{"orpha":31824,"name":"Colchicine poisoning","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Colchicine poisoning is a potentially life-threatening poisoning, due to ingestion of the drug or consumption of the plant <i>Colchicum autumnale</i>, that usually begins with gastrointestinal symptoms (e.g. abdominal pain, nausea, vomiting, and diarrhea, that cause severe dehydration) and an initial leukocytosis leading to marrow failure (24 hours after ingestion), followed by potentially fatal multi-organ failure with mental status change, oliguric renal failure, disseminated intravascular coagulation, electrolyte imbalance, acid-base disturbance, cardiac failure/arrest and shock within 1-3 days.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-31824/","orphanet_url":"https://www.orpha.net/en/disease/detail/31824","names":{"fr":{"name":"Intoxication par la colchicine","definition":"Intoxication potentiellement létale due à l'ingestion du médicament (colchicine) ou de la plante <i>Colchicum autumnale</i>, se manifestant généralement par des symptômes gastro-intestinaux (douleurs abdominales, nausées, vomissements et diarrhées, à l'origine d'une déshydratation sévère) et par une leucocytose initiale entraînant une insuffisance médullaire (24 heures après l'ingestion), suivis d'une défaillance potentiellement létale de plusieurs organes avec altération de l'état mental, insuffisance rénale oligurique, coagulation intravasculaire disséminée, déséquilibre électrolytique, déséquilibre acido-basique, insuffisance/arrêt cardiaque et choc en l'espace de 1 à 3 jours."},"de":{"name":"Kolchizin-Vergiftung","definition":"Die Vergiftung mit Colchicin ist eine potentiell lebensbedrohliche Vergiftung, die durch Einnahme des Arzneimittels oder durch den Verzehr der Pflanze <i>Colchicum autumnale</i> verursacht wird. Sie beginnt meist mit gastrointestinalen Symptomen (z.B. Bauchschmerzen, Übelkeit, Erbrechen und Durchfall) und kann eine schwere Dehydratation mit intialer Leukozytose verursachen. Die initiale Leukozytose kann zu einem Versagen der Knochenmarksfunktion (24 Stunden nach der Einnahme) und zu einem potenziell tödlichem Multiorganversagen mit mentaler Statusänderung, oligurischem Nierenversagen, disseminierter intravaskulärer Koagulation, Elektrolytverschiebung, Säure-Basen-Störung, Herzversagen/Herzstillstand und Schock innerhalb von 1-3 Tagen führen."},"es":{"name":"Intoxicación por colchicina","definition":"Es una intoxicación potencialmente letal debida a la ingesta del fármaco o consumo de la planta <i>Colchicum autumnale</i>, que por lo habitual comienza con síntomas gastrointestinales (p. ej. dolor abdominal, nausea, vómitos, y diarrea que provoca deshidratación grave) y una leucocitosis inicial que conduce a insuficiencia medular (24 horas después de la ingestión), seguida por un fallo multiorgánico con alteración del estado mental, insuficiencia renal oligúrica, coagulación intravascular diseminada, desequilibrio electrolítico, perturbaciones ácido-base, insuficiencia / paro cardíaco y shock en el periodo comprendido entre 1 y 3 días."},"it":{"name":"Intossicazione da colchicina","definition":"L'intossicazione da colchicina è un avvelenamento potenzialmente letale, causato dall'assunzione di un farmaco o dall'ingestione della pianta Colchicum autumnale. Di solito esordisce con sintomi gastrointestinali (dolore addominale, nausea, vomito e diarrea, che provocano una grave disidratazione), con leucocitosi iniziale che esita nell'insufficienza midollare (24 ore dopo l'ingestione), seguita dall'insufficienza multiorgano, potenzialmente letale, con alterazione dello stato mentale, insufficienza renale oligurica, coagulazione intravascolare disseminata, alterazioni elettrolitiche, alterazioni dell'equilibrio acido-base, insufficienza/arresto e shock cardiaco entro 1-3 giorni."},"nl":{"name":"Colchicinevergiftiging","definition":"Colchicinevergiftiging is een potentieel levensbedreigende vergiftiging als gevolg van inname van de drug of consumptie van de plant <i>Colchicum autumnale</i>. De ziekte begint meestal met gastro-intestinale symptomen (e.g. buikpijn, misselijkheid, braken, en diarree die ernstige dehydratie veroorzaakt) en een initiële leukocytose die leidt tot mergfalen (24 uur na ingestie), gevolgd door potentieel fataal multi-orgaanfalen met verandering van de mentale status, oligurisch nierfalen, verspreide intravasculaire coagulatie, verstoring van de elektrolytenbalans en het zuur-base-evenwicht, hartfalen/hartstilstand en shock binnen 1-3 dagen."},"pt":{"name":"Intoxicação por colquicina"},"pl":{"name":"Zatrucie kolchicyną"},"cs":{"name":"Otrava kolchicinem"},"uk":{"name":"Отруєння колхіцином","definition":"Colchicine poisoning is a potentially life-threatening poisoning, due to ingestion of the drug or consumption of the plant <i>Colchicum autumnale</i>, that usually begins with gastrointestinal symptoms (e.g. abdominal pain, nausea, vomiting, and diarrhea, that cause severe dehydration) and an initial leukocytosis leading to marrow failure (24 hours after ingestion), followed by potentially fatal multi-organ failure with mental status change, oliguric renal failure, disseminated intravascular coagulation, electrolyte imbalance, acid-base disturbance, cardiac failure/arrest and shock within 1-3 days."},"zh":{"name":"秋水仙碱中毒"},"tr":{"name":"Kolşisin zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T50.4","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"NE60","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1617857912"},{"source":"MONDO","code":"0017859","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0274779","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":306640,"name":"Rare intoxication due to medical products","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Europe","status":"Validated","source":"European Medicines Agency 2011[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-01-26","source":"24196723[PMID]_24353429[PMID]_25257122[PMID]","terms":[{"hpo":"HP:0001944","label":"Dehydration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001942","label":"Metabolic acidosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003111","label":"Abnormal blood ion concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004360","label":"Abnormality of acid-base homeostasis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001871","label":"Abnormality of blood and blood-forming tissues","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006846","label":"Acute encephalopathy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030149","label":"Cardiogenic shock","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006543","label":"Cardiorespiratory arrest","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001635","label":"Congestive heart failure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002901","label":"Hypocalcemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002900","label":"Hypokalemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002917","label":"Hypomagnesemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002902","label":"Hyponatremia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002148","label":"Hypophosphatemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011106","label":"Hypovolemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003128","label":"Lactic acidosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100520","label":"Oliguria","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001596","label":"Alopecia","frequency":"Occasional (29-5%)","criteria":null}]}}