Colchicine poisoning
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Colchicine poisoning is a potentially life-threatening poisoning, due to ingestion of the drug or consumption of the plant <i>Colchicum autumnale</i>, that usually begins with gastrointestinal symptoms (e.g. abdominal pain, nausea, vomiting, and diarrhea, that cause severe dehydration) and an initial leukocytosis leading to marrow failure (24 hours after ingestion), followed by potentially fatal multi-organ failure with mental status change, oliguric renal failure, disseminated intravascular coagulation, electrolyte imbalance, acid-base disturbance, cardiac failure/arrest and shock within 1-3 days.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Colchicine poisoning | |
| fr | Intoxication par la colchicine | |
| de | Kolchizin-Vergiftung | |
| es | Intoxicación por colchicina | |
| it | Intossicazione da colchicina | |
| nl | Colchicinevergiftiging | |
| pt | Intoxicação por colquicina | |
| pl | Zatrucie kolchicyną | |
| cs | Otrava kolchicinem | |
| uk | Отруєння колхіцином | |
| zh | 秋水仙碱中毒 | |
| tr | Kolşisin zehirlenmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T50.4 | NTBT | index | validated |
| ICD-11 | NE60 | NTBT | index | validated |
| MONDO | 0017859 | E | validated | |
| UMLS | C0274779 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:306640Rare intoxication due to medical products
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | 0.1 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2011[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
29 annotations · validated 2017-01-26| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001944 | Dehydration | |
| HP:0002615 | Hypotension | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0001942 | Metabolic acidosis | |
| HP:0002018 | Nausea | |
| HP:0002098 | Respiratory distress | |
| HP:0002013 | Vomiting | |
| Frequent (79-30%) | ||
| HP:0003111 | Abnormal blood ion concentration | |
| HP:0004360 | Abnormality of acid-base homeostasis | |
| HP:0001871 | Abnormality of blood and blood-forming tissues | |
| HP:0006846 | Acute encephalopathy | |
| HP:0011675 | Arrhythmia | |
| HP:0030149 | Cardiogenic shock | |
| HP:0006543 | Cardiorespiratory arrest | |
| HP:0001635 | Congestive heart failure | |
| HP:0002014 | Diarrhea | |
| HP:0005521 | Disseminated intravascular coagulation | |
| HP:0002901 | Hypocalcemia | |
| HP:0002900 | Hypokalemia | |
| HP:0002917 | Hypomagnesemia | |
| HP:0002902 | Hyponatremia | |
| HP:0002148 | Hypophosphatemia | |
| HP:0011106 | Hypovolemia | |
| HP:0003128 | Lactic acidosis | |
| HP:0012819 | Myocarditis | |
| HP:0100520 | Oliguria | |
| HP:0004372 | Reduced consciousness | |
| HP:0000083 | Renal insufficiency | |
| Occasional (29-5%) | ||
| HP:0001596 | Alopecia | |
Run the differential on the 7 obligate / very frequent terms
Annotation source: 24196723[PMID]_24353429[PMID]_25257122[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/31824
- This record as JSON: /data/d/31824.json