata dal virus Chikungunya tramesso dalle zanzare. Spesso si associa a mialgia, grave cefalea e linfoadenopatia. La forma cronica della malattia può causare poliartralgia ricorrente nel lungo periodo, artrite, affaticamento e depressione."},"nl":{"name":"Chikungunya","definition":"Een zeldzame, infectieuze ziekte die gekarakteriseerd wordt door acute aanvang van hoge koorts, geassocieerd met invaliderende polyartralgie en doorgaans vergezeld van een erythemateuze huiduitslag (die kan evolueren tot vesiculobulleuze laesies bij kinderen) veroorzaakt door het door muggen overgedragen Chikungunya virus. Myalgie, ernstige hoofdpijn, en lymfadenopathie zijn vaak geassocieerd. Chronisch kan de ziekte recurrente, langdurige polyartralgie, artritis, vermoeidheid, en depressie veroorzaken."},"pt":{"name":"Chikungunya"},"pl":{"name":"Chikungunya"},"cs":{"name":"Chikungunya"},"uk":{"name":"Чикунгунья","definition":"A rare infectious disease characterized by acute onset of high fever associated with debilitating polyarthralgia and usually accompanied by an erythematous skin rash (that may progress to vesiculobullous lesions in children) caused by the mosquitoe-borne Chikungunya virus. Myalgia, severe headache, and lymphadenopathy are frequently associated. Chronically the disease may cause recurrent, long-term polyarthralgia, arthritis, fatigue, and depression."},"zh":{"name":"基孔肯雅热","definition":"一种罕见的传染病，特征是急性发热，伴有多发性关节痛，通常伴有由蚊传播的基孔肯雅病毒引起的红斑性皮疹（儿童可发展为水泡性皮疹）。肌痛、剧烈头痛和淋巴结肿大亦常见。慢性疾病可能导致复发性长期多关节痛、关节炎、疲劳和抑郁。"},"tr":{"name":"Chikungunya"}},"xrefs":[{"source":"ICD-10","code":"A92.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D40","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"900389391"},{"source":"MONDO","code":"0017941","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D065632","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0008055","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6038","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10067256","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":98252,"name":"Infectious encephalitis","classifications":[181,203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.12,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"France","status":"Validated","source":"OTHERitut de Veille Sanitaire 2009[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.32,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.06,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.13,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.3,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.35,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2014-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.4,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2015-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.16,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.24,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-04","source":"28767976[PMID]_26601450[PMID]","terms":[{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000745","label":"Abnormal diminished volition","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007483","label":"Depigmentation/hyperpigmentation of skin","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010783","label":"Erythema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001387","label":"Joint stiffness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001386","label":"Joint swelling","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030839","label":"Knee pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012733","label":"Macule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010741","label":"Pedal edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030834","label":"Shoulder pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005198","label":"Stiff interphalangeal joints","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008066","label":"Abnormal blistering of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032063","label":"Ankle joint effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025232","label":"Bursitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025289","label":"Cervical lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007473","label":"Crusting erythematous dermatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000992","label":"Cutaneous photosensitivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100686","label":"Enthesitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000421","label":"Epistaxis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012219","label":"Erythema nodosum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000282","label":"Facial edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000225","label":"Gingival bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040165","label":"Periostitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009830","label":"Peripheral neuropathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000967","label":"Petechiae","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025337","label":"Red eye","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200037","label":"Skin vesicle","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100769","label":"Synovitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012185","label":"Constrictive median neuropathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031002","label":"Neuritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002797","label":"Osteolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003406","label":"Peripheral nerve compression","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030880","label":"Raynaud phenomenon","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Very rare (<4-1%)","criteria":null}]}}